[1]丁晓燕,丁惠芳.支气管哮喘患儿缓解期呼出气一氧化氮水平与肺功能的相关性研究[J].医学信息,2021,34(24):68-72.[doi:10.3969/j.issn.1006-1959.2021.24.014]
　DING Xiao-yan,DING Hui-fang.Correlation Between Respiratory Nitric Oxide Level and Lung Function in Children with Bronchial Asthma During Remission Period[J].Medical Information,2021,34(24):68-72.[doi:10.3969/j.issn.1006-1959.2021.24.014]
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支气管哮喘患儿缓解期呼出气一氧化氮水平与肺功能的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年24期
页码:
68-72
栏目:
论著
出版日期:
2021-12-15

文章信息/Info

Title:
Correlation Between Respiratory Nitric Oxide Level and Lung Function in Children with Bronchial Asthma During Remission Period
文章编号:
1006-1959（2021）24-0068-05
作者:
丁晓燕; 丁惠芳
（丹阳市妇幼保健院儿科，江苏 丹阳 212300）
Author(s):
DING Xiao-yan; DING Hui-fang
(Department of Pediatrics,Danyang Maternal and Child Health Hospital,Danyang 212300,Jiangsu,China)
关键词:
支气管哮喘; 呼出气一氧化氮; 肺功能; 外周血嗜酸性粒细胞计数
Keywords:
Bronchial asthma; Exhaled nitric oxide; Lung function; Peripheral blood eosinophil count
分类号:
R56
DOI:
10.3969/j.issn.1006-1959.2021.24.014
文献标志码:
A
摘要:
目的 探究支气管哮喘缓解期的患儿呼出气一氧化氮（FeNO）水平与肺功能相关性，分析FeNO等指标对肺功能损伤的诊断预测价值。方法 选取2020年5月-2021年3月我院收治的45例缓解期支气管哮喘儿童纳入观察组，另选同期健康体检儿童45例纳入对照组，比较两组儿童FeNO、外周血嗜酸性粒细胞计数（EOS）、免疫球蛋白（IgE）水平，同时使用FEV1、FEV1/FVC指标水平评价两组儿童的肺功能。利用Spearman相关性分析探究各指标之间的相关性。依据患者的FEV1/FVC指标水平高低分组，采用单因素和多因素Logistic回归分析法探究FeNO、EOS、IgE水平的回归系数，建立联合预测因子X，给出诊断支气管哮喘缓解期的患儿存在肺功能损伤的几率计算公式并进行验证。结果 观察组FeNO、EOS、IgE水平高于对照组，肺功能指标FEV1、FEV1/FVC水平低于对照组正常儿童（P＜0.05）；Spearman相关性分析结果显示，FeNO水平与FEV1、FEV1/FVC水平均呈现显著性负相关，与EOS、IgE水平均呈现显著性正相关（r=-0.652、-0.759、 0.748、0.491，P＜0.05）；Logistic回归分析结果显示，FeNO、EOS、IgE均为支气管哮喘缓解期的患儿存在肺功能损伤的独立风险因素，联合预测因子的曲线下面积最大（AUC=0.829），诊断临界值为-0.385。结论 支气管哮喘缓解期患儿的FeNO水平与其肺功能发生损伤存在密切相关，随着FeNO水平的升高，肺功能损伤可能越严重。但联合应用EOS、IgE水平进行检测，可进一步提高肺功能损伤的预防几率，当联合预测因子的诊断值≥-0.385时，即可预测肺功能发生损伤，因此可进行有效的早期防范与干预，进而减少肺功能损伤的发生，进一步减轻哮喘程度，提高患者生活质量。
Abstract:
Objective To explore the correlation between exhaled nitric oxide (FeNO) level and lung function in children with bronchial asthma in remission stage, and to explore the diagnostic and predictive value of FeNO and other indicators on lung function injury.Methods Forty-five children with bronchial asthma in remission stage admitted to our hospital from May 2020 to March 2021 were selected as the observation group, and 45 healthy children in the same period were selected as the control group. The levels of FeNO, peripheral blood eosinophil (EOS) and immunoglobulin (IgE) were compared between the two groups. The levels of FEV1 and FEV1/FVC were used to evaluate the lung function of the two groups. Spearman correlation analysis was used to explore the correlation between the indicators. According to the FEV1/FVC index level of children, the regression coefficients of FeNO, EOS and IgE levels were explored by single factor and multi-factor Logistic regression analysis, and the combined predictor X was established. The formula for calculating the probability of lung function damage in children with bronchial asthma in remission was given and verified.Results The levels of FeNO, EOS and IgE in the observation group were higher than those in the control group, and the levels of FEV1 and FEV1/FVC were lower than those in the control group (P<0.05). Spearman correlation analysis showed that FeNO levels were negatively correlated with FEV1 and FEV1/FVC levels, and positively correlated with EOS and IgE levels (r=-0.652, -0.759, 0.748, 0.491, P<0.05). Logistic regression analysis showed that FeNO, EOS and IgE were independent risk factors for lung function injury in children with bronchial asthma in remission stage. The area under the curve of combined prediction factor was the largest (AUC=0.829), and the diagnostic critical value was -0.385.Conclusion FeNO level is closely related to lung function injury in children with bronchial asthma in remission stage. With the increase of FeNO level, lung function injury may become more serious. But the combined use of EOS, IgE level for testing can further improve the risk prevention of lung function damage, when the predictors of diagnostic value is -0.385 or higher, the pulmonary function injury can be predicted. Therefore, effective early prevention and intervention can be carried out to reduce the occurrence of pulmonary function injury, further reduce the degree of asthma and improve the quality of life of patients.

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更新日期/Last Update: 1900-01-01