[1]崔姗姗,刘 英,江 霞.非酒精性脂肪性肝病与胰岛素抵抗的研究进展[J].医学信息,2022,35(10):66-69.[doi:10.3969/j.issn.1006-1959.2022.10.016]
 CUI Shan-shan,LIU Ying,JIANG Xia.Research Progress on Non-alcoholic Fatty Liver Disease and Insulin Resistance[J].Medical Information,2022,35(10):66-69.[doi:10.3969/j.issn.1006-1959.2022.10.016]
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非酒精性脂肪性肝病与胰岛素抵抗的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
66-69
栏目:
综述
出版日期:
2022-05-15

文章信息/Info

Title:
Research Progress on Non-alcoholic Fatty Liver Disease and Insulin Resistance
文章编号:
1006-1959(2022)10-0066-04
作者:
崔姗姗刘 英江 霞
(天津市第一中心医院内分泌与代谢科,天津 300010)
Author(s):
CUI Shan-shanLIU YingJIANG Xia
(Department of Endocrinology and Metabolism,Tianjin First Central Hospital,Tianjin 300010,China)
关键词:
非酒精性脂肪性肝病胰岛素抵抗肥胖
Keywords:
Nonalcoholic fatty liver diseaseInsulin resistanceObesity
分类号:
R575.5
DOI:
10.3969/j.issn.1006-1959.2022.10.016
文献标志码:
A
摘要:
非酒精性脂肪性肝病是临床常见的肝病之一,尤其是随着饮食结构和生活方式的改变,其发生率不断上升。非酒精性脂肪性肝病发病机制较为复杂,具体机制尚未完全明确,目前普遍认为与遗传、环境、代谢密切相关。研究显示,胰岛素抵抗与非酒精性脂肪性肝病的发生、发展密切相关。本文主要综述胰岛素抵抗与非酒精性脂肪性肝病相关的脂肪因子以及两病的治疗方法,以期为非酒精性脂肪性肝病的预防及治疗提供参考。
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in clinic. The incidence of NAFLD is increasing with the change of diet and lifestyle. The pathogenesis of non-alcoholic fatty liver disease is complex, and the specific mechanism has not been fully clarified. At present, it is generally believed that it is closely related to heredity, environment and metabolism. Studies have shown that insulin resistance is closely related to the occurrence and development of non-alcoholic fatty liver disease. This paper mainly reviews the fat factors related to insulin resistance and non-alcoholic fatty liver disease and the treatment methods of the two diseases, providing reference for the prevention and treatment of non-alcoholic fatty liver disease.

参考文献/References:

