[1]王新宙,任 曼,候彦州,等.新型冠状病毒肺炎的分子诊断技术及其防控措施[J].医学信息,2020,33(11):27-29,33.[doi:10.3969/j.issn.1006-1959.2020.11.010]
　WANG Xin-zhou,REN Man,HOU Yan-zhou,et al.Molecular Diagnosis Technology of Novel Coronavirus Pneumonia and Its Prevention and Control Measures[J].Medical Information,2020,33(11):27-29,33.[doi:10.3969/j.issn.1006-1959.2020.11.010]
点击复制

新型冠状病毒肺炎的分子诊断技术及其防控措施()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年11期
页码:
27-29,33
栏目:
综述
出版日期:
2020-06-01

文章信息/Info

Title:
Molecular Diagnosis Technology of Novel Coronavirus Pneumonia and Its Prevention and Control Measures
文章编号:
1006-1959（2020）11-0027-04
作者:
王新宙; 任 曼; 候彦州; 等
（1.西安医学院临床医学院陕西省呼吸病预防及诊治工程研究中心，陕西 西安 710021；2.西安医学院药学院，陕西 西安 710021）
Author(s):
WANG Xin-zhou; REN Man; HOU Yan-zhou; et al
(1.Shaanxi Provincial Respiratory Disease Prevention and Diagnosis and Treatment Engineering Research Center,Xi’an Medical College,Xi’an 710021,Shaanxi,China;2.School of Pharmacy,Xi’an Medical College,Xi’an 710021,Shaanxi,China)
关键词:
新型冠状病毒肺炎; 分子诊断; 防控措施
Keywords:
Novel coronavirus pneumonia; Molecular diagnosis; Prevention and control measures
分类号:
R563.1
DOI:
10.3969/j.issn.1006-1959.2020.11.010
文献标志码:
A
摘要:
新型冠状病毒肺炎（COVID-19）由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，是一种具有高度传染性的疾病。全球已有多个国家和地区暴发大规模COVID-19疫情，尤其是无症状感染者具传染性使得疫情防控更加的复杂和严峻。COVID-19尚无疫苗和特效药，尽早确诊并进行隔离和支持治疗是现阶段最有效的措施。目前COVID-19的病原学检测主要以核酸检测为主，同时结合临床表现、血清学免疫检测等可明确诊断。本文主要介绍分子诊断技术在COVID-19诊断中的应用，并梳理了目前的防控措施，旨在为疫情的防控提供参考。
Abstract:
The novel coronavirus pneumonia (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and is a highly contagious disease. There have been large-scale outbreaks of COVID-19 outbreaks in many countries and regions around the world, especially the asymptomatic infections are infectious, making the outbreak prevention and control more complicated and grim. COVID-19 has no vaccines and specific drugs, and early diagnosis and isolation and supportive treatment are the most effective measures at this stage. At present, the pathogenic detection of COVID-19 is mainly based on nucleic acid detection, and the diagnosis can be confirmed by combining clinical manifestations and serological immunoassay. This article mainly introduces the application of molecular diagnosis technology in the diagnosis of COVID-19, and combs the current prevention and control measures, aiming to provide reference for the prevention and control of epidemic situation.

参考文献/References:

