[1]李正兰.重组人干扰素α1b治疗小儿手足口病的临床疗效观察[J].医学信息,2019,32(05):156-157.[doi:10.3969/j.issn.1006-1959.2019.05.050]
　LI Zheng-lan.Clinical Observation of Recombinant Human Interferon α1b in the Treatment of Hand-Foot-Mouth Disease in Children[J].Medical Information,2019,32(05):156-157.[doi:10.3969/j.issn.1006-1959.2019.05.050]
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重组人干扰素α1b治疗小儿手足口病的临床疗效观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年05期
页码:
156-157
栏目:
药物与临床
出版日期:
2019-03-01

文章信息/Info

Title:
Clinical Observation of Recombinant Human Interferon α1b in the Treatment of Hand-Foot-Mouth Disease in Children
文章编号:
1006-1959（2019）05-0156-02
作者:
李正兰
（苏州市立医院本部儿科，江苏 苏州 215002）
Author(s):
LI Zheng-lan
(Department of Pediatrics,Suzhou Municipal Hospital,Suzhou 215002,Jiangsu,China)
关键词:
重组人干扰素α1b; 手足口病; 皮疹
Keywords:
Recombinant human interferon α1b; Hand; foot and mouth disease; Rash
分类号:
R725.1
DOI:
10.3969/j.issn.1006-1959.2019.05.050
文献标志码:
A
摘要:
目的 观察重组人干扰素α1b治疗小儿手足口病的临床疗效。方法 选择我院2018年6月~8月儿科门诊收治的手足口病患儿60例，随机分为治疗组和对照组，各30例。对照组患儿给予一般抗病毒对症治疗，治疗组在此基础上加用重组人干扰素α1b注射液治疗。观察两组患儿治疗后热退时间、咽部充血程度改善时间、口腔溃疡愈合时间及皮疹消退时间，比较两组患儿的临床疗效。结果 治疗组总有效率为93.33%，高于对照组的70.00%，差异有统计学意义（P＜0.05）；治疗组的热退时间、咽峡部充血程度改善时间、口腔溃疡愈合时间及皮疹消退时间均短于对照组，差异有统计学意义（P＜0.05）。结论 重组人干扰素α1b注射液治疗小儿手足口病疗效确切，可有效加快患者临床症状改善，缩短患儿病程。
Abstract:
Objective To observe the clinical efficacy of recombinant human interferon α1b in the treatment of hand, foot and mouth disease in children.Methods 60 children with hand, foot and mouth disease admitted to our hospital from June to August 2018 were randomly divided into treatment group and control group, 30 cases each. The control group received general antiviral symptomatic treatment, and the treatment group was treated with recombinant human interferon α1b injection. The postoperative heat withdrawal time, the improvement time of pharyngeal congestion, the time of oral ulcer healing and the time of rash regression were observed in the two groups. The clinical effects of the two groups were compared. Results The total effective rate of the treatment group was 93.33%, which was higher than that of the control group 70.00%,the difference was statistically significant (P<0.05). The heat withdrawal time, the time of improvement of pharyngeal congestion, the healing time of oral ulcer and the rash subsided in the treatment group. The time was shorter than the control group,the difference was statistically significant (P<0.05).Conclusion Recombinant human interferon α1b injection is effective in the treatment of hand, foot and mouth disease in children, which can effectively improve the clinical symptoms of patients and shorten the course of children.

参考文献/References:


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更新日期/Last Update: 2019-03-01