[1]黄晓聪,王秋香,邱锦华.不同剂量甘露醇治疗高血压性脑出血患者降颅压效果的临床研究[J].医学信息,2021,34(22):124-126.[doi:10.3969/j.issn.1006-1959.2021.22.038]
　HUANG Xiao-cong,WANG Qiu-xiang,QIU Jin-hua.Clinical Study on the Effect of Different Doses of Mannitol in the Treatment of Hypertensive Cerebral Hemorrhage[J].Medical Information,2021,34(22):124-126.[doi:10.3969/j.issn.1006-1959.2021.22.038]
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不同剂量甘露醇治疗高血压性脑出血患者降颅压效果的临床研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年22期
页码:
124-126
栏目:
药物与临床
出版日期:
2021-11-15

文章信息/Info

Title:
Clinical Study on the Effect of Different Doses of Mannitol in the Treatment of Hypertensive Cerebral Hemorrhage
文章编号:
1006-1959（2021）22-0124-03
作者:
黄晓聪; 王秋香; 邱锦华
（信丰县人民医院神经内科二区，江西 信丰 341600）
Author(s):
HUANG Xiao-cong; WANG Qiu-xiang; QIU Jin-hua
(The Second Department of Neurology,Xinfeng County People’s Hospital,Xinfeng 341600,Jiangxi,China)
关键词:
甘露醇; 高血压性脑出血; 神经功能
Keywords:
Mannitol; Hypertensive cerebral hemorrhage; Nerve function
分类号:
R743.34
DOI:
10.3969/j.issn.1006-1959.2021.22.038
文献标志码:
A
摘要:
目的 研究不同剂量甘露醇治疗高血压性脑出血患者降颅压临床效果。方法 选取2020年3月-2021年8月我院治疗的90例高血压性脑出血患者为研究对象，采用随机数字表法分为A组、B组、C组，各30例。A组采用甘油氯化钠及神经细胞营养药物对症治疗，B组、C组在A组基础上分别采用20%甘露醇250 ml、125 ml静脉输注治疗。比较三组临床治疗效果、出血量、血肿体积、神经功能缺损（NIHSS）评分、日常生活能力（ADL）分级情况以及临床不良反应发生情况。结果 B组、C组治疗总有效率高于A组（P＜0.05）；而C组与B组治疗总有效率比较，差异无统计学意义（P＞0.05）。B组、C组出血量小于A组（P＜0.05），而C组与B组出血量比较，差异无统计学意义（P＞0.05）；B组、C组血肿体积小于A组，且C组小于B组（P＜0.05）。B组、C组NIHSS评分低于A组（P＜0.05），而C组与B组NIHSS评分比较，差异无统计学意义（P＞0.05）。C组、B组ADLⅠ~Ⅲ级占比高于A组，Ⅳ~Ⅴ级占比低于A组，且C组Ⅰ~Ⅲ级占比高于B组，Ⅳ~Ⅴ级占比低于B组（P＜0.05）。在治疗和观察期间，C组不良反应发生率低于B组、A组（P＜0.05）。结论 不同剂量甘露醇治疗高血压性脑出血均可获得相同的降颅压效果，但是与250 ml甘露醇比较，125 ml甘露醇可有效提高患者日常生活能力分级，减小血肿，降低不良反应发生率。
Abstract:
Objective To study the clinical effect of different doses of mannitol in the treatment of hypertensive cerebral hemorrhage.Methods A total of 90 patients with hypertensive cerebral hemorrhage treated in our hospital from March 2020 to August 2021 were selected as the research subjects. They were divided into group A, group B and group C by random number table method, with 30 cases in each group. Group A was treated with glycerin sodium chloride and neurotrophic drugs, and group B and group C were treated with 20 % mannitol 250 ml and 125 ml intravenous infusion on the basis of group A. The clinical therapeutic effect, bleeding volume, hematoma volume, neurological deficit (NIHSS) score, daily living ability (ADL) classification and clinical adverse reactions were compared among the three groups.Results The total effective rate of group B and group C was higher than that of group A (P<0.05); while there was no significant difference in the total effective rate between group C and group B (P>0.05). The amount of bleeding in group B and group C was less than that in group A (P<0.05); while there was no significant difference in the amount of bleeding between group C and group B (P>0.05); the hematoma volume of group B and group C was smaller than that of group A, and that of group C was smaller than that of group B (P<0.05). NIHSS scores of group B and group C were lower than those of group A (P<0.05); while there was no significant difference in the NIHSS scores between group C and group B (P>0.05). The proportion of ADLⅠ-Ⅲ in group C and group B was higher than that in group A, and the proportion of ADL Ⅳ-Ⅴ was lower than that in group A, and the proportion of ADLⅠ-Ⅲ in group C was higher than that in group B, and the proportion of ADL Ⅳ-Ⅴ was lower than that in group B (P<0.05). During treatment and observation, the incidence of adverse reactions in group C was lower than that in group B and group A (P<0.05).Conclusion Different doses of mannitol have the same effect on reducing intracranial pressure in the treatment of hypertensive cerebral hemorrhage. However, compared with 250 ml of mannitol, 125 ml of mannitol can effectively improve the classification of daily living ability, reduce hematoma and reduce the incidence of adverse reactions.

