[1]金 英.维甲酸联合亚砷酸治疗急性早幼粒细胞白血病的疗效及对患者血清TAT、TM、PIC水平的影响[J].医学信息,2022,35(10):126-129.[doi:10.3969/j.issn.1006-1959.2022.10.030]
　JIN Ying.The Curative Effect of Retinoic Acid Combined with Arsenic Acid in the Treatment of Acute Promyelocytic Leukemia and its Effect on Serum TAT, TM and PIC Levels[J].Medical Information,2022,35(10):126-129.[doi:10.3969/j.issn.1006-1959.2022.10.030]
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维甲酸联合亚砷酸治疗急性早幼粒细胞白血病的疗效及对患者血清TAT、TM、PIC水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
126-129
栏目:
论著
出版日期:
2022-05-15

文章信息/Info

Title:
The Curative Effect of Retinoic Acid Combined with Arsenic Acid in the Treatment of Acute Promyelocytic Leukemia and its Effect on Serum TAT, TM and PIC Levels
文章编号:
1006-1959（2022）10-0126-04
作者:
金 英
（佳木斯市中心医院血液内科，黑龙江 佳木斯 154002）
Author(s):
JIN Ying
(Department of Hematology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
急性早幼粒细胞白血病; 维甲酸; 亚砷酸; 凝血功能
Keywords:
Acute promyelocytic leukemia; Retinoic acid; Arsenious acid; Coagulation function
分类号:
R733.7
DOI:
10.3969/j.issn.1006-1959.2022.10.030
文献标志码:
A
摘要:
目的 探究维甲酸联合亚砷酸治疗急性早幼粒细胞白血病（APL）的临床疗效以及对血清凝血酶－抗凝血酶复合物（TAT）、血栓调节蛋白（TM）、纤溶酶-α2纤溶酶抑制剂复合物（PIC）水平的影响。方法 选择2018年1月-2019年1月于佳木斯市中心医院治疗的80例APL患者为研究对象，采用随机数字表法分为观察组和对照组，各40例。对照组采用维甲酸治疗，观察组在对照组基础上联合亚砷酸治疗，比较两组临床疗效、凝血功能指标（TAT、TM、PIC）、临床指标（临床症状缓解、高白细胞血症持续和异常凝血指标恢复时间）、血液指标（白细胞计数、早幼粒细胞比例）、治疗后1年和2年生存率及不良反应发生情况。结果 观察组总有效率为92.50%，高于对照组的82.50%，差异有统计学意义（P＜0.05）；观察组TAT、TM、PIC水平均低于对照组，差异有统计学意义（P＜0.05）；观察组临床症状缓解时间、高白细胞血症持续时间、异常凝血指标恢复时间均短于对照组，差异有统计学意义（P＜0.05）；观察组白细胞计数、早幼粒细胞比例均低于对照组，差异有统计学意义（P＜0.05）；观察组治疗后1、2年生存率与对照组比较，差异无统计学意义（P＞0.05）；观察组不良反应发生率与对照组比较，差异无统计学意义（P＞0.05）。结论 维甲酸联合亚砷酸治疗APL效果确切，可改善凝血功能，减少白细胞计数和早幼粒细胞比例，缩短临床症状缓解、凝血功能异常恢复以及高白细胞持续时间，且不会增加临床不良反应，是一种安全、有效的治疗方案。
Abstract:
Objective To investigate the clinical efficacy of retinoic acid combined with arsenic acid in the treatment of acute promyelocytic leukemia (APL) and its effect on serum thrombin-antithrombin complex (TAT), thrombomodulin (TM) and plasminogen-α2 plasminogen inhibitor complex (PIC) levels.Methods A total of 80 patients with APL who were treated in Jiamusi Central Hospital from January 2018 to January 2019 were selected as the study subjects. They were divided into observation group and control group by random number table method, with 40 cases in each group. The control group was treated with retinoic acid, and the observation group was treated with arsenic trioxide on the basis of the control group. The clinical efficacy, coagulation function indexes (TAT, TM, PIC), clinical indexes (remission of clinical symptoms, duration of hyperleukemia and recovery time of abnormal coagulation indexes), blood indexes (white blood cell count and promyelocyte ratio), 1-year and 2-year survival rates after treatment, and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 92.50%, which was higher than 82.50% of the control group, and the difference was statistically significant (P<0.05); The levels of TAT, TM and PIC in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05); The remission time of clinical symptoms, duration of hyperleukemia and recovery time of abnormal coagulation indexes in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05); The white blood cell count and the proportion of promyelocyte in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05); There was no significant difference in the 1-year and 2-year survival rates between the observation group and the control group after treatment (P>0.05); There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05).Conclusion Retinoic acid combined with arsenic acid is effective in the treatment of APL, which can improve coagulation function, reduce white blood cell count and promyelocyte ratio, and does not increase clinical adverse reactions. It is a safe and effective treatment plan.

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更新日期/Last Update: 1900-01-01