[1]何 浓,张永胜,熊福生,等.老年骨质疏松症全髋关节置换后假体无菌性松动的药物防治研究[J].医学信息,2022,35(12):77-80,88.[doi:10.3969/j.issn.1006-1959.2022.12.018]
 HE Nong,ZHANG Yong-sheng,XIONG Fu-sheng,et al.Study on Drug Prevention and Treatment of Aseptic Loosening of Prosthesis After Total Hip Arthroplasty in Senile Osteoporosis[J].Medical Information,2022,35(12):77-80,88.[doi:10.3969/j.issn.1006-1959.2022.12.018]
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老年骨质疏松症全髋关节置换后假体无菌性松动的药物防治研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年12期
页码:
77-80,88
栏目:
综述
出版日期:
2022-06-15

文章信息/Info

Title:
Study on Drug Prevention and Treatment of Aseptic Loosening of Prosthesis After Total Hip Arthroplasty in Senile Osteoporosis
文章编号:
1006-1959(2022)12-0077-05
作者:
何 浓张永胜熊福生
(川北医学院附属遂宁市中医院骨科,四川 遂宁 629000)
Author(s):
HE NongZHANG Yong-shengXIONG Fu-shenget al.
(Department of Orthopedics,Suining Municipal Hospital of TCM Affiliated to North Sichuan Medical College,Suining 629000,Sichuan,China)
关键词:
老年骨质疏松症全髋关节置换假体无菌性松动
Keywords:
Senile osteoporosisHip arthroplastyAseptic loosening of prosthesis
分类号:
R87.4
DOI:
10.3969/j.issn.1006-1959.2022.12.018
文献标志码:
A
摘要:
全髋关节置换术是晚期及重度髋关节疾病的有效治疗方法。当前,由于生物材料自身缺陷和人体生物力学等因素影响,并不能保证所有患者术后可以终身正常使用,而髋关节假体无菌性松动则是全髋关节置换术后常见的晚期并发症。老龄化不可避免的会导致骨质疏松,进一步加速假体的松动。本文主要对老年骨质疏松症全髋关节置换后假体无菌性松动的潜在药物防治进展做一综述,以期为后续临床研究提供参考。
Abstract:
Total hip arthroplasty is an effective treatment for advanced and severe hip diseases. At present, due to the defects of biological materials and human biomechanics and other factors, it cannot ensure that all patients can be used normally for life after surgery, and aseptic loosening of hip prosthesis is a common late complication after total hip arthroplasty. Aging inevitably leads to osteoporosis and further accelerates prosthesis loosening. This article mainly reviews the potential drug prevention and treatment progress of aseptic loosening of prosthesis after total hip arthroplasty in elderly osteoporosis, in order to provide reference for subsequent clinical research.

参考文献/References:

