[1]王 琼,李 帅.浙江地区健康女性抗心磷脂抗体和抗β2糖蛋白Ⅰ抗体参考区间的建立[J].医学信息,2022,35(10):165-167.[doi:10.3969/j.issn.1006-1959.2022.10.042]
　WANG Qiong,LI Shuai.Establishment of Reference Intervals for Anticardiolipin Antibody and Anti-β2 Glycoprotein Ⅰ Antibody in Healthy Women in Zhejiang Province[J].Medical Information,2022,35(10):165-167.[doi:10.3969/j.issn.1006-1959.2022.10.042]
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浙江地区健康女性抗心磷脂抗体和抗β2糖蛋白Ⅰ抗体参考区间的建立()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
165-167
栏目:
诊疗技术
出版日期:
2022-05-15

文章信息/Info

Title:
Establishment of Reference Intervals for Anticardiolipin Antibody and Anti-β2 Glycoprotein Ⅰ Antibody in Healthy Women in Zhejiang Province
文章编号:
1006-1959（2022）10-0165-03
作者:
王 琼; 李 帅
（浙江大学医学院附属妇产科医院检验科，浙江 杭州 310003）
Author(s):
WANG Qiong; LI Shuai
(Department of Clinical Laboratory,Affiliated Obstetrics and Gynecology Hospital of Medical College of Zhejiang University,Hangzhou 310003,Zhejiang,China)
关键词:
抗心磷脂抗体; 抗β2糖蛋白Ⅰ抗体; 参考区间
Keywords:
Anticardiolipin; Anti-β2 glycoprotein Ⅰ; Reference interval
分类号:
R446.6
DOI:
10.3969/j.issn.1006-1959.2022.10.042
文献标志码:
A
摘要:
目的 建立浙江地区健康女性抗心磷脂抗体（aCL）和抗β2糖蛋白Ⅰ抗体（anti-β2GPⅠ）参考区间。方法 选取2020年1月-2021年5月在浙江大学医学院附属妇产科医院体检的健康妇女225例，检测患者血清aCL IgM/IgG和anti-β2GPⅠIgM/IgG水平。结果 健康妇女aCL IgM/IgG和anti-β2GPⅠIgM/IgG数据均呈偏态分布；＜30岁组与≥30岁组aCL IgM/IgG和anti-β2GPⅠIgM/IgG水平分别比较，差异无统计学意义（P＞0.05）；浙江地区健康妇女aCL IgM/IgG和anti-β2GPⅠIgM/IgG参考区间的P95分别为：6.04 PL-U/ml、3.44 PL-U/ml、25.57 RU/ml和6.47 RU/ml；P99分别为：12.67 PL-U/ml、5.75 PL-U/ml、36.86 RU/ml和8.44 RU/ml。结论 年龄不作为aCL IgM/IgG和anti-β2GPⅠIgM/IgG水平参考区间的分组因素。本研究初步建立了浙江地区健康妇女aCL IgM/IgG和anti-β2GPⅠIgM/IgG的参考区间，这对于APS，尤其是非典型OAPS的诊断具有重要意义。
Abstract:
Objective To establish the reference intervals for anticardiolipin antibody and anti-β2 glycoprotein Ⅰ of healthy women in Zhejiang province.Methods From January 2020 to May 2021, 225 healthy women were selected as the participants at the Affiliated Obstetrics and Gynecology Hospital of Medical College of Zhejiang University. The levels of aCL IgM/IgG and anti-β2GPⅠ IgM/IgG were measured for all the participants.Results The data of aCL IgM/IgG and anti-β2GPⅠ IgM/IgG in healthy women showed a skewed distribution. There was no significant difference in the levels of aCL IgM/IgG and anti-β2GPⅠ IgM/IgG between <30 years old group and ≥30 years old group (P>0.05). The P95 of aCL IgM/IgG and anti-β2GPⅠ IgM/IgG levels in healthy women in Zhejiang province were: 6.04 PL-U/ml, 3.44 PL-U/ml, 25.57 RU/ml, and 6.47 RU/ml, respectively. The P99 of aCL IgM/IgG and anti-β2GPⅠ IgM/IgG levels in healthy women in Zhejiang province were: 12.67 PL-U/ml, 5.75 PL-U/ml, 36.86 RU/ml, and 8.44 RU/ml, respectively.Conclusion Age is not used as a grouping factor in the reference interval. In this study, the reference intervals for aCL IgM/IgG and anti-β2GPⅠ IgM/IgG of healthy women in Zhejiang province are preliminarily established, which is of great value for the diagnosis of APS, especially atypical OAPS.

