[1]陈 杭.蒙脱石散联合金双歧治疗急性非感染性腹泻的临床疗效及安全性研究[J].医学信息,2022,35(24):139-141.[doi:10.3969/j.issn.1006-1959.2022.24.029]
　CHEN Hang.Study on the Clinical Efficacy and Safety of Montmorillonite Powder Combined with Golden Bifid in the Treatment of Acute Non-infectious Diarrhea[J].Journal of Medical Information,2022,35(24):139-141.[doi:10.3969/j.issn.1006-1959.2022.24.029]
点击复制

蒙脱石散联合金双歧治疗急性非感染性腹泻的临床疗效及安全性研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年24期
页码:
139-141
栏目:
药物与临床
出版日期:
2022-12-15

文章信息/Info

Title:
Study on the Clinical Efficacy and Safety of Montmorillonite Powder Combined with Golden Bifid in the Treatment of Acute Non-infectious Diarrhea
文章编号:
1006-1959（2022）24-0139-03
作者:
陈 杭
（天津市西青医院药剂科，天津 101200）
Author(s):
CHEN Hang
(Department of Pharmacy,Tianjin Xiqing Hospital,Tianjin 101200,China)
关键词:
蒙脱石散; 金双歧; 急性非感染性腹泻; 内毒素; 炎症因子
Keywords:
Montmorillonite powder; Golden bifid; Acute non-infectious diarrhea; Endotoxin; Inflammatory factors
分类号:
R574.62
DOI:
10.3969/j.issn.1006-1959.2022.24.029
文献标志码:
A
摘要:
目的 观察蒙脱石散联合金双歧治疗急性非感染性腹泻的临床疗效及安全性。方法 选取2021年5月-10月在我院诊治的252例急性非感染性腹泻患者为研究对象，采用随机数字表法分为对照组和观察组，各126例。对照组采用蒙脱石散治疗，观察组在对照组基础上联合金双歧治疗，比较两组临床疗效、症状消失时间、症状评分、内毒素和炎症因子水平、不良反应发生情况。结果 观察组治疗总有效率为95.23%，高于对照组的88.09%（P＜0.05）；观察组腹痛、腹泻、呕吐消失时间均短于对照组（P＜0.05）；两组恶心呕吐、大便稀薄、脱水评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组内毒素、白细胞、C反应蛋白水平均低于治疗前，且观察组低于对照组（P＜0.05）；观察组不良反应发生率为3.96%，与对照组的5.55%比较，差异无统计学意义（P＞0.05）。结论 蒙脱石散联合金双歧治疗急性非感染性腹泻效果确切，可提高治疗总有效率，减轻临床症状，促进症状快速消失，降低内毒素和炎症因子水平，且不会增加临床不良反应，是一种安全、有效的治疗方法，值得临床应用。
Abstract:
Objective To observe the clinical efficacy and safety of montmorillonite powder combined with golden bifid in the treatment of acute non-infectious diarrhea.Methods A total of 252 patients with acute non-infectious diarrhea diagnosed and treated in our hospital from May to October 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 126 cases in each group. The control group was treated with montmorillonite powder, and the observation group was treated with golden bifid on the basis of the control group. The clinical efficacy, symptom disappearance time, symptom score, endotoxin and inflammatory factor levels, and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.23%, which was higher than 88.09% in the control group (P<0.05). The disappearance time of abdominal pain, diarrhea and vomiting in the observation group was shorter than that in the control group (P<0.05). The scores of nausea and vomiting, thin stool and dehydration in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). The levels of endotoxin, white blood cells and C-reactive protein in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). The incidence of adverse reactions in the observation group was 3.96%, which was compared with 5.55% in the control group, the difference was not statistically significant (P>0.05).Conclusion Montmorillonite powder combined with golden bifid is effective in the treatment of acute non-infectious diarrhea, which can improve the total effective rate of treatment, reduce clinical symptoms, promote the rapid disappearance of symptoms, reduce the levels of endotoxin and inflammatory factors, and will not increase clinical adverse reactions. It is a safe and effective treatment method and is worthy of clinical application.

参考文献/References:

