[1]裴艳莹.儿童单纯疱疹病毒性脑炎的临床特征和预后分析[J].医学信息,2022,35(21):92-94.[doi:10.3969/j.issn.1006-1959.2022.21.021]
 PEI Yan-ying.Analysis of Clinical Features and Prognosis of Herpes Simplex Encephalitis in Children[J].Journal of Medical Information,2022,35(21):92-94.[doi:10.3969/j.issn.1006-1959.2022.21.021]
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儿童单纯疱疹病毒性脑炎的临床特征和预后分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年21期
页码:
92-94
栏目:
论著
出版日期:
2022-11-01

文章信息/Info

Title:
Analysis of Clinical Features and Prognosis of Herpes Simplex Encephalitis in Children
文章编号:
1006-1959(2022)21-0092-03
作者:
裴艳莹
(佳木斯市中心医院儿科,黑龙江 佳木斯 154002)
Author(s):
PEI Yan-ying
(Department of Pediatrics,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
单纯疱疹病毒脑炎脑脊液特异性抗体头颅MRI
Keywords:
Herpes simplex virusEncephalitisCerebrospinal fluid specific antibodyBrain MRI
分类号:
R725.1
DOI:
10.3969/j.issn.1006-1959.2022.21.021
文献标志码:
A
摘要:
目的 探讨儿童单纯疱疹病毒性脑炎的临床特征和预后影响因素。方法 随机选取2018年6月-2021年9月在我院被诊断为儿童单纯疱疹病毒性脑炎患者共80例,按照症状程度分为轻症组和重症组,每组40例,比较两组临床表现、头颅MRI和脑脊液检查结果及预后随访脑损害情况。结果 两组均有不同程度的临床症状,其中轻症组发热、惊厥、癫痫少于重症组,差异有统计学意义(P<0.05);两组头痛和呕吐症状比较,差异无统计学意义(P>0.05);重症组头颅MRI信号显示异常和脑内出血的发生率高于轻症组,差异有统计学意义(P<0.05);两组脑脊液特异性抗体IgM阳性率均大于IgG阳性率,差异有统计学意义(P<0.05);两组脑脊液均存在白细胞数量异常,但差异无统计学意义(P>0.05);轻症组预后优于重症组,差异有统计学意义(P<0.05)。结论 单纯疱疹病毒性脑炎的临床症状与其他病毒性脑炎区别不大,头颅MRI结合脑脊液特异性抗体检查对于早期诊断单纯疱疹病毒性脑炎更有价值。
Abstract:
Objective To investigate the clinical features and prognostic factors of herpes simplex encephalitis in children.Methods A total of 80 children with herpes simplex encephalitis diagnosed in our hospital from June 2018 to September 2021 were randomly selected and divided into mild group and severe group according to the degree of symptoms, with 40 cases in each group. The clinical manifestations, head MRI and cerebrospinal fluid examination results and prognosis follow-up brain damage were compared between the two groups.Results Patients in both groups had different degrees of clinical symptoms, while the proportion of fever, convulsion and epilepsy in the mild group was less than that in the severe group, and the difference was statistically significant (P<0.05). There was no significant difference in the proportion of headache and vomiting symptoms between the two groups (P>0.05). The incidence of abnormal MRI signal and intracerebral hemorrhage in the severe group was higher than that in the mild group, and the difference was statistically significant (P<0.05). The positive rate of CSF specific antibody IgM in the two groups was higher than that of IgG, and the difference was statistically significant (P<0.05). There was no significant difference in the number of white blood cells in cerebrospinal fluid between the two groups (P>0.05). The prognosis of the mild group was better than that of the severe group, and the difference was statistically significant (P<0.05).Conclusion The clinical symptoms of herpes simplex virus encephalitis are not significantly different from other viral encephalitis. Head MRI combined with cerebrospinal fluid specific antibody examination is more valuable for early diagnosis of herpes simplex virus encephalitis.

参考文献/References:

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更新日期/Last Update: 1900-01-01