参考文献/References:

[1]何国才,罗兆芹,白清,等.孕产妇抗磷脂抗体水平检测及其临床意义[J].检验医学与临床,2019,16(14):2044-2046.[2]张蜀澜,吴子燕,张文,等.抗磷脂综合征病态妊娠患者中抗磷脂抗体谱的临床意义[J].中华临床实验室管理电子杂志,2017,5(4):226-231.[3]陈晓辉,崔丽艳.抗磷脂抗体谱与病理妊娠[J].中华检验医学杂志,2018,41(12):922-927.[4]H?觟gdén A,Antovic A,Berg E,et al.Obstetric outcomes in patients with primary thrombotic and obstetric antiphospholipid syndrome and its relation to the antiphospholipid antibody profile[J].Lupus,2019,28(7):868-877.[5]Qi M,Weaver JC,Krilis SA,et al.Quantitation of total and free thiol β2 -glycoprotein i levels for diagnostic and prognostic purposes in the antiphospholipid syndrome[J].Methods Mol Biol,2019,1967:275-283.[6]中华医学会围产医学分会.产科抗磷脂综合征诊断与处理专家共识[J].中华围产医学杂志,2020,23(8):517-522.[7]陆姿赢,王晓栋,严金,等.以静脉血栓为主要表现的抗磷脂综合征2例[J].浙江医学,2018,40(5):500-501.[8]董瑶佳,吴冰,郭卉.抗心磷脂抗体与习惯性流产的关系[J].实验与检验医学,2017,35(6):924-925.[9]Liu T,Gu J,Wan L,et al."Non-criteria" antiphospholipid antibodies add value to antiphospholipid syndrome diagnoses in a large Chinese cohort[J].Arthritis research & therapy,2020,22(1):33.[10]陈玉阁.抗心磷脂抗体及抗β2糖蛋白抗体与自然流产的相关性研究[J].中国优生与遗传杂志,2017,25(6):71-72,112.[11]郭晗,乔蕊.抗磷脂综合征实验室检查项目的结果解读[J].临床检验杂志,2019,37(9):652-656.[12]李明英,王仁军,张帆,等.β2糖蛋白Ⅰ第五结构域及其突变体、短肽片段的原核表达及活性分析[J].中国生物工程杂志,2018,38(8):1-9.[13]周建伟,孔翠,蔡淑静,等.抗核抗体和抗心磷脂抗体在梅毒患者的检测及临床意义[J].中国中西医结合皮肤性病学杂志,2018,17(4):317-319.[14]吴晓怡,董海展,李建海.甲苯胺红不加热血清试验阳性与自身免疫性疾病的相关性研究[J].中国性科学,2016,25(2):63-65.[15]Miyakis S,Lockshin MD,Atsumi T,et al.International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)[J].J Thromb Haemost,2006,4(2):295-306.[16]徐佩,张静峥,朱淼,等.抗磷脂综合征患者妊娠期间抗磷脂抗体水平测定的意义[J].临床血液学杂志,2017,30(3):202-205.[17]中国医师协会风湿免疫科医师分会自身抗体检测专业委员会,国家风湿病数据中心,国家免疫疾病临床医学研究中心.抗磷脂抗体检测的临床应用专家共识[J].中华内科杂志,2019,58(7):496-500.[18]赵伟,刘庆平.β2-糖蛋白Ⅰ及其抗体复合物在APS发生发展及临床诊断治疗中的作用[J].中国生物化学与分子生物学报,2019,35(9):923-930.[19]王斌,黄劲,唐宁,等.554例抗磷脂抗体阳性病例的临床分析[J].国际检验医学杂志,2017,38(22):3185-3187.

更新日期/Last Update: 1900-01-01