[1]Chan JF,Yuan S,Kok KH,et al.A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission:a study of a family cluster[J].Lancet,2020,395(10223):514-523.[2]Huang QL,YuL P,Petros AM,et al.Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein[J].Biochemistry,2004,43(20):6059-6063.[3]中国新闻网.全球战疫：全球累计确诊人数超78万,意大利西班牙疫情现趋稳迹象[EB/OL].[2020-03-31].https://baijiahao.baidu.com/s?id=1662666582984605867&wfr=spider&for=pc.[4]World Health Organization.Clinical management of severe acute respiratory infection when Middle East respiratory syndrome coronavirus(MERS-CoV)infection is suspected:interimguidance[EB/OL].https://apps.who.int/iris/handle/10665/178529.[5]国家卫生健康委员会.新型冠状病毒感染的肺炎实验室检测技术指南(第二版)[EB/OL].[2020-02-24].http://www.nhc.gov.cn/xcs/yqfkdt/202001/c67cfe29ecf1470e8c7fc47d3b751e88.shtml.[6]国家卫生健康委员会.关于印发新型冠状病毒肺炎诊疗方案（试行第七版）的通知[EB/OL].[2020-03-03]. http://www.gov.cn/zhengce/zhengceku/2020-03/04/content_5486705.htm.[7]Zhang GP,Guo JQ,Wang XN.Immunochromatographic Lateral Flow Strip Tests[J].Methods in Molecular Biology,2009,504(169):169-183.[8]Briza PL,Arben M.Nanomaterials-Based (Bio)Sensing Systems for Safety and Security Applications[J].Portable Chemical Sensors,2012(5):43-61.[9]贾春平,赵建龙.免疫标记技术的进展及纳米技术在其中的应用[J].生命科学,2008(5):89-93.[10]国家卫生健康委办公厅.新型冠状病毒感染的肺炎诊疗方案(试行第五版)[EB/OL].[2020-02-05].http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml.[11]Roman W,Victor MC,Wolfgang G,et al.Virological assessment of hospitalized cases of coronavirus disease 2019[J].MedRxiv,2020.[12]Zou LR,Ruan F,Huang MX,et al.SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients[J].New England Journal of Medicine,2020,382(12):1177-1179.[13]国家卫生健康委办公厅.截至4月6日24时新型冠状病毒肺炎疫情最新情况[EB/OL].[2020-04-07].http://www.gov.cn/xinwen/2020-04/07/content_5499725.htm.[14]Mizumoto K,Kagaya K,Zarebski A,et al.Estimating the asymptomatic proportion of coronavirus disease 2019(COVID-19)cases on board the Diamond Princess cruise ship,Yokohama,Japan,2020[J].Eurosurveillance,2020,25(10):2000180.[15]Nishiura H,Kobayashi T,Suzuki A,et al.Estimation of the asymptomatic ratio of novel coronavirus infections(COVID-19)[J].International Journal of Infectious Diseases,2020.[16]Qiu J.Covert coronavirus infections could be seeding new outbreaks[J].Nature,2020.[17]中国疾病预防控制中心.新型冠状病毒肺炎公众防护指南(第二版)[M].北京:人民卫生出版社,2020.[18]Deng W,Bao LL,Gao H,et al.Rhesus macaques can be effectively infected with SARS-CoV-2 via ocular conjunctival route[J].BioRxiv,2020.[19]国家卫生健康委办公厅.关于印发新型冠状病毒肺炎防控方案（第六版）的通知[EB/OL].[2020-03-07].http://www.nhc.gov.cn/jkj/s3577/202003/4856d5b0458141fa9f376853224d41d7.shtml.[20]Ong SWX,Tan YK,Chiap Y,et al.Air,Surface Environmental,and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)From a Symptomatic Patient[J].JAMA,2020,323(16):1610-1612.[21]Zhou F,Yu T,Du R,et al.Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan,China:a retrospective cohort study[J].Lancet,2020,395(10229):1054-1062.[22]Bialek S,Boundy E,Bowen V,et al.Severe Outcomes Among Patients with Coronavirus Disease 2019(COVID-19)-United States,February 12-March 16,2020[J].MMWR.Morbidity and mortality weekly report,2020,69(12).[23]王端,鞠秀丽,谢峰,等.中国北方六省（自治区）儿童2019新型冠状病毒感染31例临床分析[J].中华儿科杂志,2020,58(4):269-274.

相似文献/References:

