[1]冯映栋,魏 波,孙永建,等.MicroRNA-26a对人骨髓间充质干细胞成骨分化机制在修复骨缺损研究进展[J].医学信息,2019,32(06):41-44.[doi:10.3969/j.issn.1006-1959.2019.06.015]
 FENG Ying-dong,WEI Bo,SUN Yong-jian,et al.Progress in the Mechanism of microRNA-26a on Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells in Repairing Bone Defects[J].Journal of Medical Information,2019,32(06):41-44.[doi:10.3969/j.issn.1006-1959.2019.06.015]
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MicroRNA-26a对人骨髓间充质干细胞成骨分化机制在修复骨缺损研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年06期
页码:
41-44
栏目:
综述
出版日期:
2019-03-15

文章信息/Info

Title:
Progress in the Mechanism of microRNA-26a on Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells in Repairing Bone Defects
文章编号:
1006-1959(2019)06-0041-04
作者:
冯映栋1魏 波1孙永建2王家丰1梁培杰1梁 振1
(1.广东医科大学附属医院骨科,广东 湛江 524000;2.南方医科大学第五附属医院骨科,广东 广州 510900)
Author(s):
FENG Ying-dong1WEI Bo1SUN Yong-jian2WANG Jia-feng1LIANG Pei-jie1LIANG Zhen1
(1.Department of Orthopaedics,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China;2.Department of Orthopaedics,the Fifth Affiliated Hospital of Southern Medical University, Guangzhou 510900,Guangdong,China)
关键词:
microRNA-26a人骨髓间充质干细胞成骨分化骨缺损
Keywords:
microRNA-26aHuman bone marrow mesenchymal stem cellsOsteogenic differentiationBone defect
分类号:
R683
DOI:
10.3969/j.issn.1006-1959.2019.06.015
文献标志码:
A
摘要:
人骨髓间充质干细胞是人体成骨分化的主要骨母干细胞来源,主导人的骨与软骨的再生与重建。近年在研究影响的影响因素上,microRNAs被报道其相关家族在骨髓间充质干细胞的分化过程中起着关键的调节控制作用,其中miRNA-26a在促进骨髓间充质干细胞成骨分化中起着关键作用。microRNA-26a通过影响Smad1、GSK3β、BMP、Id1信号通路增强骨髓间充质干细胞的成骨分化作用,从而促进骨质生成。本综述将阐述microRNAs家族作用于成骨分化的发现,进一步详细阐述microRNA-26a对人骨髓间充质干细胞的作用机制的研究发现和目前miRNA-26a转染骨髓间充质干细胞对修复骨缺损的研究进展。
Abstract:
Human bone marrow mesenchymal stem cells are the main source of osteoblasts for human osteogenic differentiation, leading to the regeneration and reconstruction of bone and cartilage.In recent years, influencing the influencing factors of microRNAs, microRNAs have been reported to play a key regulatory role in the differentiation of bone marrow mesenchymal stem cells. miRNA-26a plays an important role in promoting osteogenic differentiation of bone marrow mesenchymal stem cells.microRNA-26a enhances osteogenic differentiation of bone marrow mesenchymal stem cells by affecting Smad1, GSK3β, BMP, and Id1 signaling pathways.This review will describe the discovery of microRNAs family acting on osteogenic differentiation,the research on the mechanism of microRNA-26a on human bone marrow mesenchymal stem cells was further elaborated and the research progress of miRNA-26a transfected bone marrow mesenchymal stem cells on repairing bone defects.

参考文献/References:

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更新日期/Last Update: 2019-03-15