[1]王艳霞.中药灌肠对尿毒症血液透析患者便秘、食欲减退及呕吐等不良反应的影响[J].医学信息,2022,35(17):88-90,94.[doi:10.3969/j.issn.1006-1959.2022.17.023]
　WANG Yan-xia.Effect of Traditional Chinese Herb Enema on Adverse Reactions of Constipation,Loss of Appetite and Vomiting in Uremic Hemodialysis Patients[J].Journal of Medical Information,2022,35(17):88-90,94.[doi:10.3969/j.issn.1006-1959.2022.17.023]
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中药灌肠对尿毒症血液透析患者便秘、食欲减退及呕吐等不良反应的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年17期
页码:
88-90,94
栏目:
论著
出版日期:
2022-09-01

文章信息/Info

Title:
Effect of Traditional Chinese Herb Enema on Adverse Reactions of Constipation,Loss of Appetite and Vomiting in Uremic Hemodialysis Patients
文章编号:
1006-1959（2022）17-0088-04
作者:
王艳霞
（天津市北辰区中医医院血透科，天津 300400）
Author(s):
WANG Yan-xia
(Department of Hemodialysis,Beichen District Hospital of Traditional Chinese Medicine,Tianjin 300400,China)
关键词:
尿毒症; 血液透析; 中药灌肠; 便秘; 食欲减退; 呕吐
Keywords:
Uremia; Hemodialysis; Traditional Chinese medicine enema; Constipation; Loss of appetite; Vomiting
分类号:
R692.5
DOI:
10.3969/j.issn.1006-1959.2022.17.023
文献标志码:
A
摘要:
目的 研究中药灌肠对尿毒症血液透析患者便秘、食欲减退及呕吐等不良反应的影响。方法 选取2019年6月-2021年6月于天津市北辰区中医医院接受血液透析治疗的80例尿毒症患者，按照随机数字表法分为对照组和观察组，各40例。对照组行常规血液透析治疗，观察组采用中药灌肠联合血液透析治疗，比较两组临床疗效、血清生化指标[血肌酐（SCr）、尿素氮（BUN）、内生肌酐清除率（CCr）]、透析充分性[蛋白分解率（PCR）、尿素清除指数Kt/V值、平均尿素氮浓度（TACurea）]、氧化应激指标[血浆丙二醛（P-MDA）、超氧化物歧化酶（P-SOD）、过氧化氢酶（P-CAT）]、不良反应发生情况（便秘、食欲减退、呕吐）。结果 观察组治疗有效率高于对照组，差异有统计学意义（P＜0.05）；两组治疗后SCr、BUN水平下降，CCr水平升高，且观察组SCr、BUN水平低于对照组，CCr水平高于对照组，差异有统计学意义（P＜0.05）；观察组PCR、TACurea低于对照组，Kt/V值高于对照组，差异有统计学意义（P＜0.05）；对照组治疗后P-MDA高于治疗前及观察组，P-SOD、P-CAT低于治疗前及观察组，差异有统计学意义（P＜0.05）；观察组治疗前后P-MDA、P-SOD、P-CAT水平比较，差异无统计学意义（P＞0.05）；观察组便秘、食欲减退、呕吐发生率低于对照组，差异有统计学意义（P＜0.05）。结论 中药灌肠可增强血液透析效果，保证血透充分性，同时抑制氧化应激反应亢进，降低便秘、食欲减退及呕吐等不良反应的发生风险。
Abstract:
Objective To study the effect of traditional Chinese medicine enema on adverse reactions such as constipation, loss of appetite and vomiting in uremic hemodialysis patients.Methods A total of 80 patients with uremia who received hemodialysis in Tianjin Beichen District Hospital of Traditional Chinese Medicine from June 2019 to June 2021 were selected and divided into control group and observation group according to the random number table method, with 40 cases in each group. The control group was treated with routine hemodialysis, and the observation group was treated with traditional Chinese medicine enema combined with hemodialysis. The clinical efficacy, serum biochemical indexes [serum creatinine (SCr), urea nitrogen (BUN), endogenous creatinine clearance rate (CCr)], dialysis adequacy [protein decomposition rate (PCR), urea clearance index Kt/V value, average urea nitrogen concentration (TACurea)], oxidative stress indexes [plasma malondialdehyde (P-MDA), superoxide dismutase (P-SOD), catalase (P-CAT) ], adverse reactions (constipation, loss of appetite, vomiting) were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of SCr and BUN in the two groups decreased, and the level of CCr increased,while the levels of SCr and BUN in the observation group were lower than those in the control group, and the level of CCr was higher than that in the control group,the difference was statistically significant (P<0.05). The PCR and TACurea in the observation group were lower than those in the control group, and the Kt/V value was higher than that in the control group, and the difference was statistically significant (P<0.05). After treatment, P-MDA in the control group was higher than that before treatment and in the observation group, P-SOD and P-CAT were lower than those before treatment and in the observation group, and the differences were statistically significant (P<0.05). There was no significant difference in the levels of P-MDA, P-SOD and P-CAT before and after treatment in the observation group (P>0.05). The incidence of constipation, loss of appetite and vomiting in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion Traditional Chinese medicine enema can enhance the effect of hemodialysis, ensure the adequacy of hemodialysis, inhibit the hyperactivity of oxidative stress, and reduce the risk of adverse reactions such as constipation, loss of appetite and vomiting.

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更新日期/Last Update: 1900-01-01