[1]王 静,陈亚东,张建平.门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的疗效[J].医学信息,2021,34(19):155-157.[doi:10.3969/j.issn.1006-1959.2021.19.042]
　WANG Jing,CHEN Ya-dong,ZHANG Jian-ping.Efficacy of Insulin Aspart and Insulin Detemir in the Treatment of Gestational Diabetes Mellitus[J].Medical Information,2021,34(19):155-157.[doi:10.3969/j.issn.1006-1959.2021.19.042]
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门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年19期
页码:
155-157
栏目:
药物与临床
出版日期:
2021-10-01

文章信息/Info

Title:
Efficacy of Insulin Aspart and Insulin Detemir in the Treatment of Gestational Diabetes Mellitus
文章编号:
1006-1959（2021）19-0155-03
作者:
王 静1; 陈亚东1; 张建平2
1.射阳县人民医院内分泌科，江苏 射阳 224300；2.西安工会医院药剂科，陕西 西安 710100
Author(s):
WANG Jing1; CHEN Ya-dong1; ZHANG Jian-ping2
1.Department of Endocrinology,Sheyang County People’s Hospital,Sheyang 224300,Jiangsu,China;2.Department of Pharmacy,Xi’an Trade Union Hospital,Xi’an 710100,Shaanxi,China
关键词:
妊娠糖尿病; 地特胰岛素; 门冬胰岛素; 胰岛素抵抗; 分娩结局
Keywords:
Gestational diabetes mellitus; Insulin detemir; Insulin aspart; Insulin resistance; Delivery outcome
分类号:
R714.256
DOI:
10.3969/j.issn.1006-1959.2021.19.042
文献标志码:
A
摘要:
目的 观察门冬胰岛素联合地特胰岛素治疗妊娠糖尿病（GDM）的疗效。方法 选取2018年10月-2020年10月射阳县人民医院收治的GDM孕妇80例作为研究对象，采用随机数字表法分为对照组和联合组，各40例。对照组给予门冬胰岛素治疗，联合组在对照组基础上联合地特胰岛素治疗，比较两组血糖水平、血糖恢复正常时间、胰岛素抵抗情况、脂肪因子及分娩结局。结果 联合组用药后14 d FPG、HOMA-IR、LEP、ADP、RBP4、HbA1c水平低于对照组，HOMA-β水平高于对照组，差异有统计学意义（P＜0.05）；两组2hPG、FINS水平比较，差异无统计学意义（P＞0.05）。联合组FPG、2hPG及双指标恢复正常时间短于对照组，差异有统计学意义（P＜0.05）；两组不良分娩结局发生率比较，差异无统计学意义（P＞0.05）。结论 门冬胰岛素联合地特胰岛素治疗GDM效果确切，可改善患者血糖水平，降低胰岛素抵抗作用，优化分娩结局。
Abstract:
Objective To observe the effect of insulin aspart and insulin detemir in treatment of gestational diabetes mellitus.Methods A total of 80 cases of GDM pregnant women who were treated in Sheyang County People’s Hospital from October 2018 to October 2020 were selected as research objects, randomly divided into control group and combination group,with 40 cases in each group. The control group was treated with insulin aspart, the combination group was treated with insulin detemir on the basis of the control group. The blood glucose level, blood glucose return to normal time, insulin resistance, fat factor and delivery outcome were compared between the two groups.Results After 14 d of medication, the levels of FPG, HOMA-IR, LEP, ADP, RBP4 and HbA1c in combination group were lower than those in control group, the level of HOMA-β was higher than that in control group, and the difference was statistically significant (P<0.05); while there was no statistically significant difference in 2hPG and FINS between the two groups(P>0.05). The level of FPG, 2hPG and two indexes were all restored to normal time in combination group were shorter than those in control group, and the difference was statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse delivery outcomes between the two groups(P>0.05).Conclusion The combined application of insulin aspart and insulin detemir for pregnant women with GDM has an ideal effect, which can improve blood sugar control, reduce insulin resistance, optimize adipokines levels, and improve delivery outcomes.

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更新日期/Last Update: 1900-01-01