[1]贾敏鑫,李东霞.皮肤恶性肿瘤转移机制的研究[J].医学信息,2021,34(08):36-40.[doi:10.3969/j.issn.1006-1959.2021.08.010]
 JIA Min-xin,LI Dong-xia.Study on the Mechanism of Skin Malignant Tumor Metastasis[J].Medical Information,2021,34(08):36-40.[doi:10.3969/j.issn.1006-1959.2021.08.010]
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皮肤恶性肿瘤转移机制的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年08期
页码:
36-40
栏目:
综述
出版日期:
2021-04-15

文章信息/Info

Title:
Study on the Mechanism of Skin Malignant Tumor Metastasis
文章编号:
1006-1959(2021)08-0036-05
作者:
贾敏鑫李东霞
(内蒙古医科大学附属医院皮肤科,内蒙古 呼和浩特 010050)
Author(s):
JIA Min-xinLI Dong-xia
(Department of Dermatology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China)
关键词:
皮肤恶性肿瘤分子生物学肿瘤微环境
Keywords:
Skin malignant tumorMolecular biologyTumor microenvironment
分类号:
R751.05
DOI:
10.3969/j.issn.1006-1959.2021.08.010
文献标志码:
A
摘要:
皮肤恶性肿瘤是人类肿瘤中最常见的一种,全球范围内其发病率正在逐年上升,而导致患者发生死亡的主要原因是肿瘤的侵袭和转移。肿瘤转移是多因素、多阶段的,其过程复杂。目前临床上对皮肤恶性肿瘤转移机制的研究尚有很多未知领域。本文从不同角度对皮肤恶性肿瘤转移机制相关的分子生物学、非编码RNA、EMT及肿瘤微环境等方面进行了综述,随着研究的不断深入,期待在肿瘤转移机制中寻找肿瘤治疗的新的靶点,为提高皮肤恶性肿瘤患者生存率和生活质量提供新的契机。
Abstract:
Skin malignant tumors are the most common type of human tumors, and their incidence is increasing year by year worldwide. The main cause of death of patients is tumor invasion and metastasis.Tumor metastasis is multi-factor and multi-stage, and its process is complicated. At present, there are still many unknown areas in clinical research on the metastasis mechanism of skin malignant tumors.This article reviews the molecular biology, non-coding RNA, EMT, and tumor microenvironment related to skin malignant tumor metastasis from different perspectives. With the deepening of research, we look forward to finding new tumor treatments in tumor metastasis mechanisms. The target provides a new opportunity for improving the survival rate and quality of life of patients with skin malignant tumors.

参考文献/References:

[1]Darr OA,Colacino JA,Tang AL,et al.Epigenetic alterations in metastatic cutaneous carcinoma[J].Head Neck,2015,37(7):994-1001. [2]CSCO黑色素瘤专家委员会.中国黑色素瘤诊治指南(2015版)[M].北京:人民卫生出版社,2015:17-18. [3]樊静媛,李娟,王素林,等.p53、Bcl-2和Ki-67表达与综合方法治疗皮肤基底细胞癌疗效的相关性分析[J].临床合理用药杂志,2016(10):135-136. [4]Pellegrini C,Maturo MG,Di Nardo L,et al.Understanding the Molecular Genetics of Basal Cell Carcinoma[J].Int J Mol Sci,2017,18(11):2485. [5]South AP,Purdie KJ,Watt SA,et al.NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis[J].J Invest Dermatol,2014,134(10):2630-2638. [6]Li YY,Hanna GJ,Laga AC,et al.(2015)Genomic analysis of metastatic cutaneous squamous cell carcinoma[J].Clin Cancer Res,2015,21(6):1447-1456. [7]Hervás-Marín D,Higgins F,Sanmartín O,et al.Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma[J].PLoS One,2019,14(12):e0223341. [8]Marzese DM,Scolyer RA,Roque M,et al.DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations[J].Neuro Oncol,2014,16(11):1499-1509. [9]Marzese DM,Liu M,Huynh JL,et al.Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome[J].Pigment Cell Melanoma Research,2014,28(1):82-93. [10]Liu L,Wang Y,Bai R,et al.MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1alpha regulation[J].Oncogenesis,2017(6):e318. [11]Yao K,He L,Gan Y,et al.MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1[J].Diagn Pathol,2015(10):146. [12]Zhang TJ,Wang YX,Yang DQ,et al.Down-Regulation of miR-186 Correlates with Poor Survival in de novo Acute Myeloid Leukemia[J].Clin Lab,2016(62):113-120. [13]宋昊.miR-128靶向CCL18调控黑素瘤细胞侵袭转移机制分析[D].北京协和医学院,2017. [14]Goswami S,Tarapore RS,Poenitzsch Strong AM,et al.MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor(MITF)mRNA is inhibited by coding region determinant-binding protein(CRD-BP)[J].J Biol Chem,2015,290(1):384-395. [15]Varrone F,Caputo E.The miRNAs Role in Melanoma and in Its Resistance to Therapy[J].Int J Mol Sci,2020,21(3):878. [16]Olasz EB,Seline LN,Schock AM,et al.MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma[J].PLoS One,2015,10(5):e0125412. [17]Chen B,Pan W,Lin X,et al.MicroRNA-346 functions as an oncogene in cutaneous squamous cell carcinoma[J].Tumour Biol,2016,37(2):2765-2771. [18]Sand M,Hessam S,Amur S,et al.Expression of oncogenic miR-17-92 and tumor suppressive miR-143-145 clusters in basal cell carcinoma and cutaneous squamous cell carcinoma[J].J Dermatol Sci,2017,86(2):142-148. [19]Mizrahi A,Barzilai A,Gur-Wahnon D,et al.Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma:the role of miR-497 in epithelial to mesenchymal transition of keratinocytes[J].Oncogene,2018,37(2):218-230. [20]Toll A,Salgado R,Espinet B,et al.MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression[J].Mol Cancer,2016,15(1):53. [21]Cantile M,Scognamiglio G,Marra L,et al.HOTAIR role in melanoma progression and its identification in the blood of patients with advanced disease[J].J Cell Physiol,2017,232(12):3422-3432. [22]Li R,Zhang L,Jia L,et al.Long non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation[J].PLoS One,2015,10(3):e0118728. [23]Tian Y,Zhang X,Hao Y,et al.Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma[J].Melanoma Res,2014,24(4):335-341. [24]Yu GJ,Sun Y,Zhang DW,et al.Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma[J].Cancer Cell Int,2019(19):270. [25]Mei XL,Zhong S.Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFR[J].Chin Med J(Engl),2019,132(4):454-465. [26]Piipponen M,Heino J,Kahari VM,et al.Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression[J].Biol Open,2018,7(11):bio037044. [27]Yin WB,Yan MG,Fang X,et al.Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection[J].Clin Chim Acta,2018(487):363-368. [28]Chen Z,Kang K,Chen S,et al.Circular RNA circ_0017247 promotes melanoma migration and invasion via targeting miR-145[J].Eur Rev Med Pharmacol Sci,2020,24(4):1932-1938. [29]Sand M,Bechara FG,Gambichler T,et al.Circular RNA expression in cutaneous squamous cell carcinoma[J].J Dermatol Sci,2016,83(3):210-218. [30]Sand M,Bechara FG,Sand D,et al.Circular RNA expression in basal cell carcinoma[J].Epigenomics,2016,8(5):619-632. [31]Peppicelli S,Bianchini F,Torre E,et al.Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells[J].Clin Exp Metastasis,2014,31(4):423-433. [32]Chen Y,Lu X,Montoya-Durango DE,et al.ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression[J].Sci Rep,2017,7(1):45. [33]Kosnopfel C,Sinnberg T,Sauer B,et al.YB-1 Expression and Phosphorylation Regulate Tumorigenicity and Invasiveness in Melanoma by Influencing EMT[J].Mol Cancer Res,2018,16(7):1149-1160. [34]Li B,Shen W,Peng H,et al.Fibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT[J].Onco Targets Ther,2019(12):3207-3221. [35]Zhang J,Jiang H,Xu D,et al.DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-β1/Smad Signaling Pathway[J].Onco Targets Ther,2019(12):9395-9405. [36]Chen H,Pan J,Zhang L,et al.Downregulation of estrogen-related receptor alpha inhibits human cutaneous squamous cell carcinoma cell proliferation and migration by regulating EMT via fibronectin and STAT3 signaling pathways[J].Eur J Pharmacol,2018(825):133-142. [37]刘亦晴.皮肤鳞状细胞癌和基底细胞癌中HIF-1α、PCNA、VEGF的表达与微血管密度的关系[D].郑州大学,2007. [38]Sasaki K,Sugai T,Ishida K,et al.Analysis of cancer-associated fibroblasts and the epithelial-mesenchymal transition in cutaneous basal cell carcinoma, squamous cell carcinoma,and malignant melanoma[J].Hum Pathol,2018(79):1-8. [39]Plzák J,Boucek J,Bandúrová V,et al.The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy[J].Cancers(Basel),2019,11(4):440. [40]Gurzu S,Beleaua MA,Jung I.The role of tumor microenvironment in development and progression of malignant melanomas-a systematic review[J].Rom J Morphol Embryol,2018,59(1):23-28. [41]杜娜雯,白日兰,崔久嵬.肿瘤免疫逃逸机制及治疗策略[J].中国肿瘤生物治疗杂志,2019,26(4):454-462. [42]Tampa M,Mitran MI,Mitran CI,et al.Mediators of Inflammation-A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma[J].J Immunol Res,2018(2018):1061780. [43]Soumoy L,Kindt N,Ghanem G,et al.Role of macrophage migration inhibitory factor(MIF)in melanoma[J].Cancers,2019,11(4):529. [44]Santana AL,Felsen D,Carucci JA.Interleukin-22 and Cyclosporine in Aggressive Cutaneous Squamous Cell Carcinoma[J].Dermatol Clin,2017,35(1):73-84. [45]Surcel M,Constantin C,Caruntu C,et al.Inflammatory cytokine pattern is sex-dependent in mouse cutaneous melanoma experimental model[J].J Immunol Res,2017(2017):9212134.

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更新日期/Last Update: 1900-01-01