[1]符 榕,赵 彦,杨 斌,等.学龄期1型糖尿病患儿发生酮症酸中毒的影响因素研究[J].医学信息,2021,34(16):115-117,124.[doi:10.3969/j.issn.1006-1959.2021.16.031]
　FU Rong,ZHAO Yan,YANG Bin,et al.Study on the Influencing Factors of Ketoacidosis in School-age Children with Type 1 Diabetes[J].Medical Information,2021,34(16):115-117,124.[doi:10.3969/j.issn.1006-1959.2021.16.031]
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学龄期1型糖尿病患儿发生酮症酸中毒的影响因素研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年16期
页码:
115-117,124
栏目:
论著
出版日期:
2021-08-15

文章信息/Info

Title:
Study on the Influencing Factors of Ketoacidosis in School-age Children with Type 1 Diabetes
文章编号:
1006-1959（2021）16-0115-04
作者:
符 榕; 赵 彦; 杨 斌; 等
（天津市儿童医院/天津大学儿童医院内分泌科，天津 300000）
Author(s):
FU Rong; ZHAO Yan; YANG Bin; et al.
(Tianjin Children’s Hospital/Department of Endocrinology,Children’s Hospital of Tianjin University,Tianjin 300000,China)
关键词:
1型糖尿病; 学龄期; 糖尿病酮症酸中毒; 体重指数; C肽
Keywords:
Type 1 diabetes; School-age; Diabetic ketoacidosis; Body mass index; C peptide
分类号:
R72
DOI:
10.3969/j.issn.1006-1959.2021.16.031
文献标志码:
A
摘要:
目的 探索影响学龄期1型糖尿病患儿发生糖尿病酮症酸中毒的危险因素，以期降低此类患儿酮症酸中毒的发生率。方法 选择2019年1月~2020年10月我院收治的52例学龄期1型糖尿病儿童作为未发生组，另外选择同期我院收治的45例学龄期1型糖尿病合并酮症酸中毒儿童作为发生组，自制基线资料调查量表，收集两组基线资料，采用Logistic回归分析影响学龄期1型糖尿病患儿发生酮症酸中毒的危险因素。结果 两组年龄、性别、家族史比较，差异无统计学意义（P＞0.05）；发生组前驱感染、延误诊断发生率高于未发生组，C肽、BMI水平低于未发生组，差异有统计学意义（P＜0.05）；Logistic回归分析显示，学龄期1型糖尿病儿童合并前驱感染、延误诊断、C肽水平较低、BMI较低是导致其发生酮症酸中毒的危险因素（OR=10.651、2.648、4.985、15.284，P＜0.05）。结论 前驱感染、延误诊断、C肽及BMI水平均与1型糖尿病酮症酸中毒密切相关，应制定针对性干预措施，以降低酮症酸中毒的发生风险。
Abstract:
Objective To explore the risk factors of diabetic ketoacidosis in school-age children with type 1 diabetes, in order to reduce the incidence of ketoacidosis in such children.Methods 52 school-age type 1 diabetes children admitted to our hospital from January 2019 to October 2020 were selected as the non-occurring group.In addition, 45 school-age children with type 1 diabetes and ketoacidosis admitted to our hospital during the same period were selected as the occurrence group, and the baseline data survey scale was self-made, and the baseline data of the two groups were collected.Logistic regression analysis was used to analyze the risk factors of ketoacidosis in school-age children with type 1 diabetes.Results There was no statistically significant difference between the two groups in age, gender, and family history (P>0.05);The incidence of pre-infection and delayed diagnosis in the occurrence group was higher than that of the non-occurring group, and the levels of C peptide and BMI were lower than those of the non-occurring group, the difference was statistically significant (P<0.05);Logistic regression analysis showed that pre-infection, delayed diagnosis, low C-peptide levels, and low BMI were risk factors for ketoacidosis in school-age children with type 1 diabetes (OR=10.651, 2.648, 4.985, 15.284, P<0.05).Conclusion Pre-infection, delayed diagnosis, C-peptide and BMI levels are closely related to type 1 diabetic ketoacidosis, and targeted intervention measures should be developed to reduce the risk of ketoacidosis.

参考文献/References:

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更新日期/Last Update: 1900-01-01