[1]肖 健.静脉溶栓桥接动脉内取栓治疗颅内血管闭塞的临床效果及安全性观察[J].医学信息,2021,34(24):117-119.[doi:10.3969/j.issn.1006-1959.2021.24.029]
　XIAO Jian.Clinical Effect and Safety of Intravenous Thrombolysis Bridging Artery Embolization in the Treatment of Intracranial Vascular Occlusion[J].Medical Information,2021,34(24):117-119.[doi:10.3969/j.issn.1006-1959.2021.24.029]
点击复制

静脉溶栓桥接动脉内取栓治疗颅内血管闭塞的临床效果及安全性观察()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年24期
页码:
117-119
栏目:
临床研究
出版日期:
2021-12-15

文章信息/Info

Title:
Clinical Effect and Safety of Intravenous Thrombolysis Bridging Artery Embolization in the Treatment of Intracranial Vascular Occlusion
文章编号:
1006-1959（2021）24-0117-03
作者:
肖 健
（宁都县人民医院神经内科，江西 宁都 342800）
Author(s):
XIAO Jian
(Department of Neurology,Ningdu County People’s Hospital,Ningdu 342800,Jiangxi,China)
关键词:
静脉溶栓; 桥接动脉内取栓术; 颅内血管闭塞
Keywords:
Intravenous thrombolysis; Bridge artery thrombectomy; Intracranial vascular occlusion
分类号:
R743
DOI:
10.3969/j.issn.1006-1959.2021.24.029
文献标志码:
A
摘要:
目的 观察静脉溶栓桥接动脉内取栓治疗颅内血管闭塞的临床效果及安全性。方法 选取2018年1月-2021年5月在我院治疗的72例颅内血管闭塞患者为研究对象，采用随机数字表法分为对照组和观察组，各36例。对照组采用阿替普酶静脉溶栓治疗，观察组在对照组基础上给予桥接动脉内取栓术联合抽吸治疗。比较两组临床静脉和动脉再通时间、血管再通率、神经功能缺损（NIHSS）评分、取栓次数、改良Rankin预后评分以及并发症发生情况。结果 观察组静脉和动脉再通时间均短于对照组，差异有统计学意义（P＜0.05）。观察组血管再通率为94.44%，高于对照组的83.33%，差异有统计学意义（P＜0.05）。术后，两组NIHSS评分均低于术前，且观察组低于对照组，差异有统计学意义（P＜0.05）。观察组平均取栓次数、改良Rankin预后评分均低于对照组，差异有统计学意义（P＜0.05）。观察组并发症发生率为8.33%，低于对照组的19.44%，差异有统计学意义（P＜0.05）。结论 静脉溶栓桥接动脉内支架联合抽吸取栓术治疗颅内血管闭塞的临床效果理想，可提高血管再通率，缩短血管再通时间，降低神经功能缺损评分，减少取栓次数，改善预后，且并发症发生率少，是一种有效、安全的治疗方法。
Abstract:
Objective To observe the clinical effect and safety of intravenous thrombolysis bridging artery embolization in the treatment of intracranial vascular occlusion.Methods A total of 72 patients with intracranial vascular occlusion treated in our hospital from January 2018 to May 2021 were selected as subjects. They were divided into control group and observation group by random number table method, with 36 cases in each group. The control group was treated with intravenous thrombolysis with alteplase, and the observation group was treated with bridging artery thrombectomy combined with aspiration on the basis of the control group. The clinical venous and arterial recanalization time, recanalization rate, NIHSS score, number of thrombectomy, modified Rankin prognostic score and complications were compared between the two groups.Results The vein and artery recanalization time in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05). The recanalization rate in the observation group was 94.44%, which was higher than 83.33% in the control group, and the difference was statistically significant (P<0.05). After operation, the NIHSS scores of the two groups were lower than those before operation, and those of the observation group were lower than the control group, the differences were statistically significant (P<0.05). The average number of embolectomy and improved Rankin prognosis score in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of complications in the observation group was 8.33%, which was lower than 19.44% in the control group, and the difference was statistically significant (P<0.05).Conclusion The clinical effect of intravenous thrombolysis bridging artery stent combined with thrombus aspiration in the treatment of intracranial vascular occlusion is ideal, which can improve the recanalization rate, shorten the recanalization time, reduce the neurological deficit score, reduce the number of thrombus extraction, and improve the prognosis. It is an effective and safe treatment method with fewer complications.

