[1]李肖亮,陈 科,莫 非,等.脑干出血急性期氧化应激及炎性反应的相关性[J].医学信息,2019,32(20):60-62,66.[doi:10.3969/j.issn.1006-1959.2019.20.017]
　LI Xiao-liang,CHEN Ke,MO Fei,et al.Correlation between Oxidative Stress and Inflammatory Response in Acute Stage of Brain Stem Hemorrhage[J].Journal of Medical Information,2019,32(20):60-62,66.[doi:10.3969/j.issn.1006-1959.2019.20.017]
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脑干出血急性期氧化应激及炎性反应的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年20期
页码:
60-62,66
栏目:
论著
出版日期:
2019-10-15

文章信息/Info

Title:
Correlation between Oxidative Stress and Inflammatory Response in Acute Stage of Brain Stem Hemorrhage
文章编号:
1006-1959（2019）20-0060-04
作者:
李肖亮; 陈 科; 莫 非; 刘传明; 杨 鹏
（空军军医大学第一附属医院急诊科，陕西 西安 710032）
Author(s):
LI Xiao-liang; CHEN Ke; MO Fei; LIU Chuan-ming; YANG Peng
(Department of Emergency,the First Affiliated Hospital of Air Force Military Medical University, Xi'an 710032,Shaanxi,China)
关键词:
脑干出血; 炎性指标; 氧化应激; 急诊救治; 预后
Keywords:
Brain stem hemorrhage; Inflammatory index; Oxidative stress; Emergency treatment; Prognosis
分类号:
R743.34
DOI:
10.3969/j.issn.1006-1959.2019.20.017
文献标志码:
A
摘要:
目的 探讨脑干出血急性期氧化应激和炎性反应的相关性。方法 收集2015年10月~2018年10月我院收治的脑干出血患者46例，依照中国脑出血诊疗指导规范分为死亡组（25例）和生存组（21例）。比较两组天门冬氨酸转氨酶（AST）、丙氨酸氨基转移酶（ALT）、肌酐（CR）、尿素氮（BUN）、白细胞计数（WBC）、降钙素原（PCT）、白介素6（IL-6）、血乳酸、中性粒细胞计数、钠离子（Na）、钾离子（K）、钙离子（Ca）、乳酸脱氢酶（LDH）、肌酸激酶同工酶（CK-MB）、脑干出血量，分析脑干出血后氧化应激及炎性反应的相关性。结果 两组CR、BUN、PCT、Na、K、Ca、LDH、CK-MB、脑干出血量比较，差异无统计学意义（P＞0.05）；两组AST、ALT、WBC、中性粒细胞计数、IL-6比较，差异有统计学意义（P＜0.05）。Spearman相关性分析结果显示，WBC、中性粒细胞计数、血乳酸、IL-6、AST、ALT与脑干出血后氧化应激呈正相关（P＜0.05）。多元线性Logistic回归结果显示，WBC、中性粒细胞计数、血乳酸水平、IL-6是脑干出血后氧化应激的独立危险因素。结论 WBC、中性粒细胞计数、血乳酸水平、IL-6是脑干出血后氧化应激的独立危险因素，可用于脑干出血急诊的早期发现和干预，从而提高脑干出血急诊救治成功率，进一步降低死亡率和致残率。
Abstract:
Objective To investigate the correlation between oxidative stress and inflammatory response in the acute phase of brain stem hemorrhage. Methods 46 patients with brain stem hemorrhage admitted to our hospital from October 2015 to October 2018 were enrolled. According to the guidelines for diagnosis and treatment of cerebral hemorrhage in China, they were divided into death group (25 cases) and survival group (21 cases). Comparison of two groups of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (CR), urea nitrogen (BUN), white blood cell count (WBC), procalcitonin (PCT), interleukin 6 ( IL-6), blood lactate, neutrophil count, sodium ion (Na), potassium ion (K), calcium ion (Ca), lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB ), the amount of brain stem bleeding, analysis of the correlation between oxidative stress and inflammatory response after brain stem hemorrhage. Results There were no significant differences in CR, BUN, PCT, Na, K, Ca, LDH, CK-MB, and brain stem bleeding between the two groups (P>0.05). AST, ALT, WBC, and neutrophil counts in the two groups. Compared with IL-6, the difference was statistically significant (P<0.05). Spearman correlation analysis showed that WBC, neutrophil count, blood lactate, IL-6, AST, ALT were positively correlated with oxidative stress after brain stem hemorrhage (P<0.05). Multivariate linear logistic regression showed that WBC, neutrophil count, blood lactate level, and IL-6 were independent risk factors for oxidative stress after brain stem hemorrhage.Conclusion WBC, neutrophil count, blood lactate level and IL-6 are independent risk factors for oxidative stress after brain stem hemorrhage. They can be used for early detection and intervention of emergency treatment of brain stem hemorrhage, thus improving the success rate of emergency treatment of brain stem hemorrhage. To further reduce mortality and disability.

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更新日期/Last Update: 2019-10-15