[1]李 倩,张 敏,汪镜静,等.早期集束化治疗在急性百草枯中毒患者中的应用[J].医学信息,2019,32(24):97-99.[doi:10.3969/j.issn.1006-1959.2019.24.032]
　LI Qian,ZHANG Min,WANG Jing-jing,et al.Application of Early Bundled Therapy in Patients with Acute Paraquat Poisoning[J].Medical Information,2019,32(24):97-99.[doi:10.3969/j.issn.1006-1959.2019.24.032]
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早期集束化治疗在急性百草枯中毒患者中的应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年24期
页码:
97-99
栏目:
临床研究
出版日期:
2019-12-15

文章信息/Info

Title:
Application of Early Bundled Therapy in Patients with Acute Paraquat Poisoning
文章编号:
1006-1959（2019）24-0097-03
作者:
李 倩; 张 敏; 汪镜静; 张 改; 徐 浩
（皖南医学院弋矶山医院急诊内科，安徽 芜湖 241001）
Author(s):
LI Qian; ZHANG Min; WANG Jing-jing; ZHANG Gai; XU Hao
(Department of Emergency Medicine,Yijishan Hospital,Wannan Medical College,Wuhu 241001,Anhui,China)
关键词:
百草枯中毒; 集束化治疗; 病死率
Keywords:
Paraquat poisoning; Cluster treatment; Mortality
分类号:
R595.4
DOI:
10.3969/j.issn.1006-1959.2019.24.032
文献标志码:
A
摘要:
目的 探讨早期集束化治疗在急性百草枯中毒患者预后中的应用价值。方法 选择2014年1月~2015年12月皖南医学院弋矶山医院确诊为急性百草枯中毒未实施集束化治疗的172例患者设为常规治疗组，以2016年1月~2017年12月入院实施集束化治疗的133例患者设为集束化治疗组，比较两组入院GCS评分、住院时间及各时间段病死率、生存率及不同时间点脏器功能指标变化。结果 两组入院GCS评分、住院时间、24 h病死率比较，差异无统计学意义（P＞0.05）；集束化治疗组48、72 h、2周病死率低于常规治疗组（36.84% vs 48.84%）、（40.60% vs 61.04%）、（42.11% vs 74.42%），差异有统计学意义（P＜0.05）。生存曲线分析结果显示，常规治疗组平均生存时间为[（18.52±1.86）d，95%CI：14.878~22.177]，低于集束化治疗组的[（40.01±2.01）d，95%CI：36.068~43.962]，差异有统计学意义（P＜0.05）。两组不同时间点PaO2、谷丙转氨酶、总胆红素、CK-MB、肌酐值比较，差异有统计学意义（P＜0.05）。结论 早期集束化治疗可以降低急性百草枯中毒患者入院48 h后病死率，改善脏器功能指标及生存预后，具有较高的临床应用价值。
Abstract:
Objective To explore the value of early bundled therapy in prognosis of patients with acute paraquat poisoning. Methods From January 2014 to December 2015, 172 patients diagnosed with acute paraquat poisoning in Yijishan Hospital, Wannan Medical College, who were not treated with cluster therapy were selected as the routine treatment group. They were admitted from January 2016 to December 2017. The 133 patients undergoing clustering treatment were set as the clustering treatment group. The admission GCS scores, length of stay, mortality, survival rate, and organ function indexes at different time points were compared between the two groups. Results There was no significant difference in GCS scores, length of hospitalization, and 24 h mortality in the two groups (P>0.05). The mortality rates at 48, 72 h, and 2 weeks in the cluster treatment group were lower than those in the conventional treatment group(36.84% vs 48.84%), (40.60% vs 61.04%), (42.11% vs 74.42%) ,the differences were statistically significant (P<0.05). Survival curve analysis showed that the average survival time of the conventional treatment group was [(18.52±1.86) d, 95%CI: 14.878~22.177], which was lower than that of the cluster treatment group [(40.01±2.01) d, 95%CI: 36.068~43.962], the difference was statistically significant (P<0.05). There were significant differences in PaO2, alanine aminotransferase, total bilirubin, CK-MB, and creatinine values between the two groups at different time points (P<0.05). Conclusion Early bundled therapy can reduce the mortality of patients with acute paraquat poisoning 48 h after admission, improve organ function indexes and survival prognosis.

参考文献/References:

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更新日期/Last Update: 2019-12-15