参考文献/References:

[1]李桂林,杜世伟,李静伟,等.Solitaire FR支架机械取栓联合5F Navien导管抽吸技术治疗大脑中动脉急性闭塞的效果分析[J].中国脑血管病杂志,2017,14(1):37-42.[2]Chueh JY,Puri AS,Wakhloo AK,et al.Risk of distal embolization with stent retriever thrombectomy and ADAPT[J].J Neurointerv Surg,2016,8(2):197-202.[3]高培龙,孙世中,孙洪涛,等.静脉溶栓桥接血管介入治疗急性颅内大动脉闭塞的临床疗效观察:附7例报告[J].中国中西医结合急救杂志,2017,24(2):151-154.[4]胡杨真,胡列计,黄婉洁.阿替普酶静脉溶栓桥接Solitaire AB支架取栓术治疗急性脑梗死的疗效分析[J].卒中与神经疾病,2019,26(2):148-152.[5]唐思治,彭子娟.急性大血管闭塞性卒中单纯取栓和桥接治疗的疗效观察[J].河北医学,2018,24(12):2073-2074.[6]黄文立,宫淑杰,吴志生,等.急性脑梗死合并前循环大血管闭塞患者桥接治疗和机械取栓临床的效果分析[J].中风与神经疾病杂志,2019,36(2):147-149.[7]周晓宇,王珏,余静,等.动静脉桥接与单纯机械取栓治疗急性前循环大动脉闭塞疗效比较[J].医学临床研究,2018,35(6):1218-1221.[8]黎宏庄,游文霞,李国兴.SolitaireTM AB取栓与尿激酶静脉溶栓治疗急性颅内大动脉闭塞的效果比较[J].广东医学,2016,37(7):1060-1063.[9]刘春梅,周俊山,张羽乔,等.静脉溶栓与桥接治疗颅内大动脉闭塞性脑梗死的临床疗效与安全性[J].临床神经病学杂志,2018,31(6):409-413.[10]肖文,蒲晓龙,柏杖勇,等.动静脉联合溶栓与机械取栓治疗急性脑 梗死的临床疗效及对患者预后的影响[J].河北医学,2017,23(9):1498-1502.[11]Kaesmacher J,Kleine JF.Bridging Therapy with i. v. rtPA in MCA Occlusion Prior to Endovascular Thrombectomy: a Double-Edged Sword?[J].Clin Neuroradiol,2018,28(1):81-89.[12]赵立伟,宋彧琳,周丹,等.发病时间≥4.5 h急性前循环大血管闭塞性脑梗死静脉溶栓的疗效观察[J].中国冶金工业医学杂志,2019,36(3):275-276.[13]常晓赞,杨鹏飞,张磊,等.大脑中动脉高密度征对急性大血管闭塞性缺血性卒中取栓治疗的意义[J].中国微侵袭神经外科杂志,2019,24(5):212-215.[14]黄文立,宫淑杰,吴志生,等.急性脑梗死合并前循环大血管闭塞患者桥接治疗和机械取栓临床的效果分析[J].中风与神经疾病杂志,2019,36(2):147-149.[15]唐思治,彭子娟.急性大血管闭塞性卒中单纯取栓和桥接治疗的疗效观察[J].河北医学,2018,24(12):2073-2076.[16]张莉.静脉溶栓桥接动脉内取栓治疗颅内大血管急性闭塞的效果观察[J].临床研究,2018,26(10):85-86.[17]沈媛,侍海存,宋远营,等.颅内大血管闭塞致急性缺血性卒中多模式血管内治疗研究[J].中国现代神经疾病杂志,2018,18(5):355-359.[18]李桂林,杜世伟,李静伟,等.静脉溶栓桥接动脉内取栓治疗颅内大血管急性闭塞的效果分析[J].中国脑血管病杂志,2017,14(3):122-126.[19]齐宝柱,呼铁民,王广,等.Solitaire AB支架治疗急性后循环大血管闭塞预后的影响因素[J].实用医学杂志,2019,35(7):1110-1115.[20]李刚,李宏宇.支架取栓术对急性基底动脉闭塞取栓效果和神经功能评分研究[J].中国继续医学教育,2017,9(23):78-79.

