[1]王君君,张 莹.2014~2018年某三甲医院产生物膜铜绿假单胞菌耐药性及患者临床特征分析[J].医学信息,2020,33(02):129-131.[doi:10.3969/j.issn.1006-1959.2020.02.037]
　WANG Jun-jun,ZHANG Ying.Analysis of Drug Resistance of Pseudomonas Aeruginosa and Clinical Characteristics of Patients in a Top Three Hospital from 2014 to 2018[J].Medical Information,2020,33(02):129-131.[doi:10.3969/j.issn.1006-1959.2020.02.037]
点击复制

2014~2018年某三甲医院产生物膜铜绿假单胞菌耐药性及患者临床特征分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年02期
页码:
129-131
栏目:
调查分析
出版日期:
2020-01-15

文章信息/Info

Title:
Analysis of Drug Resistance of Pseudomonas Aeruginosa and Clinical Characteristics of Patients in a Top Three Hospital from 2014 to 2018
文章编号:
1006-1959（2020）02-0129-03
作者:
王君君1; 2; 张 莹1
（1.滨州医学院基础医学院，山东 烟台 264000；2.淄博市第一医院检验科，山东 淄博 255200）
Author(s):
WANG Jun-jun1; 2; ZHANG Ying1
(1.School of Basic Medicine,Binzhou Medical College,Yantai 264000,Shandong,China;2.Department of Laboratory Medicine,the First Hospital of Zibo City,Zibo 255200,Shandong,China)
关键词:
产生物膜铜绿假单胞菌; 耐药性; 临床特征
Keywords:
Pseudomonas aeruginosa producing drug resistance; Drug resistance; Clinical characteristics
分类号:
R378.99+1
DOI:
10.3969/j.issn.1006-1959.2020.02.037
文献标志码:
A
摘要:
目的 分析某三级甲等医院分离的产生物膜铜绿假单胞菌耐药性及患者的临床特征。方法 收集2014~2018年某三甲医院临床分离的产生物膜铜绿假单胞菌，进行菌种鉴定、抗菌药物敏感性试验并对药物的耐药率进行分析；收集患者的临床资料，并对感染患者临床特征进行分析。结果 2014~2018年临床分离的423株产生物膜铜绿假单胞菌均来自下呼吸道标本，来源以呼吸内科为主，年龄＞60岁、合并有支气管扩张等肺部基础疾病的患者易引起产生物膜铜绿假单胞菌的感染；2015~2018年产生物膜铜绿假单胞菌对亚胺培南、美罗培南的耐药率逐年下降。结论 产生物膜铜绿假单胞菌对碳青霉烯类抗生素及氨基糖苷类抗生素耐药率较低，低于非产生物膜的铜绿假单胞菌，临床微生物学实验室应选用可靠的药敏方法和合适的培养时间，为临床医生提供准确的药敏结果。
Abstract:
Objective To analyze the drug resistance of Pseudomonas aeruginosa produced in a tertiary hospital and its clinical characteristics. Methods The clinically isolated Pseudomonas aeruginosa produced in a top three hospital from 2014 to 2018 was collected for strain identification, antibacterial sensitivity test, and analysis of drug resistance rate. Collect clinical data of patients and analyze the clinical characteristics of infected patients.Results The 423 strains of Pseudomonas aeruginosa that were clinically isolated from 2014 to 2018 were derived from lower respiratory tract specimens. The source was mainly from respiratory medicine. Patients>60 years of age who had lung diseases such as bronchiectasis were prone to cause Infection of biofilm Pseudomonas aeruginosa; the drug-resistance rate of biofilm Pseudomonas aeruginosa to imipenem, and meropenem decreased from 2015 to 2018. Conclusion The biofilm-resistant Pseudomonas aeruginosa has a low resistance rate to carbapenem antibiotics and aminoglycoside antibiotics, which is lower than that of non-biofilm-producing Pseudomonas aeruginosa. Clinical microbiology laboratories should choose reliable drugs Sensitization methods and appropriate incubation times provide clinicians with accurate drug sensitivity results.

参考文献/References:

[1]Mulani MS,Kamble EE,Kumkar SN,et al.Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance:a review[J].Frontiers in Microbiology,2019,10(4):1-24. [2]尚红,王毓三,申子瑜.全国临床检验操作规程[M].第4版.北京:人民卫生出版社,2015:568-571. [3]Clinical And Laboratory Standards for antimicrobial susceptibility testing[M].Wayne:CLSI.2018:M100S. [4]James H.Jorgensen,Michael A.Pfaller.临床微生物学手册[M].王辉,马筱玲,钱渊,等,译.第11版.北京:中华医学电子音像出版社,2017:982-996. [5]Christiaen SEA,Matthijs N,Zhang XH,et al.Bacteria that inhibit quorum sensing decrease biofilm formation and virulence in Pseudomonas aeruginosa PAO1[J].FEMS Immunology&Medical Microbiology,2014,70(3):271-279. [6]牛瑜,姜天翼,庞力.阿奇霉素和克拉霉素对铜绿假单胞菌生物膜形成的作用[J].临床检验杂志,2018, 36(4):53-57. [7]Francesco I,Livia L,Paolo V.Antivirulence activity of azithromycin in Pseudomonas aeruginosa[J].Frontiers in Microbiology,2014,5(4):1-7. [8]高雅婷,李晓霞,段金菊.铜绿假单胞菌的群体感应系统及其抑制剂研究进展[J].中国抗生素杂志,2018,43(11):1338-1343.

