[1]李建一.奥美拉唑与兰索拉唑治疗成人活动期胃溃疡的临床疗效及对溃疡愈合的影响[J].医学信息,2022,35(08):156-158.[doi:10.3969/j.issn.1006-1959.2022.08.040]
　LI Jian-yi.Clinical Efficacy of Omeprazole and Lansoprazole in the Treatment of Active Gastric Ulcer in Adults and its Effect on Ulcer Healing[J].Medical Information,2022,35(08):156-158.[doi:10.3969/j.issn.1006-1959.2022.08.040]
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奥美拉唑与兰索拉唑治疗成人活动期胃溃疡的临床疗效及对溃疡愈合的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年08期
页码:
156-158
栏目:
药物与临床
出版日期:
2022-04-15

文章信息/Info

Title:
Clinical Efficacy of Omeprazole and Lansoprazole in the Treatment of Active Gastric Ulcer in Adults and its Effect on Ulcer Healing
文章编号:
1006-1959（2022）08-0156-03
作者:
李建一
（天津市蓟州区人民医院妇科，天津 301900）
Author(s):
LI Jian-yi
(Department of Spleen and Stomach Diseases,Tianjin Wuqing District Hospital of Traditional Chinese Medicine,Tianjin 301700,China)
关键词:
米非司酮周期疗法; 孕激素; 围绝经期; 异常子宫出血
Keywords:
Omeprazole; Lansoprazole; Active gastric ulcer; Gastric mucosa
分类号:
R711.52
DOI:
10.3969/j.issn.1006-1959.2022.08.040
文献标志码:
A
摘要:
目的 观察米非司酮周期疗法与孕激素治疗围绝经期异常子宫出血的临床效果。方法 选取2020年6月-2021年6月在我院诊治的72例围绝经期异常子宫出血患者为研究对象，采用随机数字表法分为对照组和观察组，各36例。对照组采用孕激素治疗，观察组采用米非司酮周期疗法治疗，比较两组临床疗效、子宫内膜厚度、月经周期、出血控制时间、性激素水平以及不良反应发生情况。结果 观察组治疗总有效率为88.89%，高于对照组的77.78%，差异有统计学意义（P＜0.05）；两组子宫内膜厚度均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组出血控制时间、月经周期短于对照组，差异有统计学意义（P＜0.05）；观察组雌二醇水平低于对照组，卵泡雌激素、黄体生成素均高于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为5.56%，低于对照组的13.89%，差异有统计学意义（P＜0.05）。结论 米非司酮周期疗法治疗围绝经期异常子宫出血总有效率高，可快速控制异常出血，促进月经周期缩短，改善性激素水平，不良反应少，安全性良好。
Abstract:
Objective To observe the clinical efficacy of omeprazole and lansoprazole in the treatment of active gastric ulcer in adults.Methods A total of 64 patients with active gastric ulcer who were treated in our hospital from May 2020 to May 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 32 cases in each group. The control group was treated with omeprazole, and the observation group was treated with lansoprazole. The therapeutic effect, clinical symptom score, ulcer diameter, healing time, incidence of adverse reactions and ulcer healing quality were compared between the two groups.Results The total effective rate of the observation group was 93.75%, which was compared with 90.63% of the control group, the difference was not statistically significant (P>0.05). There was no significant difference in the scores of abdominal pain, abdominal distension, antiacidity and burning sensation between the two groups (P>0.05). The ulcer diameter and ulcer healing time in the observation group were less than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The improvement rate of gland density and gland tube morphology in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05).Conclusion Omeprazole and lansoprazole have good efficacy in the treatment of active gastric ulcer in adults, both of them have no obvious advantages and disadvantages in clinical symptom score and adverse reactions, but lansoprazole has better effect in the treatment of ulcer healing and has certain application advantages.

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更新日期/Last Update: 1900-01-01