[1]汪 梅,李 丽,任咏惠,等.去甲基化药物联合预激方案在骨髓增生异常综合征中的应用[J].医学信息,2022,35(06):41-44.[doi:10.3969/j.issn.1006-1959.2022.06.010]
 WANG Mei,LI Li,REN Yong-hui,et al.Application of Demethylated Drugs Combined with Preexcitation Regimen in Myelodysplastic Syndrome[J].Medical Information,2022,35(06):41-44.[doi:10.3969/j.issn.1006-1959.2022.06.010]
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去甲基化药物联合预激方案在骨髓增生异常综合征中的应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年06期
页码:
41-44
栏目:
综述
出版日期:
2022-03-15

文章信息/Info

Title:
Application of Demethylated Drugs Combined with Preexcitation Regimen in Myelodysplastic Syndrome
文章编号:
1006-1959(2022)06-0041-04
作者:
汪 梅李 丽任咏惠
(1.牡丹江医学院研究生处,黑龙江 牡丹江 157011;2.牡丹江医学院附属红旗医院血液科,黑龙江 牡丹江 157011)
Author(s):
WANG MeiLI LiREN Yong-huiet al.
(1.Graduate Department,Mudanjiang Medical College,Mudanjiang 157011,Heilongjiang,China;2.Department of Hematology,Hongqi Hospital Affiliated to Mudanjiang Medical College,Mudanjiang 157011,Heilongjiang,China)
关键词:
去甲基化药物预激方案骨髓增生异常综合征
Keywords:
Demethylation drugsPreexcitation schemeMyelodysplastic syndrome
分类号:
R551.3
DOI:
10.3969/j.issn.1006-1959.2022.06.010
文献标志码:
A
摘要:
骨髓增生异常综合征(MDS)是一组起源于造血干细胞,以血细胞病态造血,高风险向急性髓系白血病(AML)转化为特征的异质性髓系肿瘤性疾病。去甲基化药物经诱导蛋白酶体降解,共价与DNA甲基转移酶(DNMT)结合,使DNA甲基化状态解除,在治疗MDS上已得到普遍认可且已广泛应用于临床。研究表明,去甲基化药物联合预激方案在治疗中、高危MDS中能够增强化疗药物的疗效,更好的发挥协同作用,提高患者的生存质量及预后。本文主要多甲基化药物的作用机制及分类、地西他滨联合预激方案、阿扎胞苷联合预激方案在治疗MDS中的作用进行综述,以期为临床治疗MDS提供参考。
Abstract:
Myelodysplastic syndrome (MDS) is a group of heterogeneous myeloid neoplastic diseases, which originated from hematopoietic stem cells and characterized by pathological hematopoiesis of blood cells and high risk of transforming into acute myeloid leukemia (AML). Demethylation drugs are induced to degrade proteasome, and covalently bind to DNA methyltransferase (DNMT) to relieve DNA methylation status, which has been widely recognized in the treatment of MDS and has been widely used in clinical practice. With the further clinical research on middle- and high-risk MDS, it has been shown that demethylated drugs combined with pre-excitation regimen can enhance the efficacy of chemotherapy drugs in the treatment of middle- and high-risk MDS, better play a synergistic effect, improve the quality of life of patients and prolong their survival time. This article reviews the mechanism and classification of demethylating drugs, decitabine combined with preexcitation regimen, and azacytidine combined with preexcitation regimen in the treatment of MDS, in order to further clarify the application effect of demethylating drugs in MDS.

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更新日期/Last Update: 1900-01-01