[1]张媛媛,徐 曼.慢性乙型肝炎患者e抗原消失的临床特点[J].医学信息,2019,32(10):105-107.[doi:10.3969/j.issn.1006-1959.2019.10.033]
　ZHANG Yuan-yuan,XU Man.Clinical Features of e Antigen Disappearance in Patients with Chronic Hepatitis B[J].Journal of Medical Information,2019,32(10):105-107.[doi:10.3969/j.issn.1006-1959.2019.10.033]
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慢性乙型肝炎患者e抗原消失的临床特点()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年10期
页码:
105-107
栏目:
临床研究
出版日期:
2019-05-15

文章信息/Info

Title:
Clinical Features of e Antigen Disappearance in Patients with Chronic Hepatitis B
文章编号:
1006-1959（2019）10-0105-03
作者:
张媛媛; 徐 曼
（四川省中西医结合医院消化内科，四川 成都 610041）
Author(s):
ZHANG Yuan-yuan; XU Man
(Department of Gastroenterology,Sichuan Hospital of Integrated Traditional Chinese and Western Medicine,Chengdu 610041,Sichuan,China)
关键词:
慢性乙型肝炎; e抗原; 抗病毒治疗
Keywords:
Chronic hepatitis B; e antigen; Antiviral therapy
分类号:
R512.62
DOI:
10.3969/j.issn.1006-1959.2019.10.033
文献标志码:
A
摘要:
目的 探讨慢性乙型肝炎患者使用核苷类似物抗病毒治疗e抗原消失后HBV DNA、转氨酶等指标的变化特点。方法 选取2014年12月~2017年6月四川省中西医结合医院门诊109例慢性乙型肝炎患者，在服用核苷类似物抗病毒的治疗过程中出现e抗原消失，检测并分析治疗前后e抗原抗体系统的变化与HBV DNA关系、ALT异常率、血清HBV DNA水平与HBeAg相关性分析。结果 HBV DNA转小二阳时及转后半年、1年与治疗前比较，差异有统计学意义（P＜0.05）；转小二阳后半年与刚转小二阳时比较，差异有统计学意义（P＜0.05）；转小二阳后1年与刚转小二阳时比较，差异无统计学意义（P＞0.05）。治疗前和治疗后的ALT异常率比较，差异有统计学意义（P＜0.05），转小二阳时以及转后的半年、1年ALT异常率相比，差异均无统计学意义（P＞0.05）。血清HBV DNA水平与HBeAg呈正相关关系（r=0.879，P＜0.001）。结论 大三阳患者在治疗过程中，发生e抗原的消失的状态是不稳定的，仍然可能会出现病毒DNA的复制，转氨酶的异常。
Abstract:
Objective To investigate the changes of HBV DNA and transaminase in patients with chronic hepatitis B after anti-viral treatment with nucleoside analogue antiviral therapy. Methods A total of 109 patients with chronic hepatitis B from the outpatient department of Sichuan Provincial Hospital of Integrated Traditional Chinese and Western Medicine from December 2014 to June 2017 were selected. The e antigen disappeared during the antiviral treatment of nucleoside analogues. The e antigen was detected and analyzed before and after treatment. Changes in antibody system and HBV DNA, ALT abnormalities, serum HBV DNA levels and HBeAg correlation analysis.Results There was a significant difference between the two groups when HBV DNA was converted to primary two-positive, half a year after turning and one year before treatment (P<0.05), and there was a significant difference between the two groups in the second half-year after turning to primary two-positive (P<0.05), there was no significant difference between the two groups in the second a year after turning to primary two-positive (P＞0.05).There was a significant difference in the abnormal rate of ALT between before and after treatment (P<0.05). There was no significant difference in the abnormal rate of ALT at the time of conversion to primary two positive, half a year and one year after the treatment (P>0.05).There was a positive correlation between serum HBV DNA level and HBeAg(r=0.879, P<0.001). Conclusion In the treatment of Dasanyang patients, the state of disappearance of e antigen is unstable, and replication of viral DNA and abnormalities of transaminase may still occur.

参考文献/References:

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更新日期/Last Update: 2019-05-15