[1]邹光美,黄朝任.白介素6基因多态性与多种疾病的相关性研究[J].医学信息,2022,35(12):61-64.[doi:10.3969/j.issn.1006-1959.2022.12.014]
 ZOU Guang-mei,HUANG Chao-ren.Correlation Between Interleukin 6 Gene Polymorphism and Various Diseases[J].Medical Information,2022,35(12):61-64.[doi:10.3969/j.issn.1006-1959.2022.12.014]
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白介素6基因多态性与多种疾病的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年12期
页码:
61-64
栏目:
综述
出版日期:
2022-06-15

文章信息/Info

Title:
Correlation Between Interleukin 6 Gene Polymorphism and Various Diseases
文章编号:
1006-1959(2022)12-0061-04
作者:
邹光美黄朝任
(1.玉林市第一人民医院检验科,广西 玉林 537000;2.玉林市中医医院检验科,广西 玉林 537000)
Author(s):
ZOU Guang-meiHUANG Chao-ren
(1.Department of Clinical Laboratory,the First People’s Hospital of Yulin 537000,Yulin,Guangxi,China;2.Department of Clinical Laboratory,Yulin Traditional Chinese Medicine Hospital,Yulin 537000,Guangxi,China)
关键词:
白介素6基因多态性心脑血管病血栓肝病风湿免疫病
Keywords:
Interleukin-6Gene polymorphismCardiovascular and cerebrovascular diseasesThrombosisLiver diseaseRheumatic immune disease
分类号:
R364.5
DOI:
10.3969/j.issn.1006-1959.2022.12.014
文献标志码:
A
摘要:
白细胞介素6(IL-6)是一种多效细胞因子,不仅具有免疫学作用,而且还具有造血、骨骼代谢和组织再生等功能。炎性细胞因子IL-6基因多态性可通过影响机体自身和其他细胞因子的转录和表达,在临床多种疾病中发挥重要的影响作用。因此,IL-6基因多态性研究成为心脑血管、血栓、肝病、风湿免疫、癌症等多种疾病的研究热点。本文对IL-6的基因多态性与多种疾病相关性的研究进展进行综述,以期为临床治疗相关疾病提供理论依据。
Abstract:
Interleukin-6 (IL-6) is a multi-effect cytokine, which not only has immunological function, but also has hematopoietic, bone metabolism and tissue regeneration functions. IL-6 gene polymorphism of inflammatory cytokines can play an important role in clinical diseases by affecting the transcription and expression of the body itself and other cytokines. Therefore, the study of IL-6 gene polymorphism has become a research hotspot in cardiovascular and cerebrovascular diseases, thrombosis, liver diseases, rheumatic immunity, cancer and other diseases. This paper reviews the research progress on the correlation between IL-6 gene polymorphism and various diseases, in order to provide theoretical basis for clinical treatment of related diseases.

参考文献/References:

