[1]孙言非.血清同型半胱氨酸、N末端B型脑钠肽水平在预测心律失常中的价值[J].医学信息,2022,35(18):141-143.[doi:10.3969/j.issn.1006-1959.2022.18.039]
　SUN Yan-fei.The Value of Serum Homocysteine and N-terminal B-type Brain Natriuretic Peptide Levels in Predicting Arrhythmia[J].Journal of Medical Information,2022,35(18):141-143.[doi:10.3969/j.issn.1006-1959.2022.18.039]
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血清同型半胱氨酸、N末端B型脑钠肽水平在预测心律失常中的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年18期
页码:
141-143
栏目:
诊疗技术
出版日期:
2022-09-15

文章信息/Info

Title:
The Value of Serum Homocysteine and N-terminal B-type Brain Natriuretic Peptide Levels in Predicting Arrhythmia
文章编号:
1006-1959（2022）18-0141-03
作者:
孙言非
（佳木斯市中心医院检验科，黑龙江 佳木斯 154002）
Author(s):
SUN Yan-fei
(Department of Laboratory,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
心律失常; N末端B型脑钠肽; 同型半胱氨酸; 慢性心力衰竭
Keywords:
Arrhythmia; N terminal B type brain natriuretic peptide; Homocysteine; Chronic heart failure
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2022.18.039
文献标志码:
A
摘要:
目的 评价N末端B型脑钠肽、同型半胱氨酸与慢性心力衰竭患者发生心律失常的相关性，以及对患者发生心律失常的诊断价值。方法 收集2020年5月-2021年7月在我院治疗的慢性心力衰竭患者的临床资料，根据患者是否患有心力衰竭将患者分为非心律失常组49例和心律失常组33例，对照组为同期在体检科进行检查的40例健康者。比较心律失常组、非心律失常组与对照组N末端B型脑钠肽与同型半胱氨酸指标。采用多变量Logistics回归分析评价N末端B型脑钠肽、同型半胱氨酸与心律失常发病的相关性。采用受试者工作特征曲线分析同型半胱氨酸氨酸与N末端B型脑钠肽对于预测慢性心力衰竭患者发生心律失常的诊断价值。结果 心律失常组、非心律失常组同型半胱氨酸及N末端B型脑钠肽均高于对照组，差异有统计学意义（P＜0.05）；心律失常组同型半胱氨酸、N末端B型脑钠肽均高于非心律失常组，差异有统计学意义（P＜0.05）；N末端B型脑钠肽（95%CI：0.046~0.081，P＜0.05）与同型半胱氨酸（95%CI：0.003~0.005，P＜0.05）是患者发生心律失常的独立相关因素；N末端B型脑钠肽（AUC=0.924，95%CI：0.871~0.966，P＜0.05）、同型半胱氨酸氨酸（AUC=0.868，95%CI：0.786~0.941，P＜0.05）对于预测慢性心力衰竭患者发生心律失常具有较高的诊断价值。结论 同型半胱氨酸、N末端B型脑钠肽可用于临床预测慢性心力衰竭患者心律失常的发生。
Abstract:
Objective To evaluate the correlation between N-terminal B-type brain natriuretic peptide, homocysteine and arrhythmia in patients with chronic heart failure, and the diagnostic value of arrhythmia in patients.Methods The clinical data of patients with chronic heart failure who were treated in our hospital from May 2020 to July 2021 were collected. According to whether the patient had heart failure, the patients were divided into 49 cases of non-arrhythmia group and 33 cases of arrhythmia group. The control group was 40 healthy people who were examined in the physical examination department during the same period. The N-terminal B-type brain natriuretic peptide and homocysteine indexes of arrhythmia group, non-arrhythmia group and control group were compared. Multivariate Logistics regression analysis was used to evaluate the correlation between N-terminal B-type brain natriuretic peptide, homocysteine and arrhythmia. The diagnostic value of homocysteine and N-terminal B-type brain natriuretic peptide in predicting arrhythmia in patients with chronic heart failure was analyzed by receiver operating characteristic curve.Results Homocysteine and N-terminal B-type brain natriuretic peptide in arrhythmia group and non-arrhythmia group were higher than those in control group (P<0.05). Homocysteine and N-terminal B-type brain natriuretic peptide in arrhythmia group were higher than those in non-arrhythmia group, and the differences were statistically significant (P<0.05). N-terminal pro-brain natriuretic peptide (95%CI:0.046-0.081,P<0.05) and homocysteine (95%CI:0.003-0.005,P<0.05) were independent risk factors of arrhythmia. N-terminal B-type brain natriuretic peptide (AUC=0.924,95%CI:0.871-0.966,P<0.05 ) and homocysteine (AUC=0.868,95%CI:0.786-0.941,P<0.05) had high diagnostic value for predicting arrhythmia in patients with chronic heart failure.Conclusion Homocysteine and N-terminal B-type brain natriuretic peptide can be used to predict the occurrence of arrhythmia in patients with chronic heart failure.

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更新日期/Last Update: 1900-01-01