参考文献/References:

[1]张令,牟连生.高血压性脑出血早期颅内压监测的意义[J].重庆医学,2018,47(33):4288-4291.[2]郭银章.甘露醇治疗高血压性脑出血血肿扩大的疗效分析[J].深圳中西医结合杂志,2018,28(13):143-144.[3]吴变歌.早期应用甘露醇治疗对高血压性脑出血血肿扩大的疗效观察[J].山西职工医学院学报,2018,28(2):79-81.[4]Moulin S,Cordonnier C.Prognosis and Outcome of Intrac- erebral Haemorrhage[J].Front Neurol Neurosci,2016,37(11):182-192.[5]杨朔,李辉,许秋常.甘露醇治疗早期脑出血对血肿扩大及预后的影响[J].中国实用医药,2018,13(9):113-115.[6]陈建玲,谈晓侠,刘会玲.甘露醇用量和疗程与高血压性脑出 血后迟发性水肿的关系[J].中国药业,2016,25(3):26-29.[7]李伟,陈水钰,顾翔,等.高血压脑出血术后颅内高压应用高渗盐水与甘露醇治疗的效果研究[J].中外医疗,2017,36(14):63-65.[8]张斌,周家强,何惟高,等.甘露醇在控制高血压性脑出血患者早期血肿扩大中的影响评估[J].中国现代医生,2017,55(13):7-10.[9]宋剑飞.高血压性脑出血早期甘露醇不同剂量的降颅压效果差异分析[J].中国医药指南,2020,18(5):143-145.[10]任杰.甘露醇治疗早期脑出血对血肿扩大及预后的影响[J].罕少疾病杂志,2017,24(4):31-32.[11]王莉,王东兴.甘露醇联合单唾液酸神经节苷脂治疗高血压性脑出血的临床效果[J].河南医学研究,2020,29(9):1652-1653.[12]廖永亮.脑出血患者早期应用甘露醇治疗的临床疗效分析[J].北方药学,2016,3(2):62.[13]张健.脑出血患者早期应用甘露醇治疗的临床疗效研究[J].中国农村卫生,2017,6(17):61. [14]李英琴,薛莉娜.不同剂量甘露醇治疗脑出血的临床效果[J].临床医学研究与实践,2019,4(15):23-25. [15]张兴业,贺延莉.甘露醇治疗急性脑出血患者血清血管内皮生长因子、肿瘤坏死因子-α水平的动态变化及其与脑水肿的相关性[J].实用临床医药杂志,2019,23(16):4-7.[16]朱琳琳,潘雷灵,鲁静琦.甘露醇不同静脉滴注速度对急性脑出血患者治疗效果的影响[J].中国医院用药评价与分析,2019,19(3):322-324.[17]李敏捷,吕钊,张鹏.桃核承气汤结合甘露醇治疗高血压性脑出血急性期脑水肿的临床研究[J].实用老年医学,2018,32(9):849-851.[18]殷志国.不同剂量甘露醇对老年急性脑出血的治疗效果分析[J].中国卫生标准管理,2017,8(1):73-74.[19]郑海燕,吴锐,唐晓.不同剂量甘露醇治疗脑出血的临床效果对比[J].中外医学研究,2016,14(7):52-53.

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更新日期/Last Update: 1900-01-01