[1]魏谭伟.先天性无虹膜症PAX6致病基因分析及其分子诊断研究[J].医学信息,2022,35(10):78.[doi:10.3969/j.issn.1006-1959.2022.10.019]
　WEI Tan-wei.A PAX6 Pathogenic Gene Analysis and Molecular Diagnosis of Congenital Aniridia[J].Medical Information,2022,35(11):78.[doi:10.3969/j.issn.1006-1959.2022.10.019]
[2]严申龙,马 宁,任 杰,等.新型冠状病毒肺炎的CT影像特点及应用价值[J].医学信息,2020,33(04):1.[doi:10.3969/j.issn.1006-1959.2020.04.001]
　YAN Shen-long,MA Ning,REN Jie,et al.CT Imaging Characteristics and Application Value of Novel Coronavirus Pneumonia[J].Medical Information,2020,33(11):1.[doi:10.3969/j.issn.1006-1959.2020.04.001]
[3]邓灵波,周 雯,曾巧玲,等.疑似及确诊新冠肺炎的临床及胸部CT影像特点[J].医学信息,2020,33(04):4.[doi:10.3969/j.issn.1006-1959.2020.04.002]
　Deng Lingbo,Zhou Wen,Zeng Qiaoling,et al.Clinical and chest CT image analysis of the suspected and confirmed COVID-19 infected pneumonia[J].Medical Information,2020,33(11):4.[doi:10.3969/j.issn.1006-1959.2020.04.002]
[4]曹璐璐,李桂蓉,何 梅,等.新型冠状病毒肺炎疫情实习护生心理状况调查分析[J].医学信息,2020,33(09):114.[doi:10.3969/j.issn.1006-1959.2020.09.036]
　CAO Lu-lu,LI Gui-rong,HE Mei,et al.Investigation and Analysis of Psychological Status of Intern Nurses of Novel Coronavirus Pneumonia[J].Medical Information,2020,33(11):114.[doi:10.3969/j.issn.1006-1959.2020.09.036]
[5]王莉鸿,陈 慧,林 莉,等.绵阳市新型冠状病毒肺炎确诊病例流行病学特征分析[J].医学信息,2020,33(12):58.[doi:10.3969/j.issn.1006-1959.2020.12.018]
　WANG Li-hong,CHEN Hui,LIN Li,et al.Epidemiological Characteristics of Confirmed Cases of Novel Coronavirus Pneumonia in Mianyang[J].Medical Information,2020,33(11):58.[doi:10.3969/j.issn.1006-1959.2020.12.018]
[6]廖冬霞,邓 娇.新冠肺炎流行时期某高校护理专科生焦虑状况调查[J].医学信息,2020,33(12):120.[doi:10.3969/j.issn.1006-1959.2020.12.037]
　LIAO Dong-xia,DENG Jiao.Survey on Anxiety of Nursing College Students in a College during the Prevalence of Novel Coronary Pneumonia[J].Medical Information,2020,33(11):120.[doi:10.3969/j.issn.1006-1959.2020.12.037]
[7]王莉鸿,陈 慧,林 莉,等.移动CT诊疗车在新型冠状病毒肺炎防控中的应用[J].医学信息,2020,33(14):1.[doi:10.3969/j.issn.1006-1959.2020.14.001]
　WANG Li-hong,CHEN Hui,LIN Li,et al.Application of Mobile CT Diagnosis and Treatment Vehicle in Prevention and Control of COVID-19[J].Medical Information,2020,33(11):1.[doi:10.3969/j.issn.1006-1959.2020.14.001]
[8]叶廷巧,赵 亮,黎 东,等.新型冠状病毒肺炎疫情期间我院互联网线上问诊平台情况调查[J].医学信息,2020,33(13):142.[doi:10.3969/j.issn.1006-1959.2020.13.042]
　YE Ting-qiao,ZHAO Liang,LI Dong,et al.Investigation on the Internet Online Consultation Platform of our Hospital During the Outbreak of Novel Coronavirus Pneumonia[J].Medical Information,2020,33(11):142.[doi:10.3969/j.issn.1006-1959.2020.13.042]
[9]伍苑晨,何 梅,李希西,等.新型冠状病毒肺炎疫情期间医务人员负性情绪与社会支持调查与分析[J].医学信息,2020,33(14):119.[doi:10.3969/j.issn.1006-1959.2020.14.036]
　WU Yuan-chen,HE Mei,LI Xi-xi,et al.Investigation and Analysis of the Negative Emotions and Social Support of Medical Staff During the Outbreak of COVID-19[J].Medical Information,2020,33(11):119.[doi:10.3969/j.issn.1006-1959.2020.14.036]
[10]吴君华,李 惠,徐维国,等.COVID-19疫情背景下公众对医疗职业的认知及其子女学医意向的调查分析[J].医学信息,2020,33(14):125.[doi:10.3969/j.issn.1006-1959.2020.14.038]
　WU Jun-hua,LI Hui,XU Wei-guo,et al.Investigation and Analysis of the Public’s Cognition of Medical Professions and their Children’s Intention to Study Medicine under the Background of COVID-19 Epidemic[J].Medical Information,2020,33(11):125.[doi:10.3969/j.issn.1006-1959.2020.14.038]

更新日期/Last Update: 1900-01-01