[1]Georges JL,Loukaci V,Poirier O,et al.Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction:the ECTIM study. Etude Cas-Temoin de l’Infarctus du Myocarde[J].Journal of Molecular Medicine,2001,79(5-6):300-305.[2]Fajar JK,Azharuddin A.The association between interleukin 6 -174 G/C gene polymorphism and the risk of osteoporosis:A meta-analysis[J].Journal of Taibah University Medical Sciences,2016,12(3):212-220.[3]Xu Y,Zhang Y,Ye J.IL-6: A Potential Role in Cardiac Metabolic Homeostasis[J].International Journal of Molecular Sciences,2018,19(9):2474.[4]An PP,Feng LN,Zhang XX,et al.Association of interleukin-6 gene polymorphisms with the risk of hepatocellular carcinoma: An up-to-date meta-analysis[J].Medicine (Baltimore),2020,99(50):e23659.[5]Duan HX,Chen YY,Shi JZ,et al.Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility[J].Bioscience Reports,2018,38(5):BSR20181071.[6]González-Castro TB,Hernández-Díaz Y,Pérez-Hernández N,et al.Interleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseases:a meta-analysis of 74 studies with 86,229 subjects[J].EXCLI Journal,2019,18:331-355.[7]Yuepeng J,Zhao X,Zhao Y,et al.Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease: A meta-analysis[J].Medicine (Baltimore),2019,98(2):e13813.[8]Zheng GH,Chen HY,Xiong SQ.Polymorphisms of -174G>C and -572G>C in the interleukin 6 (IL-6) gene and coronary heart disease risk: a meta-analysis of 27 research studies[J].PLoS One,2012,7(4):e34839.[9]Zhang H,Liu C,Zhao B,et al.An Evidence-Based Meta-Analysis on the Roles of Functional Interleukin-6 Polymorphisms in Coronary Artery Disease[J].J Interferon Cytokine Res,2018,38(9):370-377.[10]Salari N,Mansouri K,Hosseinian-Far A,et al.The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis[J].Genes Environ,2021,43(1):1.[11]Lu S,Wang Y,Wang Y,et al.The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk[J].J Cell Mol Med,2020,24(11):6191-6207.[12]Akhter MS,Biswas A,Abdullah SM,et al.Influence of Interleukin-6(IL-6) Promoter Gene Polymorphisms(-174G>C,-572G>C,and-597G>A)on IL-6 Plasma Levels and Their Impact in the Development of Acute Ischemic Stroke in Young Indians[J].Clin Appl Thromb Hemost,2019,25:1076029619854136.[13]Ren H,Zhang Y,Yao Y,et al.Association between the interleukin-6 genetic polymorphism 174?G/C and thrombosis disorder risk:Meta-analysis of 10,549 cases and 19,316 controls[J].Medicine (Baltimore),2016,95(27):e4030.[14]Unal S,Gumruk F,Aytac S,et al.Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) levels and IL-6, TNF-polymorphisms in children with thrombosis[J].J Pediatr Hematol Oncol,2008,30(1):26-31.[15]Kim SK,Chung JH,Kwon OY.Promoter Polymorphism (?174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis. Medical Science Monitor:International Medical Journal of Experimental and Clinical Research[J].Med Sci Monit,2016,22:4345-4353.[16]Wang X,Yan Z,Ye Q.Interleukin-6 gene polymorphisms and susceptibility to liver diseases:A meta-analysis[J].Medicine (Baltimore),2019,98(50):e18408.[17]Jalali R,Vaisi-Raygani A,Zhu J.Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility:An Updated Meta-Analysis of 21 Case-Control Studies[J].Dis Markers,2016,2016: 9612421.[18]Chatzopoulos GS,Doufexi AE,Kouvatsi A.Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms. Scientific Reports[J].Med Oral Patol Oral Cir Bucal,2017,22(4):e446-e457.[19]刘满想,宋春峰,张宝营,等.IL-6–174C/G基因多态性与胃癌易感性的meta分析[J].中国普外基础与临床杂志,2017,24(10):1234-1245.[20]Salman BN,Vahabi S,Biglari A,et al.Correlation of interleukin-6-174 GC and interleukin-6-572 GC gene polymorphisms with periodontal disease in an Iranian population[J].Dental Research Journal,2016,13(4):354-361.[21]温鹏飞,王晓松,张敏,等.IL-6基因单核苷酸多态性与系统性红斑狼疮的相关性研究[J].中华疾病控制杂志,2014,18(4):277-280.[22]Ruiz-Padilla AJ,Gamez-Nava JI,Salda?觡a-Cruz AM,et al.The -174G/C Interleukin-6 Gene Promoter Polymorphism as a Genetic Marker of Differences in Therapeutic Response to Methotrexate and Leflunomide in Rheumatoid Arthritis[J].Biomed Res Int,2016,2016:4193538. [23]Zhai K,Yang Y,Gao ZG,et al.Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer[J].Oncotarget,2017,8(27):44490-44497.[24]Wang Y,Chen X,Chen Y.Interleukin-6 gene -572G/C polymorphism and prostate cancer risk[J].African Health Sciences,2018,18(2):267-272.[25]Zhao Q,Jin M,Zhang DW,et al.Serum Interleukin-6 Level and the rs1800795 Polymorphism in its Gene Associated with Neuroblastoma Risk in Chinese Children[J].J Cell Mol Med,2018,131(9):1075-1078.[26]Rezaei F,Mohammadi H,Heydari M,et al.Association betweenIL-8 (-251T/A)andIL-6 (-174G/C)Polymorphisms and Oral Cancer Susceptibility: A SystematicReview and Meta-Analysis[J].Medicina (Kaunas),2021,57(5):405.[27]Aleagha OE,Oltulu P,Sadeghi M.Association between interleukin 6 polymorphisms (rs1800796,rs1800795,rs2069837, rs17147230,and rs1800797) and hepatocellular carcinoma susceptibility:a meta-analysis[J].Clinical and Experimental Hepatology,2020,6(4):359-366.[28]Zhao X,Jiang Y,Ping Y,et al.Associations between tumor necrosis factor-α and interleukin-6 polymorphisms and unexplained recurrent spontaneous abortion risk: A meta-analysis[J].Medicine (Baltimore),2019,98(46):e17919.[29]Chen L,Zhang Z,Huang J,et al.Association between rs1800795 polymorphism in the interleukin-6 gene and the risk of polycystic ovary syndrome:A meta-analysis[J].Medicine (Baltimore),2018,97(29):e11558.[30]Lorente L,Martín MM,Pérez-Cejas A,et al.Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients[J].International Journal of Molecular Sciences,2016,17(11):1861.

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更新日期/Last Update: 1900-01-01