[1]中华人民共和国国家统计局.中国统计年鉴[M].北京:中国统计出版,2020.[2]国家卫生健康委员会.国家卫生健康委员会2018年10月19日媒体沟通会文字实录[EB/OL].http://www.nhc.gov.cn/wjw/xwdt/201810/d816a5c72f6b45e399a1e7214642cd47.shtml, 2018-10-19/2021-11-10.[3]Liu J,Curtis EM,Cooper C,et al.State of the art in osteoporosis risk assessment and treatment[J].J Endocrinol Invest,2019,42(10):1149-1164.[4]边焱焱,程开源,常晓,等.2011至2019年中国人工髋膝关节置换手术量的初步统计与分析[J].中华骨科杂志,2020,(21):1453-1460.[5]顾建明,冯啸,周一新.1422例人工髋关节翻修术病因分析[J].中华骨与关节外科杂志,2021,14(4):267-271.[6]Dunet V,Bernasconi M,Hajdu SD,et al.Impact of metal artifact reduction software on image quality of gemstone spectral imaging dual-energy cerebral CT angiography after intracranial aneurysm clipping[J].Neuroradiology,2017,59(9):845-852.[7]唐专科,柯宝毅,肖念苏,等.X线、CT及MRI对髋关节置换术后并发症诊断的临床价值[J].中国CT和MRI杂志,2021,(2):147-148,158.[8]王晨华,刘勇,李燕,等.骨显像对关节置换术后假体无菌性松动与假体周围感染的诊断价值[J].医学影像学杂志,2019,(5):836-839.[9]Pinski JM,Chen AF,Estok DM,et al.Nuclear Medicine Scans in Total Joint Replacement[J].J Bone Joint Surg Am,2021,103(4):359-372.[10]张炅,刘志宏,何川,等.髋关节置换术后中长期随访无症状患者~(99m)Tc三相同位素骨扫描结果分析[J].生物骨科材料与临床研究,2018(1):30-34,37.[11]李原,李虎,王茜,等.三时相骨显像诊断人工关节假体周围感染[J].中国医学影像技术,2020(10):1527-1532.[12]梁鹏,牛舜.人工关节置换术后假体无菌性松动的早期诊断[J].中华关节外科杂志(电子版),2019(1):99-104.[13]Tella SH,Gallagher JC.Prevention and treatment of postmenopausal osteoporosis [J].J Steroid Biochem Mol Biol,2014,142:155-170.[14]Hu B,Wu H,Shi Z,et al.Effects of sequential treatment with intermittent parathyroid hormone and zoledronic acid on particle-induced implant loosening: Evidence from a rat model[J].J Orthop Res,2019,37(7):1489-1497.[15]Brandt J,Ledin H,Ranstam J,et al.Single postoperative infusion of zoledronic acid to improve patient-reported outcome after hip or knee replacement: study protocol for a randomised, controlled, double-blinded clinical trial[J].BMJ Open,2020,10(9):e040985.[16]Wang P,Shang GQ,Xiang S,et al.Zoledronic acid and teriparatide have a complementary therapeutic effect on aseptic loosening in a rabbit model[J].BMC Musculoskelet Disord,2021,22(1):580.[17]黄飞麒,赵晓,姚乃捷,等.老年骨质疏松症患者全髋关节置换后应用阿仑膦酸钠维D3[J].中国组织工程研究,2017,21(15):2303-2307.[18]王宇胜,陈顺贤,朱春城.养血固肾汤联合阿仑膦酸钠维D3治疗绝经后骨质疏松症30例观察[J].浙江中医杂志,2020,55(3):211-212.[19]中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中国骨质疏松杂志,2019,25(3):281-309.[20]冷屹,胡懿郃,曾敏,等.鲑鱼降钙素对磨损颗粒诱导后人巨噬细胞RANK/RANKL/OPG骨溶解通路的影响[J].中国医师杂志,2019,21(1):64-68.[21]贾丙申,焦拓,纪志华,等.当归续断汤联合鲑鱼降钙素喷鼻剂防治老年人工全髋关节置换术后假体无菌性松动的疗效及对骨代谢及炎症反应的影响[J].现代中西医结合杂志,2021,30(4):384-388.[22]李旻,王娜,蒋雨宸,等.老年股骨颈骨折人工股骨头置换术后迈之灵片和鲑鱼降钙素联合应用的临床疗效[J].中国综合临床,2021,37(2):154-160.[23]Food and Drug Administration.Queations and answers:Changes to the indicated population for miacalcin (calcitonin-salmon) [EB/OL].https://www.fda.go-v/drugs/drugsafety/postmarketdrugsafetyinformationforpatient sandproviders/ucm38-8641.htm,2013-03-11/2021-11-10.[24]朱汉民,廖二元.鲑鱼降钙素专家讨论会纪实[J].中华骨质疏松和骨矿盐疾病杂志,2013,6(4):370-372.[25]Geng T,Sun S,Yu H,et al.Strontium ranelate inhibits wear particle-induced aseptic loosening in mice[J].Braz J Med Biol Res,2018,51(9):e7414.