[1]黄双双,邹 会,杨 晖.自拟清热解毒方灌肠对血液透析患者微炎症状态的影响[J].医学信息,2022,35(18):124-127.[doi:10.3969/j.issn.1006-1959.2022.18.034]
　HUANG Shuang-shuang,ZOU Hui,YANG Hui.Effect of Self-made Qingre Jiedu Decoction for Enema on Micro-inflammatory State in Hemodialysis Patients[J].Journal of Medical Information,2022,35(18):124-127.[doi:10.3969/j.issn.1006-1959.2022.18.034]
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自拟清热解毒方灌肠对血液透析患者微炎症状态的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年18期
页码:
124-127
栏目:
中医中药
出版日期:
2022-09-15

文章信息/Info

Title:
Effect of Self-made Qingre Jiedu Decoction for Enema on Micro-inflammatory State in Hemodialysis Patients
文章编号:
1006-1959（2022）18-0124-04
作者:
黄双双; 邹 会; 杨 晖
（景德镇市中医医院内二科，江西 景德镇 333000）
Author(s):
HUANG Shuang-shuang; ZOU Hui; YANG Hui
(The Second Department of Internal Medicine,Jingdezhen Traditional Chinese Medicine Hospital, Jingdezhen 333000,Jiangxi,China)
关键词:
清热解毒方; 灌肠; 血液透析; 微炎症指标
Keywords:
Qingre Jiedu decoction; Enema; Hemodialysis; Micro-inflammatory state
分类号:
R277.5
DOI:
10.3969/j.issn.1006-1959.2022.18.034
文献标志码:
A
摘要:
目的 探究自拟清热解毒方灌肠对血液透析患者微炎症状态的影响。方法 选取2019年8月-2021年7月在我院接受血液透析治疗并出现微炎症状态的60例患者作为研究对象，随机分为观察组和对照组，每组30例。对照组给予血液透析，治疗组在对照组基础上给予自拟清热解毒方灌肠治疗。比较两组临床疗效、血清炎性因子[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）]、肝功能[C3、C4、谷草转氨酶（AST）、谷丙转氨酶（ALT）、血清总蛋白（TB）]、免疫功能（CD4+、CD8+、CD4+/CD8+）水平、生活质量和不良反应发生情况。结果 观察组治疗总有效率高于对照组（96.67% vs 73.33%），差异有统计学意义（P＜0.05）；观察组IL-6、TNF-α、CRP、AST、ALT、TB、CD4+、CD4+/CD8+水平均低于对照组，C3、C4、CD8+水平高于对照组，差异有统计学意义（P＜0.05）；观察组生理功能、心理功能、社会功能评分均高于对照组，差异有统计学意义（P＜0.05）；观察组不良反应总发生率低于对照组（6.67% vs 33.33%），差异有统计学意义（P＜0.05）。结论 清热解毒方灌肠可以改善血液透析出现微炎症状态患者炎性因子水平，肝功能、免疫功能及生活治疗，有益于患者的血液透析治疗。
Abstract:
Objective To explore the effect of self-made Qingre Jiedu decoction for enema on micro-inflammatory state in hemodialysis patients.Methods From August 2019 to July 2021,60 patients who received hemodialysis in our hospital and had microinflammatory state were selected as the research objects, and randomly divided into observation group and control group, with 30 cases in each group. The control group was given hemodialysis, and the treatment group was given self-made Qingre Jiedu decoction for enema on the basis of the control group. The clinical efficacy, serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP)], liver function [C3, C4, aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum total protein (TB)], immune function (CD4+, CD8+, CD4+/CD8+), quality of life and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group (96.67% vs 73.33%), and the difference was statistically significant (P<0.05). The levels of IL-6, TNF-α, CRP, AST, ALT, TB, CD4+ and CD4+/CD8+ in the observation group were lower than those in the control group, and the levels of C3, C4 and CD8+ were higher than those in the control group, the difference was statistically significant (P<0.05). The scores of physiological function, psychological function and social function in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (6.67% vs 33.33%), and the difference was statistically significant (P<0.05). Conclusion Self-made Qingre Jiedu decoction for enema can improve the level of inflammatory factors, liver function, immune function and life treatment of patients with micro-inflammation state on hemodialysis, which is beneficial to hemodialysis treatment of patients.

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更新日期/Last Update: 1900-01-01