[1]曹水仙,张 莉,罗文利,等.PLR与不稳定心绞痛患者冠脉病变严重程度的相关性[J].医学信息,2021,34(14):101-105.[doi:10.3969/j.issn.1006-1959.2021.14.027]
　CAO Shui-xian,ZHANG Li,LUO Wen-li,et al.Correlation Between PLR and the Severity of Coronary Artery Disease in Patients with Unstable Angina Pectoris[J].Medical Information,2021,34(14):101-105.[doi:10.3969/j.issn.1006-1959.2021.14.027]
点击复制

PLR与不稳定心绞痛患者冠脉病变严重程度的相关性()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年14期
页码:
101-105
栏目:
论著
出版日期:
2021-07-15

文章信息/Info

Title:
Correlation Between PLR and the Severity of Coronary Artery Disease in Patients with Unstable Angina Pectoris
文章编号:
1006-1959（2021）14-0101-05
作者:
曹水仙; 张 莉; 罗文利; 等
（石河子大学医学院第一附属医院心血管内科，新疆 石河子 832000）
Author(s):
CAO Shui-xian; ZHANG Li; LUO Wen-li; et al.
(Department of Cardiovascular Medicine,the First Affiliated Hospital of School of Medicine, Shihezi University,Shihezi 832000,Xinjiang,China)
关键词:
冠状动脉病变; 不稳定心绞痛; 血小板/淋巴细胞比值
Keywords:
Coronary artery disease; Unstable angina pectoris; Platelet/lymphocyte ratio
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2021.14.027
文献标志码:
A
摘要:
目的 研究PLR与不稳定心绞痛患者冠脉病变严重程度的相关性。方法 回顾性分析2018年1月~2019年12月于石河子大学第一附属医院明确诊断为不稳定心绞痛（UA）230例，根据SYNTAX评分分为冠状动脉轻度病变组（SYNTAX评分＜23分）137例和冠状动脉中重度病变组（SYNTAX评分≥23分）93例，比较两组一般资料及实验室检查结果，通过二元Logistic回归分析UA患者冠状动脉严重程度的危险因素，采用Spearman相关性分析LDL-C/HDL-C、PLR与冠状动脉SYNTAX评分的关系，绘制受试者工作特征（ROC）曲线分析不同指标对UA患者冠状动脉严重程度的诊断价值。结果 ①两组年龄、性别、高血压病史、糖尿病病史、吸烟史比较，差异均无统计学意义（P＞0.05）；两组ApoA1、ApoB、TC、HDL、LDL、ApoB/ApoA1、TC/HDL-C、LDL-C/HDL-C、PLR比较，差异均有统计学意义（P＜0.05）；②单因素及多因素Logistic回归分析显示，LDL-C/HDL-C、PLR是UA患者冠状动脉病变严重程度的独立危险因素；③Spearman相关性分析显示，LDL-C/HDL-C、PLR与UA患者SYNTAX评分呈正相关（r=0.397、0.373，P＜0.05)；④LDL-C/HDL-C、PLR诊断冠状动脉病变严重程度的ROC曲线下面积分别为0.733、0.719，两项指标联合诊断冠状动脉病变严重程度的ROC曲线下面积为0.785。结论 LDL-C/HDL-C、PLR与UA患者冠状动脉病变严重程度密切相关，可作为判断UA患者冠状动脉病变严重程度的独立危险因素，两者联合使用对冠状动脉病变严重程度的预测准确度较高。
Abstract:
Objective To study the correlation between PLR and the severity of coronary artery disease in patients with unstable angina pectoris.Methods A retrospective analysis of 230 cases of unstable angina (UA) diagnosed in the First Affiliated Hospital of Shihezi University from January 2018 to December 2019.According to the SYNTAX score, they were divided into a mild coronary artery disease group (SYNTAX score<23 points) 137 cases and a moderate to severe coronary artery disease group (SYNTAX score≥23 points) 93 cases.Compare the general information and laboratory test results between the two groups,binary Logistic regression was used to analyze the risk factors of coronary artery severity in UA patients, and Spearman correlation was used to analyze the relationship between LDL-C/HDL-C, PLR and coronary SYNTAX score.Draw receiver operating characteristic (ROC) curves to analyze the diagnostic value of different indicators for coronary artery severity in UA patients.Results ① There was no significant difference in age, gender, history of hypertension, history of diabetes, and smoking history between the two groups (P>0.05);Comparing the two groups of ApoA1, ApoB, TC, HDL, LDL, ApoB/ApoA1, TC/HDL-C, LDL-C/HDL-C, PLR, the differences were statistically significant (P<0.05);②Single factor and multivariate Logistic regression analysis showed that LDL-C/HDL-C and PLR are independent risk factors for the severity of coronary artery disease in UA patients;③Spearman correlation analysis showed that LDL-C/HDL-C, PLR and UA patients’ SYNTAX score were positively correlated (r=0.397, 0.373, P＜0.05);④The area under the ROC curve for LDL-C/HDL-C and PLR to diagnose the severity of coronary artery disease was 0.733 and 0.719, respectively, and the area under the ROC curve for the combined diagnosis of the severity of coronary artery disease by the two indicators was 0.785.Conclusion LDL-C/HDL-C and PLR are closely related to the severity of coronary artery disease in UA patients, and can be used as independent risk factors for judging the severity of coronary artery disease in UA patients.The combination of the two has a higher accuracy in predicting the severity of coronary artery disease.

