[1]魏丽丽,郝瑞卿,王华瑛.KPNA2在乳腺癌组织中的表达及临床病理意义[J].医学信息,2022,35(18):53-56.[doi:10.3969/j.issn.1006-1959.2022.18.012]
　WEI Li-li,HAO Rui-qing,WANG Hua-ying.The Expressions of KPNA2 in the Breast Cancer and its Clinicopathological Significance[J].Journal of Medical Information,2022,35(18):53-56.[doi:10.3969/j.issn.1006-1959.2022.18.012]
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KPNA2在乳腺癌组织中的表达及临床病理意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年18期
页码:
53-56
栏目:
论著
出版日期:
2022-09-15

文章信息/Info

Title:
The Expressions of KPNA2 in the Breast Cancer and its Clinicopathological Significance
文章编号:
1006-1959（2022）18-0053-04
作者:
魏丽丽; 郝瑞卿; 王华瑛
（昌邑市妇幼保健院病理科1，儿科2，妇科3，山东 昌邑 261300）
Author(s):
WEI Li-li; HAO Rui-qing; WANG Hua-ying
(Department of Pathology1,Department of Pediatrics2,Department of Gynecology3,Changyi Maternal and Child Care Hospital,Changyi 261300,Shandong,China)
关键词:
乳腺癌; 临床病理参数; KPNA2; β-catenin; cyclinD1
Keywords:
Breast cancer; Clinicopathological parameter; KPNA2; β-catenin; cyclinD1
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2022.18.012
文献标志码:
A
摘要:
目的 探讨KPNA2、β-catenin及cyclinD1在乳腺癌中的表达及临床病理意义。方法 选取我院2014年1月-2019年8月未经放化疗的乳腺浸润性导管癌标本120例设为实验组，另选取50例实验组的距离癌旁1 cm的正常乳腺组织作为对照组。采用免疫组化方法检测组织中KPNA2、β-catenin及cyclinD1的表达情况，分析KPNA2、β-catenin及cyclinD1与乳腺癌临床病理参数及预后的关系。结果 KPNA2、β-catenin、CyclinD1在乳腺癌中高表达率分别为53.30%、49.10%、50.80%，呈明显高表达（P＜0.05）；KPNA2、β-catenin及cyclinD1的表达与组织学级别、淋巴结转移、TNM分期、Ki-67指数相关（P＜0.05），与ER、PR、HER-2的表达、肿瘤大小及年龄无关（P＞0.05）；KPNA2的表达分别与β-catenin（r=0.350，P=0.010）、cyclinD1（r=0.370，P=0.010）呈正相关，β-catenin的表达与cyclinD1的表达呈正相关（r=0.320，P=0.030）；通过TCGA数据库得知，KPNA2高表达乳腺癌患者预后不良。结论 KPNA2、β-catenin及cyclinD1的表达与乳腺癌的恶性程度、高侵袭性及增殖指数高有关。KPNA2高表达提示乳腺癌患者预后不良，可能用于临床预后指导，其作用于乳腺癌的发生发展机制可能与Wnt通路相关。
Abstract:
Objective To investigate the expression and clinicopathological significance of KPNA2, β-catenin and cyclinD1 in breast cancer.Methods A total of 120 cases of breast invasive ductal carcinoma without radiotherapy and chemotherapy in our hospital from January 2014 to August 2019 were selected as the experimental group, and 50 cases of normal breast tissue 1 cm away from the paracancerous tissue were selected as the control group. The expression of KPNA2, β-catenin and cyclinD1 was detected by immunohistochemistry. The relationship between the expression of KPNA2, β-catenin, cyclinD1 and clinicopathological parameters and prognosis of breast cancer was analyzed.Results The high expression rates of KPNA2, β-catenin and CyclinD1 in breast cancer were 53.30%, 49.10% and 50.80%, respectively, which were significantly higher (P<0.05). The expression of KPNA2, β-catenin and cyclinD1 was correlated with histological grade, lymph node metastasis, TNM stage and Ki-67 index (P<0.05), but not with ER, PR, HER-2 expression, tumor size and age (P>0.05). The expression of KPNA2 was positively correlated with β-catenin (r=0.350, P=0.010) and cyclinD1 (r=0.370, P=0.010); the expression of β-catenin was positively correlated with cyclinD1 (r=0.320, P=0.030). According to the TCGA database, breast cancer patients with high KPNA2 expression have a poor prognosis.Conclusion The expression of KPNA2, β-catenin and cyclinD1 is related to the malignant degree, high invasiveness and high proliferation index of breast cancer. The high expression of KPNA2 suggests that the prognosis of breast cancer patients is poor, which may be used for clinical prognosis guidance. The mechanism of its role in the occurrence and development of breast cancer may be related to the Wnt pathway.

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更新日期/Last Update: 1900-01-01