[1]侯青青,杨 越,徐景超.骨水泥与骨形态发生蛋白对骨生长的影响[J].医学信息,2021,34(21):84-87.[doi:10.3969/j.issn.1006-1959.2021.21.021]
　HOU Qing-qing,YANG Yue,XU Jing-chao.Effect of Bone Cement and Bone Morphogenetic Protein on Bone Growth[J].Medical Information,2021,34(21):84-87.[doi:10.3969/j.issn.1006-1959.2021.21.021]
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骨水泥与骨形态发生蛋白对骨生长的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年21期
页码:
84-87
栏目:
论著
出版日期:
2021-11-01

文章信息/Info

Title:
Effect of Bone Cement and Bone Morphogenetic Protein on Bone Growth
文章编号:
1006-1959（2021）21-0084-04
作者:
侯青青; 杨 越; 徐景超
（河南理工大学医学院1，骨科研究所2，河南 焦作 454000）
Author(s):
HOU Qing-qing; YANG Yue; XU Jing-chao
(School of Medicine1,Institute of Orthopedics2,Henan Polytechnic University,Jiaozuo 454000,Henan,China)
关键词:
骨水泥; 骨组织切片; 骨形态发生蛋白
Keywords:
Bone cement; Bone tissue sections; Bone morphogenetic protein
分类号:
R687.4
DOI:
10.3969/j.issn.1006-1959.2021.21.021
文献标志码:
A
摘要:
目的 研究骨水泥与骨形态发生蛋白对骨生长的影响。方法 制作骨水泥，选择新西兰家兔20只并随机分为4组，每组5只，分别在兔子左右股骨处进行填充，将左侧植入骨水泥复合骨形态发生蛋白材料设为实验组，右侧植入单纯羟基磷灰石骨水泥材料设为空白组。6周后拍摄X光片，分析两组骨水泥填充结果及骨组织切片结果。结果 兔子伤口愈合情况良好，体重较稳定，无异物无免疫排斥反应及其他感染现象发生。术后6周拍片结果显示，实验组骨缺损间隙模糊，材料体积变小，降解非常明显，新骨形成多，并且骨连接紧密；空白组部位有空隙存在，材料变化不明显。实验组新骨共计生成10个界限生成7个空白组新骨形成7个界限生成5个。骨切片结果显示，实验组染色较浅，另外有较多的新骨组织生成，降解明显；而空白组染色较深，新生骨形成较少，且降解不明显。结论 复合材料骨水泥对周围骨组织有促进生长的作用，且对周围骨组织无不良影响，无排斥反应。
Abstract:
Objective To study the effect of bone cement and bone morphogenetic protein on bone growth.Methods Twenty New Zealand rabbits were randomly divided into four groups, with five in each group. The rabbits were filled in the left and right femurs, respectively. The left implanted bone cement composite bone morphogenetic protein material was set as the experimental group, and the right implanted hydroxyapatite bone cement material was set as the blank group. After 6 weeks, X-ray films were taken to analyze the results of bone cement filling and bone tissue sections in the two groups.Results Rabbit wound healing was good, weight was stable, no foreign body immune rejection and other infection. Six weeks after operation, the film results showed that the bone defect gap in the experimental group was fuzzy, the material volume was smaller, the degradation was very obvious, the new bone formation was more, and the bone connection was tight. There were gaps in the blank group, and the material changes were not obvious. In the experimental group, a total of 10 new bones were generated, and 7 boundaries were generated. The blank group formed 7 new bones and 5 boundaries. The results of bone sections showed that the staining in the experimental group was shallow, and there were more new bone tissues generated and degraded significantly, while the blank group had deeper staining, less new bone formation and no obvious degradation.Conclusion Composite bone cement can promote the growth of surrounding bone tissue, and has no adverse effect on surrounding bone tissue and no rejection reaction.

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更新日期/Last Update: 1900-01-01