参考文献/References:

[1]中国心血管病报告编写组.《中国心血管病报告2018》概要[J].中国循环杂志,2019,34(3):209-220. [2]邵中兴,顾宁.蒲参胶囊联合阿托伐他汀对冠心病合并血脂异常病人血脂水平的影响[J].中西医结合心脑血管病杂志,2016,14(3):282-284. [3]Balta S,Demirkol S,Kucuk U.The platelet lymphocyte ratio may be useful inflammatory indicator in clinical practice[J].Hemodial Int,2013,66(17):8-12. [4]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.非ST段抬高型急性冠状动脉综合征诊断和治疗指南(2016)[J].中华心血管病杂志,2017,45(5):359-376. [5]Chistiakov DA,Orekhov AN,Bobryshev YV.Endothelial PECAM-1 and its function in vascular physiology and atherogenic pathology[J].Exp Mol Pathol,2016,100(3):409-415. [6]Chistiakov DA,Orekhov AN,Bobryshev YV,et al.ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease[J].Lab Invest,2016,96(7):708-718. [7]Wang Y,Wang W,Wang N,et al.Mitochondrial oxidative stress promotes atherosclerosis and neutrophil extracellular traps in aged mice[J].Arterioscler Thromb Vasc Biol,2017,37(8):99-107. [8]Magro M,Nauta S,Simsek C,et al.Value of the SYNTAX score in patients treated by primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: The MI SYNTAXscore study[J].Am Heart J,2011,161(4):771-781. [9]Weng Q,Deng K,Wu F,et al.Leukocyte telomere length, lipid parameters and gestational diabetes risk: a case-control study in a Chinese population[J].Sci Rep,2019,9(1):8483. [10]Kunutsor SK,Zaccardi F,Karppi J,et al.Is high serum LDL/HDL cholesterol ratio an emerging risk factor for cholesterol ratio an emerging risk factor for sudden cardiac death Findings from the KIHD study[J].J Atheroscler Thromb,2017,24(6):600-608. [11]潘广杰.心绞痛患者LDL/HDL、中性粒细胞/淋巴细胞比值与其冠状动脉病变程度的关系[J]. 齐齐哈尔医学院学报,2017(13):1527-1529. [12]Diem S,Schmid S,Krapf M,et a1.Neutrophil-to-lymphocyte ratio (NLR)and platelet-to-lymphocyte ratio(PLR)as prognostic markers in patients with non-small cell lung cancer(NSCLC) treated with nivolumab[J].Lung Cancer,2017(111):176-181. [13]Ma XM,Sun X,Yang GW,et a1.The platelet—to-lymphocyte ratio as apredictor of patient outcomes in ovarian cancer：a meta-analysis[J].Climacteric,2017,20(5):448. [14]Akboga MK,Canpolat U,Yayla C,et al.Association of Platelet to Lymphocyte Ratio With Inflammation and Severity of Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease[J].Angiology,2016,67(1):89-95. [15]马岳,魏鳌,胡越成,等.血小板一淋巴细胞比值与冠状动脉病变复杂性的相关分析[J].天津医科大学学报,2019,25(6):595-598.

相似文献/References:

[1]宫慧超,王 辉,刘迎午.尼可地尔联合曲美他嗪在不稳定心绞痛患者中应用的临床研究[J].医学信息,2019,32(07):148.[doi:10.3969/j.issn.1006-1959.2019.07.045]
　GONG Hui-chao,WANG Hui,LIU Ying-wu.Clinical Study of Nicorandil Combined with Trimetazidine in Patients with Unstable Angina Pectoris[J].Medical Information,2019,32(14):148.[doi:10.3969/j.issn.1006-1959.2019.07.045]
[2]倪 明.吸烟对女性冠心病患者冠状动脉粥样硬化的影响[J].医学信息,2019,32(15):54.[doi:10.3969/j.issn.1006-1959.2019.15.018]
　NI Ming.Effect of Smoking on Coronary Atherosclerotic Disease in Female Patients with Coronary Heart Disease[J].Medical Information,2019,32(14):54.[doi:10.3969/j.issn.1006-1959.2019.15.018]
[3]李雪兰,余永雄.Apo-A1/Apo-B、视黄醇结合蛋白与绝经后女性冠心病患者冠状动脉病变程度的关系[J].医学信息,2021,34(11):181.[doi:10.3969/j.issn.1006-1959.2021.11.052]
　LI Xue-lan,YU Yong-xiong.The Relationship Between Apo-A1/Apo-B,Retinol Binding Protein and the Degree of Coronary Artery Disease in Postmenopausal Women with Coronary Heart Disease[J].Medical Information,2021,34(14):181.[doi:10.3969/j.issn.1006-1959.2021.11.052]
[4]刘 圆.血清γ-谷氨酰基转移酶水平对预测冠心病患者冠状动脉病变程度的价值[J].医学信息,2022,35(19):96.[doi:10.3969/j.issn.1006-1959.2022.19.026]
　LIU Yuan.Value of Serum γ-glutamyltransferase Level in Predicting the Severity of Coronary Artery Disease in Patients with Coronary Heart Disease[J].Medical Information,2022,35(14):96.[doi:10.3969/j.issn.1006-1959.2022.19.026]
[5]郭东梅,张文华,周锦云.不典型川崎病患儿Th17细胞因子水平与冠状动脉病变的关系[J].医学信息,2022,35(22):92.[doi:10.3969/j.issn.1006-1959.2022.22.018]
　GUO Dong-mei,ZHANG Wen-hua,ZHOU Jin-yun.The Relationship Between Th17 Cytokine Levels and Coronary Artery Lesions in Children with Atypical Kawasaki Disease[J].Medical Information,2022,35(14):92.[doi:10.3969/j.issn.1006-1959.2022.22.018]

更新日期/Last Update: 1900-01-01