[1]安 静.孟鲁司特钠联合特布他林对哮喘患儿呼吸功能的影响[J].医学信息,2022,35(21):128-130.[doi:10.3969/j.issn.1006-1959.2022.21.033]
　AN Jing.Effect of Montelukast Sodium Combined with Terbutaline on Respiratory Function in Children with Asthma[J].Journal of Medical Information,2022,35(21):128-130.[doi:10.3969/j.issn.1006-1959.2022.21.033]
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孟鲁司特钠联合特布他林对哮喘患儿呼吸功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年21期
页码:
128-130
栏目:
药物与临床
出版日期:
2022-11-01

文章信息/Info

Title:
Effect of Montelukast Sodium Combined with Terbutaline on Respiratory Function in Children with Asthma
文章编号:
1006-1959（2022）21-0128-03
作者:
安 静
（佳木斯市中心医院药剂科，黑龙江 佳木斯 154002）
Author(s):
AN Jing
(Department of Pharmacy,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
哮喘; 孟鲁司特钠; 特布他林; 肺功能; 呼吸功能
Keywords:
Asthma; Montelukast sodium; Terbutaline; Lung function; Respiratory function
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2022.21.033
文献标志码:
A
摘要:
目的 探讨孟鲁司特钠与特布他林联合用药治疗哮喘患儿的临床疗效及其对呼吸功能的影响。方法 选择2020年5月-2021年9月我院收治的40例哮喘患儿作为研究对象，采用随机数字表法随机分为对照组与联合治疗组，各20例。对照组予以常规治疗及特布他林治疗，联合治疗组在对照组基础上给予孟鲁司特钠治疗。比较两组临床疗效、肺功能指标水平[第1 s用力呼气容积（FEV1）及其与用力肺活量（FVC）百分比（FEV1/FVC）、最大呼气流速（PEF）]以及呼吸力学指标水平[动态顺应性（Cdyn）、气道阻力（Raw）、气道峰压（PIP）和呼吸作功（WOB）]。结果 联合治疗组临床疗效为95.00%，高于对照组的65.00%，差异有统计学意义（P＜0.05）；联合治疗组FVC、FEV1、FEV1/FVC、PEF以及Cdyn指标水平均高于对照组，Raw、PIP和WOB指标水平低于对照组，差异均有统计学意义（P＜0.05）。结论 孟鲁司特钠与特布他林联合治疗小儿哮喘的临床疗效确切，能有效改善患儿哮喘临床症状及肺功能，且联合用药安全性较高。
Abstract:
Objective To investigate the clinical efficacy of montelukast sodium combined with terbutaline in the treatment of children with asthma and its effect on respiratory function.Methods A total of 40 children with asthma admitted to our hospital from May 2020 to September 2021 were selected as the research objects. They were randomly divided into control group and combined treatment group by random number table method, with 20 cases in each group. The control group was treated with conventional therapy and terbutaline, and the combined treatment group was treated with montelukast sodium on the basis of the control group. The clinical efficacy, lung function indexes [forced expiratory volume in the first second (FEV1) and its percentage with forced vital capacity (FEV1/FVC), peak expiratory flow (PEF)] and respiratory mechanics indexes [dynamic compliance ( Cdyn), airway resistance (Raw), peak airway pressure (PIP) and work of breathing (WOB)] were compared between the two groups.Results The clinical efficacy of the combined treatment group was 95.00%, which was higher than 65.00% of the control group, and the difference was statistically significant (P<0.05). The levels of FVC, FEV1, FEV1/FVC, PEF and Cdyn in the combined treatment group were higher than those in the control group, and the levels of Raw, PIP and WOB were lower than those in the control group, and the difference was statistically significant (P<0.05).Conclusion The clinical efficacy of montelukast sodium combined with terbutaline in the treatment of children with asthma is definite, which can effectively improve the clinical symptoms and lung function of children with asthma, and the safety of combined medication is high.

