[1]朱君涵,郭二鹏,张华旭,等.孤立性纤维性肿瘤的临床病理学特征分析[J].医学信息,2021,34(01):173-175.[doi:10.3969/j.issn.1006-1959.2021.01.048]
　ZHU Jun-han,GUO Er-peng,ZHANG Hua-xu,et al.Analysis of Clinicopathological Characteristics of Solitary Fibrous Tumor[J].Medical Information,2021,34(01):173-175.[doi:10.3969/j.issn.1006-1959.2021.01.048]
点击复制

孤立性纤维性肿瘤的临床病理学特征分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年01期
页码:
173-175
栏目:
诊疗技术
出版日期:
2021-01-01

文章信息/Info

Title:
Analysis of Clinicopathological Characteristics of Solitary Fibrous Tumor
文章编号:
1006-1959（2021）01-0173-03
作者:
朱君涵; 郭二鹏; 张华旭; 等
（解放军联勤保障部队第943医院病理科，甘肃 武威 733000）
Author(s):
ZHU Jun-han; GUO Er-peng; ZHANG Hua-xu; et al.
(Department of Pathology,the 943th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Wuwei 733000,Gansu,China)
关键词:
孤立性纤维性肿瘤; 临床病理学; 免疫组织化学
Keywords:
Solitary fibrous tumor; Clinicopathology:Immunohistochemistry
分类号:
R730.2
DOI:
10.3969/j.issn.1006-1959.2021.01.048
文献标志码:
A
摘要:
目的 探讨孤立性纤维性肿瘤（SFT）的临床病理学特征、诊断、鉴别诊断及预后。方法 回顾性分析解放军第943医院2014年1月~2019年12月收治的42例SFT患者的临床资料，分析其临床病理及免疫表型特征。结果 42例患者中男性20例，女性22例，年龄在24~69岁，中位年龄43岁；肿瘤直径1.0~23 cm，平均6.3 cm；发生于胸膜21例，胸膜外21例；38例为首发，4例为复发。镜下42例肿瘤组织均由梭形细胞组成，良性者（27例）肿瘤细胞多无固定结构生长，可呈条束、纹席状、血管外皮瘤样分布，细胞丰富区与稀疏区交替，细胞无明显异型性，核分裂少见；恶性者（15例）细胞排列紧密，有异型性，核分裂象易见。免疫组化。结果 Vimentin、CD34、CD99、Bcl-2为阳性；SMA、EMA、Desmin、S-100、CD117、DOG-1为阴性。恶性者Ki-67指数均＞10%。结论 孤立性纤维性肿瘤的组织形态多样，生物学行为不易预测，与其它软组织肿瘤鉴别较为困难，确诊主要依靠病理组织学及免疫组化结果。
Abstract:
Objective To investigate the clinicopathological characteristics, diagnosis, differential diagnosis and prognosis of solitary fibrous tumor (SFT).Methods Retrospectively analyze 42 cases of SFT diagnosed from January 2014 to December 2019 in the 943th Hospital of the People’s Liberation Army, analyze their clinicopathological and immunophenotypic characteristics.Results Among the 42 patients, 20 were males and 22 were females, aged 24 to 69 years, with a median age of 43 years; tumor diameter was 1.0 to 23 cm, with an average of 6.3 cm; 21 cases occurred in the pleura, 21 cases were extrapleural; 38 cases were the first 4 cases were recurrence. Under the microscope, 42 cases of tumor tissues were composed of spindle cells. In benign cases (27 cases), the tumor cells mostly grew without a fixed structure, and could be distributed in bundles, striated mats, and hemangiopericytomas. The cell-rich areas and sparse areas alternate. The cells had no obvious atypia, and mitoses were rare. Malignant patients (15 cases) have tightly arranged cells with atypia, and mitoses were easy to see. Immunohistochemical results: Vimentin, CD34, CD99, Bcl-2 were positive; SMA, EMA, Desmin, S-100, CD117, DOG-1 are negative. The Ki-67 index of malignant patients were all>10%.Conclusion Solitary fibrous tumors have diverse histological morphologies, and their biological behaviors are difficult to predict. It is difficult to differentiate from other soft tissue tumors. The diagnosis is mainly based on histopathological and immunohistochemical results.

参考文献/References:

[1]牛子民,郗彦凤.孤立性纤维性肿瘤中STAT6 CD34及ki67的表达与其良恶性的相关性研究[J].中国药学与临床,2018(7):1096-1099. [2]Stout AP,Murray MR.Hemangiopericytoma:A Vascular Tumor Featuring Zimmermann’s Pericytes[J].Ann Surg,1942,116(1):26. [3]阎晓玲.孤立性纤维性肿瘤/血管周细胞瘤[J].中国现代神经疾病杂志,2016(12):832. [4]曹钟,魏建国.孤立性纤维性肿瘤中GRIA2和STAT6的表达及意义[J].临床与实验病理学杂志,2019(11):1194-1199. [5]朱淑琴,李巍.孤立性纤维性肿瘤的临床病理研究[J].中外医疗,2019(4):35-37. [6]Tan MC,Brennan MF,Kuk D,et al.Histolog-based classification predicts pattern of recurrence and improves risk stratification in primary retroperitoneal sarcoma[J].Ann Surg,2016,263(3):593-600. [7]Kim JM,Choi YL,Kim YJ,et al.Comparison and evaluation of risk factors for meningeal,pleural and extrapleural solitary fibrous tumors:a clinic opathological study of 92 cases confirmed by STAT6 immunohistochemical staining[J].Pathol Res Pract,2017,213(6):619-625. [8]Gholami S,Cassidy MR,Kirane A,et al.Size and location are the most important risk factors for malignant behavior in resectedsolitary fibrous tumors[J].Ann Surg Oncol,2017,24(13):3865-3871. [9]Diebold M,Soltermann A,Hottinger S,et al.Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score-a multicenter study[J].Respir Res,2017,18(1):210.

更新日期/Last Update: 1900-01-01