[1]郝绍文,虎 林,肖红科,等.可溶性白细胞分化抗原14亚型联合qSOFA评分对脓毒症的早期诊断价值[J].医学信息,2021,34(18):170-172.[doi:10.3969/j.issn.1006-1959.2021.18.047]
　HAO Shao-wen,HU Lin,XIAO Hong-ke,et al.The Value of Soluble Leukocyte Differentiation Antigen 14 SubtypeCombined with qSOFA Score in the Early Diagnosis of Sepsis[J].Medical Information,2021,34(18):170-172.[doi:10.3969/j.issn.1006-1959.2021.18.047]
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可溶性白细胞分化抗原14亚型联合qSOFA评分对脓毒症的早期诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年18期
页码:
170-172
栏目:
诊疗技术
出版日期:
2021-09-18

文章信息/Info

Title:
The Value of Soluble Leukocyte Differentiation Antigen 14 SubtypeCombined with qSOFA Score in the Early Diagnosis of Sepsis
文章编号:
1006-1959（2021）18-0170-03
作者:
郝绍文; 虎 林; 肖红科; 周生虎; 杨立山; 陈中伟; 康向飞
宁夏医科大学总医院急诊科，宁夏 银川 750000
Author(s):
HAO Shao-wen; HU Lin; XIAO Hong-ke; ZHOU Sheng-hu; YANG Li-shan; CHEN Zhong-wei; KANG Xiang-fei
Emergency Department,General Hospital of Ningxia Medical University,Yinchuan 750000,Ningxia,China
关键词:
可溶性白细胞分化抗原14亚型; qSOFA评分; 脓毒症; 降钙素原; C-反应蛋白
Keywords:
Soluble leukocyte differentiation antigen 14 subtype; qSOFA score; Sepsis; Procalcitonin; C-reactive protein
分类号:
R459.7
DOI:
10.3969/j.issn.1006-1959.2021.18.047
文献标志码:
A
摘要:
目的 探讨可溶性白细胞分化抗原14亚型（Presepsin）联合qSOFA评分在脓毒症患者早期诊断中的临床意义。方法 选取2019年7月-2020年8月我科救治的121例系统性炎症反应综合征（SIRS）患者，根据脓毒症的诊断标准分为脓毒症组84例和非感染性SIRS组37例，比较两组Presepsin、C-反应蛋白（CRP）、降钙素原（PCT）表达情况及qSOFA评分；绘制ROC曲线，比较Presepsin联合qSOFA评分对脓毒症的早期诊断价值。结果 脓毒症组Presepsin、CRP、PCT和qSOFA评分高于非感染性SIRS组，差异有统计学意义（P＜0.05）；ROC曲线显示，Presepsin预测脓毒症的ROC曲线下面积（AUC）为0.977（95%CI：0.956~0.998），敏感度为94.02%，特异度为89.19%；qSOFA评分预测脓毒症的ROC曲线AUC为0.859（95%CI：0.782~0.936），敏感度为90.50%，特异度为72.97%；Presepsin联合qSOFA评分检测预测脓毒症的ROC曲线AUC为0.988（95%CI：0.974~0.999），敏感度为90.50%，特异度为99.21%。结论 Presepsin联合qSOFA评分可用于脓毒症的早期诊断，两者联合应用具有良好的预测价值。
Abstract:
Objective To investigate the clinical significance of soluble leukocyte differentiation antigen 14 subtype (Presepsin) combined with qSOFA score in the early diagnosis of sepsis.Methods A total of 121 patients with systemic inflammatory response syndrome (SIRS) treated in our department from July 2019 to August 2020 were selected.According to the diagnostic criteria of sepsis, they were divided into 84 cases in sepsis group and 37 cases in non-infectious SIRS group. The expressions of Presepsin, C-reactive protein (CRP), procalcitonin (PCT) and qSOFA score were compared between the two groups;Drawing ROC curve and compare the value of Presepsin combined with qSOFA score in the early diagnosis of sepsis.Results The scores of Presepsin, CRP, PCT and qSOFA in the sepsis group were higher than those in the non-infectious SIRS group,the difference was statistically significant(P<0.05);The ROC curve showed that the area under the ROC curve (AUC) of Presepsin predicting sepsis was 0.977 (95%CI: 0.956-0.998), the sensitivity was 94.02%, and the specificity was 89.19%;The ROC curve AUC of qSOFA score predicting sepsis was 0.859 (95%CI: 0.782-0.936), the sensitivity was 90.50%, and the specificity was 72.97%;Presepsin combined with qSOFA score detection predicts sepsis ROC curve AUC was 0.988 (95%CI: 0.974-0.999), sensitivity was 90.50%, specificity was 99.21%.Conclusion Presepsin combined with qSOFA score can be used for the early diagnosis of sepsis, and the combination of the two has good predictive value.

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更新日期/Last Update: 1900-01-01