[1]周敬华.2型糖尿病合并非酒精性脂肪肝患者血清 nesfatin-1水平与胰岛素抵抗的相关性研究[J].临床合理用药杂志,2016,9(24):1-3.[2]马俊花,孙菲,席倩,等.2型糖尿病合并非酒精性脂肪性肝病患者血清颗粒蛋白前体水平的变化及意义[J].第二军医大学学报,2016,37(8):1033-1037.[3]滕圣智.青海地区非酒精性脂肪肝病患者血清γ-GT、CHE、IR水平测定及临床意义[D].西宁:青海大学,2017.[4]中华医学会肝病学分会脂肪肝和酒精性肝病学组,中国医师协会脂肪性肝病专家委员会.非酒精性脂肪性肝病防治指南(2018 年更新版)[J].临床肝胆病杂志,2018,34(5):947-957.[5]张丽静.HO-1 /CO 通过调控 TLR4 /NF-KB 修复胆汁淤积肝损伤肠屏障破坏的研究[D].大连:大连医科大学,2017.[6]Xu MX,Wang M,Yang WW.Gold-quercetin nanop- articles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4 /NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice[J].Int J Nanomedicine,2017,12:327-345.[7]周正平,陈莉.非酒精性脂肪肝患者细胞因子水平及临床意义[J].现代仪器与医疗,2017,23(1):88-89,97.[8]Lonardo A,Nascimbeni F,Maurantonio M,et al.Nonalcoholic fatty liver disease: Evolving paradigms[J].World J Gastroenterol,2017,23(36):6571-6592.[9]张璞.自噬指标 ATG7、Beclin1 与非酒精性脂肪性肝病的相关性研究[D].石家庄:河北医科大学,2017.[10]徐毓.PXR基因多态性与非酒精性脂肪性肝病遗传易感性的关联性研究[D].广州:广东药科大学,2016.[11]梁健,钟碧莹,汤茵,等.肝纤维化检测在非酒精性脂肪肝诊断中的应用研究[J].中国卫生标准管理,2017,8(17):110-113.[12]杨小花,吴时胜,刘斌,等.还原型谷胱甘肽联合丹参注射液治疗酒精性肝病失代偿期肝硬化患者的临床观察[J].中国中医急症,2017,26(4):671-673.[13]李桂芬,袁静,丁洁.多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝的临床疗效分析[J].医药论坛杂志,2017,38(2):25-26.[14]Lee DY,Park JK,Hur KY,et al.Association between nonalcoholic fatty liver disease and bone mineral density in postmenopausal women[J].Climacteric,2018,21(5):498-501.[15]于宁,高燕燕,咸玉欣,等.艾塞那肽对2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量及血清 chemerin 水平的影响[J].山东大学学报(医学版),2016,54(11):51-55.[16]杨华,杨晓东,饶丽华,等.糖代谢异常患者血清脂肪细胞脂肪酸结合蛋白的变化及其临床意义[J].中国糖尿病杂志,2016,24(4):309-312.[17]张亚杰,靳爽,姜宁,等.塞来昔布对2型糖尿病大鼠非酒精性脂肪肝病相关的胰岛素抵抗的影响[J].中国医科大学学报,2016,45(1):39-44.[18]Xue L,He J,Gao N,et al.Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia[J].Sci Rep,2017,7:45176.[19]常薪霞,张林杉,夏明锋,等.2 型糖尿病伴非酒精性脂肪性肝病患者血常规指标与肝脏脂肪含量的相关性[J].中国临床医学,2019,26(5):692-696.[20]李剑霜,陈芝芸,洪薇.维生素E对非酒精性脂肪性肝病小鼠肝脏SIRT1、PGC-1α表达的影响[J].中国药学杂志,2017,52(12):1029.[21]金春花,赵催春,陈明云,等.糖调节受损患者非酒精性脂肪肝的临床特征[J].江苏医药,2018,44(4):378-380,384. [22]张宇恒,丁素英.转氨酶水平与非酒精性脂肪肝的关系[J].郑州大学学报(医学版),2019,54(6):916-918. [23]张敏,陈璐,瞿美娣,等.2 型糖尿病病人合并非酒精性脂肪性肝病的危险因素分析[J].肠外与肠内营养,2019,26(5):271-275. [24]付淑姣,杨志欣.非酒精性脂肪肝患者血清 HMGB-1、IL-1β、Vaspin水平与 HOMA-IR的相关性研究[J].国际检验医学杂志,2019,40(17):2132-2134,2138.[25]Sun Y,Dai W,Liang Y,et al.Relationship between nonalcoholic fatty liver disease and bone mineral density in adolescents with obesity: a meta-analysis[J].Diabetes Metab Syndr Obes,2019,12:199-207.[26]李柳梅.脂肝方对非酒精性脂肪肝NF-κB-TNF-α/Bcl-2通路的调节效应[J].广西中医药大学学报,2016,30(5):344-345.[27]张瑜,秦波.ω-3多不饱和脂肪酸对非酒精性脂肪肝的治疗作用[J].肝脏,2016,21(11):980-982.[28]马军,宋雨鸿.五苓散对非酒精性脂肪肝病患者血清瘦素水平及胰岛素抵抗指数的影响[J].光明中医,2018,33(16):2389-2392.[29]黄延芹.健脾消渴方对2型糖尿病大鼠胰岛细胞分泌功能的影响[J].中医杂志,2016,56(3):249-252.[30]欧强,徐燕华,曲立娟,等.强肝胶囊对非酒精性脂肪性肝病患者胰岛素抵抗指数和肝纤维化评分的影响[J].临床肝胆病杂志,2016,15(10):114-116.

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更新日期/Last Update: 1900-01-01