[1]余 佳.早期胰岛素强化治疗对初诊2型糖尿病患者血糖控制效果及颈动脉粥样硬化进展的影响[J].医学信息,2022,35(10):140-142.[doi:10.3969/j.issn.1006-1959.2022.10.034]
 YU Jia.Effect of Early Intensive Insulin Therapy on Blood Glucose Control and Progression of Carotid Atherosclerosis in Newly Diagnosed Type 2 Diabetic Mellitus Patients[J].Medical Information,2022,35(10):140-142.[doi:10.3969/j.issn.1006-1959.2022.10.034]
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早期胰岛素强化治疗对初诊2型糖尿病患者血糖控制效果及颈动脉粥样硬化进展的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
140-142
栏目:
论著
出版日期:
2022-05-15

文章信息/Info

Title:
Effect of Early Intensive Insulin Therapy on Blood Glucose Control and Progression of Carotid Atherosclerosis in Newly Diagnosed Type 2 Diabetic Mellitus Patients
文章编号:
1006-1959(2022)10-0140-03
作者:
余 佳
(兰州兰石医院内分泌科,甘肃 兰州 730050)
Author(s):
YU Jia
(Department of Endocrinology,Lanzhou Lanshi Hospital,Lanzhou 730050,Gansu,China)
关键词:
2型糖尿病早期胰岛素强化治疗血糖控制效果颈动脉内膜
Keywords:
Type 2 diabetes mellitusEarly intensive insulin therapyBlood glucose control effectCarotid intima
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2022.10.034
文献标志码:
A
摘要:
目的 研究早期胰岛素强化治疗对初诊2型糖尿病(T2DM)患者血糖控制效果及颈动脉粥样硬化进展的影响。方法 回顾性选取2016年1月-2021年1月兰州兰石医院内分泌科收治的92例初诊T2DM患者,其中46例患者采用常规阶梯式治疗设为对照组,另46例行早期胰岛素强化治疗设为观察组。比较两组血糖指标[空腹血糖(FPG)、餐后2 h血糖(2hPBG)、糖化血红蛋白(HbA1c)]、胰岛功能[胰岛素分泌指数(HOMA-β)]、胰岛素抵抗指数(HOMA-IR)]、血糖波动情况[最大血糖波动幅度(LAGE)、餐后血糖波动幅度(PPGE)]、颈动脉内膜-中膜厚度(IMT)及粥样斑块检出情况。结果 观察组FPG、2hPBG、HbA1c水平低于对照组(P<0.05);观察组HOMA-β高于对照组,HOMA-IR低于对照组(P<0.05);观察组LAGE、PPGE指标低于对照组(P<0.05);观察组颈动脉IMT值及斑块检出率小于对照组(P<0.05)。结论 早期胰岛素强化治疗可控制初诊T2DM患者的血糖水平,改善胰岛β细胞功能,避免血糖波动,同时影响粥样斑块的形成,延缓颈动脉粥样硬化进展。
Abstract:
Objective To study the effect of early intensive insulin therapy on blood glucose control and carotid atherosclerosis in newly diagnosed type 2 diabetes mellitus (T2DM) patients.Methods A total of 92 newly diagnosed patients with T2DM admitted to the Endocrinology Department of Lanzhou Lanshi Hospital from January 2016 to January 2021 were retrospectively selected. Among them, 46 patients were treated with conventional step-by-step treatment as the control group, and the other 46 patients were treated with early intensive insulin therapy as the observation group. The blood glucose indexes [fasting plasma glucose (FPG), 2 h postprandial blood glucose (2 hPBG), glycosylated hemoglobin (HbA1c)], islet function [insulin secretion index (HOMA-β)], insulin resistance index (HOMA-IR)], blood glucose fluctuation [maximum blood glucose fluctuation (LAGE), postprandial blood glucose fluctuation (PPGE)], carotid intima-media thickness (IMT) and detection of atherosclerotic plaques were compared between the two groups.Results The levels of FPG, 2hPBG and HbA1c in the observation group were lower than those in the control group (P<0.05). HOMA-β in the observation group was higher than that in the control group, and HOMA-IR was lower than that in the control group(P<0.05). LAGE and PPGE in the observation group were lower than those in the control group(P<0.05). The carotid IMT value and plaque detection rate in the observation group were lower than those in the control group(P<0.05).Conclusion Early intensive insulin therapy can control the blood glucose level of newly diagnosed T2DM patients, improve islet β cell function, avoid blood glucose fluctuation, affect the formation of atherosclerotic plaque and delay the progress of carotid atherosclerosis.

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