ZHANG Xue-li.Correlation Between Serum 1,25(OH)2D3,MGO and Painful Neuropathy in Type 2 Diabetes[J].Medical Information,2019,(19):47-50.[doi:10.3969/j.issn.1006-1959.2019.19.015]





Correlation Between Serum 1,25(OH)2D3,MGO and Painful Neuropathy in Type 2 Diabetes
(赣州市人民医院老年病科,江西 赣州 341000)
ZHANG Xue-li
(Department of Geriatrics,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China)
Diabetic painful neuropathyMethylglyoxal125-dihydroxyvitamin D3
In recent years, diabetic painful neuropathy (PDN) has become a difficult problem for scholars in the field of endocrinology. Central sensitization and inflammatory response are important mechanisms for its pathogenesis. Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), can rapidly generate AGEs, which can be centrally sensitized by post-transcriptional modification of proteins, suggesting that MGO may be involved in the development of PDN.Vitamin D has anti-inflammatory and immunoregulatory functions,1,25(OH)2D3 is its active form. It has been shown that VitD3 can inhibit the expression of inflammatory cytokines in patients with type 2 diabetes, suggesting a good effect on preventing the development of type 2 diabetes and improving the complications of diabetes. But the specific mechanism is not clear. Whether MGO and 1,25(OH)2D3 may mediate the mechanism of diabetic painful neuropathy, there is a certain correlation between them, and there are few reports at home and abroad. Therefore, this study reviewed the relationship between MGO and 1,25(OH)2D3 and diabetic painful neuropathy and the relationship between the two.


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更新日期/Last Update: 2019-10-01