[1]张 薇,王建梅.妊娠高血压患者NT-proBNP、sRAGE与心功能的关系[J].医学信息,2019,32(24):69-71.[doi:10.3969/j.issn.1006-1959.2019.24.022]
　ZHANG Wei,WANG Jian-mei.Relationship Between NT-proBNP,sRAGE and Cardiac Function in Patients with Pregnancy-induced Hypertension[J].Medical Information,2019,32(24):69-71.[doi:10.3969/j.issn.1006-1959.2019.24.022]
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妊娠高血压患者NT-proBNP、sRAGE与心功能的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年24期
页码:
69-71
栏目:
论著
出版日期:
2019-12-15

文章信息/Info

Title:
Relationship Between NT-proBNP,sRAGE and Cardiac Function in Patients with Pregnancy-induced Hypertension
文章编号:
1006-1959（2019）24-0069-03
作者:
张 薇1; 2; 王建梅1
（1.天津医科大学第二医院计划生育科，天津 300211；2.天津市滨海新区妇女儿童保健和计划生育服务中心，天津 300451）
Author(s):
ZHANG Wei1; 2; WANG Jian-mei1
(1.Department of Family Planning,The Second Hospital of Tianjin Medical University,Tianjin 300211,China;2.Tianjin Binhai New District Women and Children’s Health and Family Planning Service Center, Tianjin 300451,China)
关键词:
妊娠高血压; N末端脑钠肽前体; 可溶性晚期糖基化终末产物受体
Keywords:
Pregnancy hypertension; N-terminal brain natriuretic peptide precursor; Soluble advanced glycation end product receptor
分类号:
R714.246
DOI:
10.3969/j.issn.1006-1959.2019.24.022
文献标志码:
A
摘要:
目的 探讨妊娠高血压患者血清N末端脑钠肽前体（NT-proBNP）、可溶性晚期糖基化终末产物受体（sRAGE）的变化及其意义。方法 选取2015年4月~2019年8月我院确诊的妊娠高血压患者95例（病例组）及正常妊娠者95例（对照组），检测两组的血清NT-proBNP、sRAGE水平、左室舒张末期内径（LVDd）、左室射血分数（LVEF%）、心肌收缩峰值速度（Vs）、二尖瓣舒张早期运动速度/二尖瓣舒张晚期运动速度（E/A），分析血清NT-proBNP、sRAGE与LVEF及E/A的关系。结果 病例组血清NT-proBNP、sRAGE水平高于对照组，差异有统计学意义（P＜0.05）；病例组LVEF%、Vs、E/A低于对照组，差异有统计学意义（P＜0.05）；病例组的LVDd高于对照组，差异有统计学意义（P＜0.05）；妊娠高血压、轻度子痫前期、重度子痫前期孕妇血清NT-proBNP、sRAGE水平呈逐渐升高趋势，两两比较，差异均有统计学意义（P＜0.05）；妊娠高血压患者血清NT-proBNP、sRAGE水平与LVEF%、E/A值均呈负相关，差异均有统计学意义（P＜0.05）。结论 妊娠高血压患者血清NT-proBNP、sRAGE水平较正常妊娠妇女升高，并且与病情严重程度及发生心功能损害有关。
Abstract:
Objective To investigate the changes of serum N-terminal brain natriuretic peptide precursor (NT-proBNP) and soluble advanced glycation end product receptor (sRAGE) and their significance in pregnant hypertension. Methods A total of 95 patients with pregnancy-induced hypertension diagnosed in our hospital from April 2015 to August 2019 (case group) and 95 patients with normal pregnancy (control group) were selected. Serum NT-proBNP, sRAGE levels, and left ventricle were measured in both groups. End-diastolic diameter (LVDd), left ventricular ejection fraction (LVEF%), peak myocardial systolic velocity (Vs), early mitral valve diastolic motion rate / late mitral valve diastolic motion rate (E/A),The relationship between serum NT-proBNP and sRAGE and LVEF and E/A was analyzed. Results The serum NT-proBNP and sRAGE levels in the case group were higher than those in the control group,the differences were statistically significant (P<0.05). The LVEF%, Vs, and E/A in the case group were lower than those in the control group,the differences were statistically significant (P<0.05); The LVDd in the case group was higher than that in the control group,the difference was statistically significant (P<0.05); the serum levels of NT-proBNP and sRAGE in pregnant women with hypertension, mild preeclampsia and severe preeclampsia gradually increased,the difference was statistically significant (P<0.05); the levels of serum NT-proBNP and sRAGE in patients with pregnancy-induced hypertension were negatively correlated with LVEF% and E/A values,the differences were statistically significant (P<0.05). Conclusion Serum NT-proBNP and sRAGE levels in patients with pregnancy-induced hypertension are higher than those in normal pregnant women, and are related to the severity of the disease and the occurrence of cardiac function impairment.

参考文献/References:

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更新日期/Last Update: 2019-12-15