[1]匡萃峰,肖叙平,刘小飞.血清肿瘤标志物检测在肺癌诊断中的应用价值[J].医学信息,2021,34(24):181-183.[doi:10.3969/j.issn.1006-1959.2021.24.049]
　KUANG Cui-feng,XIAO Xu-ping,LIU Xiao-fei.Application Value of Serum Tumor Markers in Diagnosis of Lung Cancer[J].Medical Information,2021,34(24):181-183.[doi:10.3969/j.issn.1006-1959.2021.24.049]
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血清肿瘤标志物检测在肺癌诊断中的应用价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年24期
页码:
181-183
栏目:
诊疗技术
出版日期:
2021-12-15

文章信息/Info

Title:
Application Value of Serum Tumor Markers in Diagnosis of Lung Cancer
文章编号:
1006-1959（2021）24-0181-03
作者:
匡萃峰; 肖叙平; 刘小飞
（泰和县人民医院检验科，江西 泰和 343700）
Author(s):
KUANG Cui-feng; XIAO Xu-ping; LIU Xiao-fei
(Department of Laboratory,Taihe County People’s Hospital,Taihe 343700,Jiangxi,China)
关键词:
肺癌; 血清肿瘤标志物; 细胞角蛋白片段21-1; 糖类抗原125
Keywords:
Lung cancer; Serum tumor markers; Cytokeratin fragment 21-1; Carbohydrate antigen 125
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2021.24.049
文献标志码:
A
摘要:
目的 研究血清肿瘤标志物检测在肺癌诊断中的应用价值。方法 选取2019年7月-2021年6月泰和县人民医院诊治的82例肺癌患者设为观察组，另选取同期我院健康体检者80名设为对照组，均进行血清肿瘤标志物[细胞角蛋白片段21-1（CYFRA21-1）、糖类抗原125（CA125）、糖类抗原199（CA199）、癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）]检测，比较两组血清肿瘤标志物阳性检出率、各标志物平均水平、不同分期各标志物水平以及单项各标志物检测与联合检测肺癌的诊断敏感度、特异度和准确度。结果 观察组CYFRA21-1、CA125、CA199、CEA、NSE阳性率均高于对照组，差异有统计学意义（P＜0.05）；观察组CYFRA21-1、CA125、CA199、CEA、NSE水平均高于对照组，差异有统计学意义（P＜0.05）；不同分期肺癌CYFRA21-1、CA125、CA199、CEA、NSE水平比较，差异有统计学意义（P＜0.05），且分期越高，血清肿瘤标志物水平越高；联合检测敏感度、特异度和准确度均高于CYFRA21-1、CA125、CA199、CEA、NSE各标志物单独检测（P＜0.05）。结论 血清肿瘤标志物检测在肺癌诊断中具有较高的价值，且可对肺癌分期起到一定的预测作用，同时血清肿瘤标志物联合检测诊断敏感度、特异度和准确度均较高，可为临床治疗效果、预后评估发挥积极的参考作用。
Abstract:
Objective To study the application value of serum tumor markers in the diagnosis of lung cancer.Methods Totally 82 patients with lung cancer diagnosed and treated in Taihe County People ’s Hospital from July 2019 to June 2021 were selected as the observation group, and 80 healthy subjects were selected as the control group. Serum tumor markers [cytokeratin fragment 21-1 (CYFRA21-1), carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), neuron specific enolase (NSE)] were detected. The positive detection rate of serum tumor markers, the average level of each marker, the levels of each marker in different stages and the diagnostic sensitivity, specificity and accuracy of single marker detection and combined detection of lung cancer were compared between the two groups.Results The positive rates of CYFRA21-1, CA125, CA199, CEA and NSE in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The levels of CYFRA21-1, CA125, CA199, CEA and NSE in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The levels of CYFRA21-1, CA125, CA199, CEA and NSE in lung cancer at different stages were compared, and the differences were statistically significant (P<0.05), and serum tumor markers gradually increased with the increase of stage. The sensitivity, specificity and accuracy of combined detection were higher than those of CYFRA21-1, CA125, CA199, CEA and NSE alone (P<0.05).Conclusion The detection of serum tumor markers has a high value in the diagnosis of lung cancer, and can play a certain role in predicting the staging of lung cancer. At the same time, the sensitivity, specificity and accuracy of combined detection of serum tumor markers are high, which can play a positive reference role for the clinical treatment effect and prognosis evaluation.

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更新日期/Last Update: 1900-01-01