[1]林 磊.血清同型半胱氨酸水平与中青年脑梗死后抑郁的相关性研究[J].医学信息,2021,34(02):127-128.[doi:10.3969/j.issn.1006-1959.2021.02.034]
　LIN Lei.Study on the Relationship Between Serum Homocysteine Level and Depression After Cerebral Infarction in the Young and Middle-aged[J].Medical Information,2021,34(02):127-128.[doi:10.3969/j.issn.1006-1959.2021.02.034]
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血清同型半胱氨酸水平与中青年脑梗死后抑郁的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年02期
页码:
127-128
栏目:
临床研究
出版日期:
2021-01-15

文章信息/Info

Title:
Study on the Relationship Between Serum Homocysteine Level and Depression After Cerebral Infarction in the Young and Middle-aged
文章编号:
1006-1959（2021）02-0127-02
作者:
林 磊
（新泰市人民医院神经内科，山东 新泰 271200）
Author(s):
LIN Lei
(Department of Neurology,Xintai People’s Hospital,Xintai 271200,Shandong,China)
关键词:
中青年; 脑梗死后抑郁; 同型半胱氨酸
Keywords:
Young and middle-aged; Depression after cerebral infarction; Homocysteine
分类号:
R749.1；R743.33
DOI:
10.3969/j.issn.1006-1959.2021.02.034
文献标志码:
A
摘要:
目的 探究中青年急性脑梗死后抑郁与血清同型半胱氨酸（Hcy）水平的关系。方法 收集我院2018年6月~2020年1月的100例脑梗死后抑郁患者设为脑梗死抑郁组，100例脑梗死后无抑郁患者设为脑梗死无抑郁组，另选同期中青年非脑梗死患者100例为对照组，比较三组间Hcy的水平。据HAMD-17得分将脑梗死后抑郁组患者分为轻度、中度及重度三个亚组，比较三组Hcy的水平。结果 脑梗死后抑郁组Hcy的水平高于脑梗死后无抑郁组、对照组（P＜0.05），且脑梗死后无抑郁组Hcy的水平高于对照组（P＜0.05）；重度抑郁患者Hcy水平高于中度、轻度抑郁患者（P＜0.05），且中度抑郁患者Hcy水平高于轻度抑郁患者（P＜0.05）；相关性分析结果显示HAMD得分与血清Hcy呈正相关性（r=0.458，P＜0.05）。结论 中青年急性脑梗死后抑郁的发生与血清Hcy水平相关，且Hcy水平越高，抑郁程度越重，早期监测Hcy水平并积极给予控制可能有助于有效降低梗死后抑郁的发生发展。
Abstract:
Objective To explore the relationship between depression and serum homocysteine(Hcy) levels after acute cerebral infarction in young people.Methods A total of 100 patients with depression after cerebral infarction in our hospital from June 2018 to January 2020 were selected as the cerebral infarction depression group, and 100 patients without depression after cerebral infarction were selected as the cerebral infarction non-depression group. 100 patients with cerebral infarction served as the control group, and the Hcy levels between the three groups were compared. According to the HAMD-17 score, patients in the post-infarction depression group were divided into three subgroups: mild, moderate and severe, and the levels of Hcy in the three groups were compared.Results The Hcy level of the depression group after cerebral infarction was higher than that of the non-depression group and the control group after cerebral infarction(P＜0.05), and the Hcy level of the non-depression group after cerebral infarction was higher than that of the control group (P＜0.05);The Hcy level of severely depressed patients was higher than that of moderate and mildly depressed patients (P＜0.05), and the Hcy level of moderately depressed patients was higher than that of mildly depressed patients (P＜0.05);The results of correlation analysis showed that the HAMD score was positively correlated with serum Hcy (r=0.458,P＜0.05).Conclusion The occurrence of depression after acute cerebral infarction in the young and middle-aged is related to the serum Hcy level, and the higher the Hcy level, the more severe the depression. Early monitoring of Hcy level and active control may help to effectively reduce the occurrence and development of post-infarction depression.

参考文献/References:

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更新日期/Last Update: 1900-01-01