[1]孟琳非,黄伟健,酆孟洁,等.基于聚类分析对慢性肺部疾病表型的研究进展[J].医学信息,2019,(07):44-48.[doi:10.3969/j.issn.1006-1959.2019.07.015]
 MENG Lin-fei,HUANG Wei-jian,FENG Meng-jie,et al.Advances in Research on Phenotypes of Chronic Lung Diseases Based on Cluster Analysis[J].Medical Information,2019,(07):44-48.[doi:10.3969/j.issn.1006-1959.2019.07.015]
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基于聚类分析对慢性肺部疾病表型的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年07期
页码:
44-48
栏目:
综述
出版日期:
2019-04-01

文章信息/Info

Title:
Advances in Research on Phenotypes of Chronic Lung Diseases Based on Cluster Analysis
文章编号:
1006-1959(2019)07-0044-05
作者:
孟琳非黄伟健酆孟洁王凌伟邱 晨
(深圳市人民医院院/暨南大学第二临床医学院呼吸与重症医学科,广东 深圳 518000)
Author(s):
MENG Lin-feiHUANG Wei-jianFENG Meng-jieWANG Ling-weiQIU Chen
(Shenzhen People's Hospital/Department of Respiratory and Critical Care Medicine,the Second Clinical Medical College,Jinan University,Shenzhen 518000,Guangdong,China)
关键词:
聚类分析慢性肺部疾病表型研究慢性阻塞性肺病支气管哮喘支气管扩张间质性肺疾病曲霉菌病
Keywords:
Cluster analysisChronic lung diseasePhenotypic studyChronic obstructive pulmonary diseaseBronchial asthmaBronchiectasisInterstitial lung diseaseAspergillosis
分类号:
R563
DOI:
10.3969/j.issn.1006-1959.2019.07.015
文献标志码:
A
摘要:
慢性肺部疾病包括慢性阻塞性肺疾病(COPD)、支气管哮喘、支气管扩张、间质性肺病、肺结节病、尘病和慢性肺曲霉菌病等。这些疾病具有不同的临床表型,同一治疗方案对不同表型的疗效可能存在很大区别,因此准确分析表型对制定个体化治疗方案意义重大。聚类分析是依据研究对象距离远近与相似程度的差异,将它们分成不同亚型的统计学方法。近年来,学术界发现聚类分析可用于包括慢性肺部疾病在内多种疾病的表型研究。本文对慢性肺部疾病表型的聚类分析研究作一综述,总结出该类疾病表型研究的进展和聚类分析的常用研究策略。
Abstract:
Chronic lung diseases include chronic obstructive pulmonary disease (COPD), bronchial asthma, bronchiectasis, interstitial lung disease, pulmonary sarcoidosis, dust disease, and chronic pulmonary aspergillosis. These diseases have different clinical phenotypes, and the efficacy of the same treatment regimen for different phenotypes may vary greatly, so accurate analysis of the phenotype is of great significance for the development of individualized treatment options. Cluster analysis is based on the differences in distance and similarity of the subjects, and they are divided into statistical methods of different subtypes. In recent years, academic circles have found that cluster analysis can be used for phenotypic studies of a variety of diseases including chronic lung diseases. This article reviews the cluster analysis of chronic lung disease phenotypes, and summarizes the progress of phenotypic research and the commonly used research strategies for cluster analysis.

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更新日期/Last Update: 2019-04-01