[1]陈 琳.某院血流感染病原菌分布及耐药性分析[J].医学信息,2020,33(10):150-152.[doi:10.3969/j.issn.1006-1959.2020.10.044]
　CHEN Lin.Analysis of Distribution and Drug Resistance of Pathogens of Bloodstream Infection in a Hospital[J].Medical Information,2020,33(10):150-152.[doi:10.3969/j.issn.1006-1959.2020.10.044]
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某院血流感染病原菌分布及耐药性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年10期
页码:
150-152
栏目:
调查分析
出版日期:
2020-05-15

文章信息/Info

Title:
Analysis of Distribution and Drug Resistance of Pathogens of Bloodstream Infection in a Hospital
文章编号:
1006-1959（2020）10-0150-03
作者:
陈 琳
（天津市第二人民医院检验科，天津 300192）
Author(s):
CHEN Lin
(Department of Laboratory,Tianjin Second People’s Hospital,Tianjin 300192,China)
关键词:
血流感染; 血培养; 耐药率
Keywords:
Bloodstream infection; Blood culture; Drug resistance rate
分类号:
R446.5
DOI:
10.3969/j.issn.1006-1959.2020.10.044
文献标志码:
A
摘要:
目的 对血培养中病原菌的分布情况及其对主要抗菌药物的耐药性进行研究。方法 对2016年1月~2019年8月我院住院患者送检的7905例血培养标本，用BacT/ALERT 3D 血培养仪进行血培养，从培养结果阳性的培养瓶中分离出的菌株在VITEK-Compact Ⅱ微生物全自动分析仪中鉴定病原菌的种类，并进行药敏试验，从而对血培养阳性标本中病原菌的分布及耐药性进行分析。结果 血培养中共检出768株菌株，其中革兰氏阴性菌共421株（54.82%），革兰氏阳性菌共337株（43.88%），真菌10株（1.30%）。分离出的前5位菌株为：大肠埃希菌（152株）、肺炎克雷伯菌（96株）、人葡萄球菌人亚种（79株）、马耳他布鲁菌（64株）及表皮葡萄球菌（50株）。大肠埃希菌和肺炎克雷伯菌对氨苄西林的耐药率最高，分别为73.20%和97.06%；对头孢替坦、阿米卡星、美罗培南及亚胺培南较敏感。人葡萄球菌人亚、表皮葡萄球菌及金黄色葡萄球菌对苄青霉素的耐药率最高，分别为88.57%、93.94%及73.68%；对呋喃妥因、利奈唑胺和替加环素敏感性较高。结论 血培养中分离出的病原菌种类复杂，以革兰氏阴性菌居多，大肠埃希菌仍为主要致病菌。药敏结果显示病原菌耐药情况较严重，需加强对病原菌的监测工作，以指导临床合理使用抗菌药物。
Abstract:
Objective To study the distribution of pathogenic bacteria in blood culture and its resistance to major antibacterial drugs.Methods From January 2016 to August 2019, 7905 blood culture specimens from our hospital patients were examined by BacT / ALERT 3D blood culture instrument.The strains isolated from the culture bottles with positive culture results were used to identify the types of pathogenic bacteria in the VITEK-Compact Ⅱ microbial automatic analyzer, and to conduct drug sensitivity tests, so as to analyze the distribution and drug resistance of the pathogenic bacteria in blood culture positive specimen.Results A total of 768 strains were detected in blood culture, including 421 Gram-negative bacteria (54.82%), Gram-positive bacteria 337 (43.88%), and 10 fungi (1.30%). The top 5 isolates were: Escherichia coli (152 strains), Klebsiella pneumoniae (96 strains), Staphylococcus human subspecies (79 strains), Brucella malta (64 strains) and epidermis grapes Cocci (50 strains). The resistance rates of Escherichia coli and Klebsiella pneumoniae to ampicillin were the highest, 73.20% and 97.06% respectively; they were sensitive to cefotetan, amikacin, meropenem and imipenem. Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus aureus have the highest resistance rates to benzylpenicillin, 88.57%, 93.94% and 73.68% respectively;they are more sensitive to nitrofurantoin, linezolid and tigecycline.Conclusion The types of pathogenic bacteria isolated from blood culture are complex, and most are Gram-negative bacteria. Escherichia coli is still the main pathogenic bacteria. The results of drug susceptibility show that the resistance of pathogenic bacteria is serious, and it is necessary to strengthen the monitoring of pathogenic bacteria to guide the rational use of antibacterial drugs in clinic.

参考文献/References:

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更新日期/Last Update: 2020-05-15