参考文献/References:

[1]Nair P,Wenzel S,Rabe KF,et al.Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma[J].N Engl J Med,2017,376(25):2448-2458.[2]Axelsson I,Naumburg E,Prietsch SO,et al.Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth[J].Cochrane Database Syst Rev,2019,6(6):CD010126.[3]Pernell BM,DeBaun MR,Becker K,et al.Improving Medication Adherence with Two-way Short Message Service Reminders in Sickle Cell Disease and Asthma. A feasibility randomized controlled trial[J].Appl Clin Inform,2017,8(2):541-559.[4]Irvin C,Zafar I,Good J,et al.Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma[J].J Allergy Clin Immunol,2014,134(5):1175-1186.[5]牛文忠,丁显春.长期吸入糖皮质激素对支气管哮喘患儿生长指标的影响[J].中国生化药物杂志,2015,35(10):108-109,112. [6]Khammy MM,Truong CKH,Wright CE,et al.The β2-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak α1-adrenoceptor antagonists[J].Eur J Pharmacol,2020,882:173304.[7]Ayed K,Khalifa ILH,Mokaddem S,et al.Paradoxical bronchoconstriction caused by β2-adrenoceptor agonists[J].Drug Target Insights,2020,14:12-15.[8]Luo H,Han H,Liu X,et al.Efficacy and safety of montelukast sodium combined with fluticasone in the treatment of adult bronchial asthma: A protocol for systematic review and meta-analysis[J].Medicine (Baltimore),2020,99(52):e23453.[9]Chen L,Huang M,Xie N.The effect of montelukast sodium plus budesonide on the clinical efficacy, inflammation, and pulmonary function in children with cough variant asthma[J].Am J Transl Res,2021,13(6):6807-6816.[10]郭芳芳.孟鲁司特钠治疗中重度支气管哮喘的疗效及其对炎性因子与肺功能的影响[J].实用医药杂志,2021,38(7):605-608.[11]Wu X,Gao S,Lian Y.Effects of continuous aerobic exercise on lung function and quality of life with asthma: a systematic review and meta-analysis[J].J Thorac Dis,2020,12(9):4781-4795.[12]Kor CT,Lin KH,Wang CH,et al.Ventilator Parameters in the Diagnosis and Prognosis of Acute Respiratory Distress Syndrome in Postoperative Patients: A Preliminary Study[J].Diagnostics (Basel),2021,11(4):648.[13]闫永彬,贾长虹,杨明江.从伏风暗瘀宿痰辨治小儿哮喘[J].中医杂志,2016,57(21):1877-1878,1881. [14]熊必丹,喻晓,石克华.咳喘散穴位敷贴联合喘可治穴位注射治疗支气管哮喘临床研究[J].国际中医中药杂志,2020,42(7):644-647.[15]Murray CS,Foden P,Sumner H,et al.Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers[J].Am J Respir Crit Care Med,2017,196(2):150-158.[16]Ye YM,Kim SH,Hur GY,et al.Addition of Montelikast to Low Dose Inhaled Corticosteroid Leads to Fewer Exacerbations in Older Patients Than Medium-Dose Inhaled Corticosteroid Monotherapy[J].Allergy Asthma Imminolres,2015,7(5):440-448.[17]施雪梅.普米克令舒治疗小儿哮喘急性发作的疗效及对肺功能的影响[J].中西医结合心血管病电子杂志,2020,8(35):37.[18]赵焕平.布地奈德联合硫酸沙丁胺醇雾化吸入治疗小儿哮喘疗效评价[J].中西医结合心血管病电子杂志,2020,8(10):53.[19]Doymaz S,Schneider J.Safety of Terbutaline for Treatment of Acute Severe Pediatric Asthma[J].Pediatr Emerg Care,2018,34(5):299-302.[20]邸翔,葛宾,吴小磊.维生素D3联合孟鲁司特钠治疗小儿支气管哮喘临床疗效研究[J].创伤与急危重病医学,2021,9(5):361-364.

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更新日期/Last Update: 1900-01-01