相似文献/References:

[1]王 伟,宫秀群,余 亮.阿替普酶治疗急性脑梗死患者临床转归的影响因素[J].医学信息,2022,35(11):84.[doi:10.3969/j.issn.1006-1959.2022.11.022]
　WANG Wei,GONG Xiu-qun,YU Liang.The Influencing Factors of Clinical Outcome in Patients with Acute Cerebral Infarction Treated with Alteplase[J].Medical Information,2022,35(24):84.[doi:10.3969/j.issn.1006-1959.2022.11.022]
[2]褚春沐.阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的效果及对脑血管储备功能的影响[J].医学信息,2022,35(13):133.[doi:10.3969/j.issn.1006-1959.2022.13.031]
　CHU Chun-mu.Effect of Argatroban Combined with Alteplase Intravenous Thrombolysis on Acute Cerebral Infarction and its Effect on Cerebrovascular Reserve Function[J].Medical Information,2022,35(24):133.[doi:10.3969/j.issn.1006-1959.2022.13.031]
[3]赵东慧.阿替普酶静脉溶栓联合氯吡格雷对急性脑梗死患者脑血流动力学及CRP、Hcy、HDL-C水平的影响[J].医学信息,2022,35(20):74.[doi:10.3969/j.issn.1006-1959.2022.20.018]
　ZHAO Dong-hui.Effect of Alteplase Intravenous Thrombolysis Combined with Clopidogrel on Cerebral Hemodynamics and Levels of CRP, Hcy and HDL-C in Patients with Acute Cerebral Infarction[J].Medical Information,2022,35(24):74.[doi:10.3969/j.issn.1006-1959.2022.20.018]
[4]宋贵军.急性缺血性脑卒中静脉溶栓治疗[J].医学信息,2020,33(17):47.[doi:10.3969/j.issn.1006-1959.2020.17.014]
　SONG Gui-jun.Intravenous Thrombolytic Therapy for Acute Ischemic Stroke[J].Medical Information,2020,33(24):47.[doi:10.3969/j.issn.1006-1959.2020.17.014]
[5]周 跃,高永超.阿替普酶早期静脉溶栓治疗急性脑梗塞对患者凝血功能、氧化炎症反应及神经功能的影响[J].医学信息,2022,35(03):156.[doi:10.3969/j.issn.1006-1959.2022.03.041]
　ZHOU Yue,GAO Yong-chao.Effect of Early Intravenous Thrombolysis with Alteplase on Coagulation Function,Oxidative Inflammatory Response and Neurological Function in Patients with Acute Cerebral Infarction[J].Medical Information,2022,35(24):156.[doi:10.3969/j.issn.1006-1959.2022.03.041]
[6]赵东慧,王 楠,杨思远.阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及对脑血管储备功能的影响[J].医学信息,2023,36(13):151.[doi:10.3969/j.issn.1006-1959.2023.13.033]
　ZHAO Dong-hui,WANG Nan,YANG Si-yuan.Effect of Argatroban Combined with Alteplase Intravenous Thrombolysis on Acute Cerebral Infarction and its Effect on Cerebrovascular Reserve Function[J].Medical Information,2023,36(24):151.[doi:10.3969/j.issn.1006-1959.2023.13.033]

更新日期/Last Update: 1900-01-01