相似文献/References:

[1]李淑惠.鲍曼不动杆菌临床分布及耐药性分析[J].医学信息,2018,31(03):165.[doi:10.3969/j.issn.1006-1959.2018.03.061]
　LI Shu-hui.Clinical Distribution and Drug Resistance of Acinetobacter Baumannii[J].Medical Information,2018,31(02):165.[doi:10.3969/j.issn.1006-1959.2018.03.061]
[2]张丽琴,刘 婷,刘 聪,等.赣南地区临床分离菌耐药性变迁及多重耐药菌的流行变化[J].医学信息,2018,31(05):123.[doi:10.3969/j.issn.1006-1959.2018.05.043]
　ZHANG Li-qin,LIU Ting,LIU Cong,et al.Changes of Drug Resistance of Clinical Isolates and Epidemic Changes of Multidrug-resistant Bacteria in Southern Guizhou[J].Medical Information,2018,31(02):123.[doi:10.3969/j.issn.1006-1959.2018.05.043]
[3]雷 敏.不孕不育患者解脲脲支原体培养及耐药性分析[J].医学信息,2018,31(06):156.[doi:10.3969/j.issn.1006-1959.2018.06.055]
　LEI Min.Analysis of Culture and Drug Resistance of Ureaplasma Urealyticum in Infertility Patients[J].Medical Information,2018,31(02):156.[doi:10.3969/j.issn.1006-1959.2018.06.055]
[4]曾 江,邹 燕,刘 滨.耐甲氧西林金黄色葡萄球菌的临床分布及耐药性分析[J].医学信息,2019,32(02):148.[doi:10.3969/j.issn.1006-1959.2019.02.043]
　ZENG Jiang,ZOU Yan,LIU Bin.Clinical Distribution and Drug Resistance Analysis of Methicillin-resistant Staphylococcus Aureus[J].Medical Information,2019,32(02):148.[doi:10.3969/j.issn.1006-1959.2019.02.043]
[5]高程凤,孙 蕊.新生儿败血症致病菌分布及耐药性分析[J].医学信息,2018,31(17):116.[doi:10.3969/j.issn.1006-1959.2018.17.035]
　GAO Cheng-feng,SUN Rui.Distribution and Drug Resistance of Pathogenic Bacteria in Neonatal Septicemia[J].Medical Information,2018,31(02):116.[doi:10.3969/j.issn.1006-1959.2018.17.035]
[6]张 美,王 欢,冯利芬.南京市江宁医院2015年~2017年血培养阳性病原菌分布及耐药性分析[J].医学信息,2018,31(20):108.[doi:10.3969/j.issn.1006-1959.2018.20.032]
　ZHANG Mei,WANG Huan,FENG Li-fen.Analysis of Distribution and Drug Resistance of Blood Culture Positive Pathogens in Jiangning Hospital of Nanjing from 2015 to 2017[J].Medical Information,2018,31(02):108.[doi:10.3969/j.issn.1006-1959.2018.20.032]
[7]彭 杰,张 琴.儿童呼吸内科下呼吸道分离菌分布及药敏分析[J].医学信息,2019,32(03):134.[doi:10.3969/j.issn.1006-1959.2019.03.043]
　PENG Jie,ZHANG Qin.Distribution and Drug Sensitivity Analysis of Lower Respiratory Tract Isolates inChildren's Respiratory Medicine[J].Medical Information,2019,32(02):134.[doi:10.3969/j.issn.1006-1959.2019.03.043]
[8]于文清.下呼吸道感染病原菌分布及耐药性分析[J].医学信息,2018,31(24):74.[doi:10.3969/j.issn.1006-1959.2018.24.019]
　YU Wen-qing.Analysis of Distribution and Drug Resistance of Pathogenic Bacteria in Lower Respiratory Tract Infection[J].Medical Information,2018,31(02):74.[doi:10.3969/j.issn.1006-1959.2018.24.019]
[9]李佳颖,李春霖,王玉莹,等.鲍曼不动杆菌的单药治疗及其联合使用的研究[J].医学信息,2019,32(05):48.[doi:10.3969/j.issn.1006-1959.2019.05.016]
　LI Jia-ying,LI Chun-lin,WANG Yu-ying,et al.Monotherapy of Acinetobacter Baumannii and Its Combined Use[J].Medical Information,2019,32(02):48.[doi:10.3969/j.issn.1006-1959.2019.05.016]
[10]何 静.上皮性卵巢癌化学治疗的研究[J].医学信息,2019,32(18):24.[doi:10.3969/j.issn.1006-1959.2019.18.009]
　HE Jing.Chemotherapy of Epithelial Ovarian Cancer[J].Medical Information,2019,32(02):24.[doi:10.3969/j.issn.1006-1959.2019.18.009]

更新日期/Last Update: 2020-01-15