[26]Geng T,Sun S,Chen X,et al.Strontium ranelate reduces the progression of titanium particle-induced osteolysis by increasing the ratio of osteoprotegerin to receptor activator of nuclear factor-κB ligand in vivo[J].Mol Med Rep,2018,17(3):3829-3836.[27]Geng T,Chen X,Zheng M,et al.Effects of strontium ranelate on wear particle-induced aseptic loosening in female ovariectomized mice[J].Mol Med Rep,2018,18(2):1849-1857.[28]Nystr?觟m A,Kiritopoulos D,Ullmark G,et al.Denosumab Prevents Early Periprosthetic Bone Loss After Uncemented Total Hip Arthroplasty: Results from a Randomized Placebo-Controlled Clinical Trial[J].J Bone Miner Res,2020,35(2):239-247.[29]Zheng J,Brion MJ,Kemp JP,et al.The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study[J].J Bone Miner Res,2020,35(7):1224-1235.[30]Hong W,Wei Z,Qiu Z,et al.Atorvastatin promotes bone formation in aged apoE-/- mice through the Sirt1-Runx2 axis[J].J Orthop Surg Res,2020,15(1):303.[31]Jwa CS,Yi HJ,Oh SJ,et al.Prior use of 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase inhibitor, simvastatin fails to improve outcome after experimental intracerebral hemorrhage[J].J Korean Neurosurg Soc,2011,50(5):403-408.[32]Zhang Z,Dai F,Cheng P,et al.Pitavastatin attenuates monocyte activation in response to orthopedic implant-derived wear particles by suppressing the NF-κB signaling pathway[J].Mol Med Rep,2015,12(5):6932-6938.[33]Zhang X,Sun Y,Xie H,et al.The effect of simvastatin on periprosthetic bone mineral density in the hypercholesterolaemic patients after total hip arthroplasty[J].Int Orthop,2018,42(1):59-64.[34]Alotaibi HF,Perni S,Prokopovich P.Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention[J].Int J Nanomedicine,2019,14:7309-7322.[35]Rivera MC,Perni S,Sloan A,et al.Anti-inflammatory drug-eluting implant model system to prevent wear particle-induced periprosthetic osteolysis[J].Int J Nanomedicine,2019,14:1069-1084.[36]蔡成,何光亮.仙灵骨葆胶囊对绝经后骨质疏松症伴肥胖症患者脂质代谢、骨代谢及骨密度的影响[J].河南医学高等专科学校学报,2021,33(1):27-31.[37]姚洁,欧国峰,董博,等.抗疏强骨合剂结合基础抗骨质疏松药物治疗原发性骨质疏松症的疗效分析[J].中国骨质疏松杂志,2020,26(1):79-84.[38]Moran MM,Wilson BM,Li J,et al.The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats[J].FASEB J,2020,34(11):14302-14317.[39]Wang Z,Xue K,Bai M,et al.Probiotics protect mice from CoCrMo particles-induced osteolysis[J].Int J Nanomedicine,2017,12:5387-5397.[40]Li D,Wang H,Li Z,et al.The inhibition of RANKL expression in fibroblasts attenuate CoCr particles induced aseptic prosthesis loosening via the MyD88-independent TLR signaling pathway[J].Biochem Biophys Res Commun,2018,503(2):1115-1122.[41]Tian Y,Terkawi MA,Onodera T,et al.Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles[J].Front Immunol,2020,11:1720.[42]Xiao L,Xiao Y.The Autophagy in Osteoimmonology: Self-Eating,Maintenance,and Beyond[J].Front Endocrinol (Lausanne),2019,10:490.[43]Ruolan W,Liangjiao C,Longquan S.The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles[J].J Nanobiotechnology,2020,18(1):119.

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更新日期/Last Update: 1900-01-01