[1]孙 露,梁若飞.基于数据库分析TRIM47基因在胶质母细胞瘤中的表达及其临床意义[J].医学信息,2022,35(04):6-9.[doi:10.3969/j.issn.1006-1959.2022.04.002]
 SUN Lu,LIANG Ruo-fei.Expression of TRIM47 Gene in Glioblastoma Based on Database Analysis and its Clinical Significance[J].Medical Information,2022,35(04):6-9.[doi:10.3969/j.issn.1006-1959.2022.04.002]
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基于数据库分析TRIM47基因在胶质母细胞瘤中的表达及其临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年04期
页码:
6-9
栏目:
出版日期:
2022-02-15

文章信息/Info

Title:
Expression of TRIM47 Gene in Glioblastoma Based on Database Analysis and its Clinical Significance
文章编号:
1006-1959(2022)04-0006-04
作者:
孙 露1梁若飞12
1.川北医学院临床医学系,四川 南充 637100;2.川北医学院附属医院神经外科,四川 南充 637002
Author(s):
SUN Lu1LIANG Ruo-fei12
1.Department of Clinical Medicine,North Sichuan Medical College,Nanchong 637100,Sichuan,China;2.Department of Neurosurgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637002,Sichuan,China
关键词:
TRIM47多形性胶质瘤总生存期无病生存期
Keywords:
TRIM47Glioblastoma multiformeOverall survivalDisease-free survival
分类号:
R739.41;R730.231
DOI:
10.3969/j.issn.1006-1959.2022.04.002
文献标志码:
A
摘要:
目的 探讨TRIM47(tripartite motif 47)在多形性胶质母细胞瘤(GBM)中的表达及其临床意义。方法 于ONCOMINE数据库和GEPIA数据库中检索关于TRIM47的信息,并对获得的资料进行整合,分析TRIM47在GBM与正常对照组中的表达情况,通过GEPIA数据库分析TRIM47在GBM中的表达与预后的相关性。结果 GBM中TRIM47的mRNA表达高于正常对照组,差异有统计学意义(P<0.05);TRIM47基因水平低表达者总生存期较高表达者更长(HR=1.8,P=0.0014),而对患者的无病生存期无影响(HR=1.1,P=0.64)。结论 TRIM47基因在GBM组织中呈高表达,其表达水平对GBM患者预后的预测具重要意义。
Abstract:
Objective To investigate the expression of tripartite motif 47(TRIM47) in glioblastoma multiforme(GBM) and its clinical significance.Methods The information about TRIM47 was retrieved from ONCOMINE database and GEPIA database, and the obtained data were integrated to analyze the expression of TRIM47 in GBM and normal control group. The correlation between the expression of TRIM47 in GBM and prognosis was analyzed by GEPIA database.Results The mRNA expression of TRIM47 in GBM was higher than that in the normal control group, and the difference was statistically significant (P<0.05). Patients with low TRIM47 gene expression had longer overall survival (HR=1.8, P=0.0014), but had no effect on disease-free survival (HR=1.1, P=0.64).Conclusion TRIM47 gene is highly expressed in GBM tissues, and its expression level is of great significance in predicting the prognosis of GBM.

参考文献/References:

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更新日期/Last Update: 1900-01-01