[1]应贤豪.枫蓼肠胃康颗粒联合双歧杆菌三联活菌胶囊治疗急性感染性腹泻临床研究[J].新中医,2020,52(6):56-58.[2]李甜甜,张斐,刘志威.枫蓼肠胃康胶囊联合双歧杆菌三联活菌胶囊治疗急性感染性腹泻的临床观察[J].中西医结合研究,2019,11(1):16-17.[3]Alebel A,Tesema C,Temesgen B,et al.Prevalence and de- terminants of diarrhea among under-five children in Ethiopia: A systematic review and meta-analysis[J].PLoS One,2018,13(6):e199684.[4]中华医学会儿科学分会消化学组,《中华儿科杂志》编辑委员会.中国儿童急性感染性腹泻病临床实践指南[J].中华儿科杂志,2016,54(7):483-488.[5]王笑娜,张新昕,蒋维.枫蓼肠胃康联合盐酸洛美沙星治疗大学生急性胃肠炎疗效观察[J].中国校医,2017,31(11):826,828.[6]季顺祥,黄惠风.氟哌噻吨美利曲辛联合枫蓼肠胃康治疗腹泻型肠易激综合征疗效观察[J].内蒙古中医药,2017,36(19):75-76.[7]张湘玲,杨慧湘,伍永娥,等.双歧杆菌三联活菌加蒙脱石散联合赖氨葡锌颗粒治疗小儿腹泻62例疗效观察[J].贵州医药,2016,40(4):381-382.[8]陈美如,张丽贤,田志颖,等.谷氨酰胺与思密达治疗非感染性腹泻的疗效对比[J].检验医学与临床,2017,14(4):552-553.[9]李建勋,孟立娜.微生态制剂在非感染性腹泻中的临床应用[J].胃肠病学,2016,21(6):369-371.[10]刘俊娥.对比推拿联合针刺穴位与蒙脱石散治疗小儿非感染性腹泻的临床疗效及分析[J].中国中医基础医学杂志,2018,21(3):87-89.[11]梁忠培,杨力,邓昌枢,等.参苓白术散加减辅助推拿辩证治疗小儿急性轮状病毒感染性腹泻的临床疗效研究[J].中华医院感染学杂志,2017,27(22):5262-5265.[12]Abuzerr S,Nasseri S,Yunesian M,et al.Water,sanitation,and hy giene risk factors of acute diarrhea among children under five years in the Gaza Strip[J].Journal of Water,Sanitation and Hygiene for Development,2020,10(1):111-123.[13]柴焕然.双歧杆菌四联活菌片联合蒙脱石散治疗非感染性腹泻患儿[J].实用中西医结合临床,2019,19(1):40-42.[14]尚朋娟,杨芳芳.美洛西林钠联合四联双歧杆菌对感染性腹泻患儿炎性因子与肠道功能的影响[J].广西医科大学学报,2019,36(2):258-262.[15]李静.蒙脱石散与金双歧片联合治疗小儿急性腹泻的临床疗效分析[J].中国妇幼保健,2017,32(4):741-743.[16]别川定,赵琳琳.双歧杆菌三联活菌对急性感染性腹泻患儿肠道黏膜屏障功能及菌群的影响[J].临床合理用药杂志,2019,12(16):46-47.[17]戴义娟,王涛,初晨.肠胃康颗粒联合质子泵抑制剂用于感染性腹泻患者的效果观察[J].世界中医药,2020,15(7):2127-2129.

相似文献/References:

[1]廖道明,朱 茜.双岐四联活菌片联合蒙脱石散治疗小儿腹泻临床疗效观察[J].医学信息,2019,32(06):159.[doi:10.3969/j.issn.1006-1959.2019.06.051]
　LIAO Dao-ming,ZHU Qian.Clinical Observation of the Treatment of Diarrhea in Children with Bifidobacterium Tetracycline Tablet Combined with Montmorillonite Powder[J].Journal of Medical Information,2019,32(24):159.[doi:10.3969/j.issn.1006-1959.2019.06.051]
[2]冯宏达,高 翔.双歧三联活菌片联合蒙脱石散治疗小儿腹泻的疗效[J].医学信息,2020,33(15):144.[doi:10.3969/j.issn.1006-1959.2020.15.045]
　FENG Hong-da,GAO Xiang.Clinical Effect of Bifid Triple Viable Bacteria Tablets Combined with MontmorillonitePowder in the Treatment of Infantile Diarrhea[J].Journal of Medical Information,2020,33(24):144.[doi:10.3969/j.issn.1006-1959.2020.15.045]
[3]陶仲宾,王 洁,杨亚玲.宝乐安辅助治疗儿童反复呼吸道感染继发性腹泻的临床疗效[J].医学信息,2021,34(05):158.[doi:10.3969/j.issn.1006-1959.2021.05.045]
　TAO Zhong-bin,WANG Jie,YANG Ya-ling.The Clinical Efficacy of Baolean in Adjuvant Treatment of Diarrhea Secondary to RecurrentRespiratory Infections in Children[J].Journal of Medical Information,2021,34(24):158.[doi:10.3969/j.issn.1006-1959.2021.05.045]
[4]赵荣杰.枯草杆菌二联活菌颗粒联合蒙脱石散对小儿腹泻免疫功能及炎性状态的影响[J].医学信息,2021,34(16):169.[doi:10.3969/j.issn.1006-1959.2021.16.048]
　ZHAO Rong-jie.Effect of Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines,Live Combined with Montmorillonite Powder on Immune Function and Inflammatory State of Children with Diarrhea[J].Journal of Medical Information,2021,34(24):169.[doi:10.3969/j.issn.1006-1959.2021.16.048]

更新日期/Last Update: 1900-01-01