[1]于祥菊,宋碧莹,刘 滢,等.Chk1及其抑制剂调控肿瘤作用机制研究[J].医学信息,2019,(19):39.[doi:10.3969/j.issn.1006-1959.2019.19.013]
 YU Xiang-ju,SONG Bi-ying,LIU Ying,et al.Study on the Mechanism of Chk1 and Its Inhibitors Regulating Tumor[J].Medical Information,2019,(19):39.[doi:10.3969/j.issn.1006-1959.2019.19.013]





Study on the Mechanism of Chk1 and Its Inhibitors Regulating Tumor
于祥菊宋碧莹刘 滢吕冬霞
(佳木斯大学,黑龙江 佳木斯 154007)
YU Xiang-juSONG Bi-yingLIU YingLYU Dong-xia
(Jiamusi University,Jiamusi 154007,Heilongjiang,China)
Chk1InhibitorTumor cellsTumor suppressor gene
Cell cycle checkpoint kinase 1 (Chk1) is a serine/threonine (Ser/Thr kinase) encoded by the tumor suppressor gene Chk1 and is widely found in mammalian cells. In recent years, a number of domestic and foreign studies have shown that Chk1 and its inhibitors can regulate the formation and development of tumors. Based on this, based on the profile and application of Chk1 and its inhibitors, this paper summarizes the mechanism of multi-directional regulation of tumor cells, aiming to provide reference for the clinical application and development of Chk1 and its inhibitors, and the development of related drugs.


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更新日期/Last Update: 2019-10-01