[1]裴艳莹,周雯雯.神经节苷脂治疗新生儿缺氧缺血性脑病的临床效果及其对肿瘤坏死因子α和白细胞介素6的影响[J].医学信息,2023,36(01):122-125.[doi:10.3969/j.issn.1006-1959.2023.01.024]
　PEI Yan-ying,ZHOU Wen-wen.Clinical Effect of Ganglioside in the Treatment of Neonatal Hypoxic Ischemic Encephalopathy and its Effect on Tumor Necrosis Factor-α and Interleukin-6[J].Journal of Medical Information,2023,36(01):122-125.[doi:10.3969/j.issn.1006-1959.2023.01.024]
点击复制

神经节苷脂治疗新生儿缺氧缺血性脑病的临床效果及其对肿瘤坏死因子α和白细胞介素6的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年01期
页码:
122-125
栏目:
论著
出版日期:
2023-01-01

文章信息/Info

Title:
Clinical Effect of Ganglioside in the Treatment of Neonatal Hypoxic Ischemic Encephalopathy and its Effect on Tumor Necrosis Factor-α and Interleukin-6
文章编号:
1006-1959（2023）01-0122-04
作者:
裴艳莹; 周雯雯
（佳木斯市中心医院儿科，黑龙江 佳木斯 154002）
Author(s):
PEI Yan-ying; ZHOU Wen-wen
(Department of Pediatrics,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
神经节苷脂; 新生儿缺氧缺血性脑病; 炎性因子; 神经功能; 血气指标
Keywords:
Ganglioside; Neonatal hypoxic-ischemic encephalopathy; Inflammatory factors; Neurological function; Blood gas indexes
分类号:
R742
DOI:
10.3969/j.issn.1006-1959.2023.01.024
文献标志码:
A
摘要:
目的 探究神经节苷脂治疗新生儿缺氧缺血性脑病（HIE）的临床效果及其对肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的影响。方法 选取2020年1月-2021年12月佳木斯市中心医院收治的50例HIE患儿，经随机数字表法分为对照组（25例）和观察组（25例）。对照组行常规治疗，观察组在其基础上加用神经节苷脂治疗，比较两组临床疗效、血气指标[动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、血氧饱和度（SaO2）]、血清炎性因子[TNF-α、IL-6、超敏C反应蛋白（hs-CRP）]、新生儿神经行为测定（NBNA）评分。结果 观察组治疗有效率较对照组高（P＜0.05）；两组治疗后PaO2、SaO2升高，PaCO2下降，且观察组PaO2、SaO2高于对照组，PaCO2低于对照组（P＜0.05）；两组治疗后TNF-α、IL-6、hs-CRP均有下降，且观察组低于对照组（P＜0.05）；两组治疗后NBNA评分均有升高，且观察组高于对照组（P＜0.05）。结论 神经节苷脂治疗HIE疗效确切，可改善患儿血氧状态，减轻炎性反应，促使神经修复。
Abstract:
Objective To investigate the clinical effect of ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy (HIE) and its effect on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6).Methods Fifty children with HIE admitted to Jiamusi Central Hospital from January 2020 to December 2021 were selected and divided into control group (25 cases) and observation group (25 cases) by random number table method. The control group was treated with routine treatment, and the observation group was treated with ganglioside on the basis of the control group. The clinical efficacy, blood gas indexes [arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), saturation of blood oxygen (SaO2)], serum inflammatory factors [TNF-α, IL-6, hypersensitive C-reactive protein (hs-CRP)] and neonatal behavioral neurological assessment (NBNA) score were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, PaO2 and SaO2 increased and PaCO2 decreased in the two groups, and PaO2 and SaO2 in the observation group were higher than those in the control group, and PaCO2 was lower than that in the control group (P<0.05)). After treatment, TNF-α, IL-6 and hs-CRP in the two groups decreased, and those in the observation group were lower than those in the control group (P<0.05). The NBNA scores of the two groups increased after treatment, and those in the observation group were higher than those in the control group (P<0.05).Conclusion Ganglioside is effective in the treatment of HIE, which can improve the blood oxygen state, reduce the inflammatory reaction and promote nerve repair.

参考文献/References:

[1]Wu Z,Xie C,Kuang H,et al.Oxytocin mediates neuroprotection against hypoxic-ischemic injury in hippocampal CA1 neuron of neonatal rats[J].Neuropharmacology,2021,187:108488.[2]曹红利,张建霞.神经节苷脂联合重组人促红素治疗新生儿缺氧缺血性脑病的疗效[J].中国药物与临床,2020,20(23):3993-3995.[3]王文全.头部亚低温联合神经节苷脂治疗新生儿缺氧缺血性脑病的疗效[J].中国农村卫生,2020,12(18):31.[4]吴新婷,卞伟妮,郑玲芳,等.胞二磷胆碱联合单唾液酸四己糖神经节苷脂钠治疗新生儿缺氧缺血性脑病的疗效观察[J].中国医院用药评价与分析,2020,20(7):785-787,791.[5]周伟,毕叶,魏燕燕,等.亚低温联合神经节苷脂治疗新生儿缺氧缺血性脑病的疗效分析[J].解放军医学院学报,2020,41(1):56-59.[6]郭若男,郭瑞,魏洁如,等.神经节苷脂联合高压氧治疗新生儿缺氧缺血性脑病疗效分析[J].中国药业,2019,28(19):68-70.[7]陈小娜,姜毅.2018昆士兰临床指南:缺氧缺血性脑病介绍[J].中华新生儿科杂志,2019,34(1):77-78.[8]蒋豪明,陈翔,李珍,等.单唾液酸四己糖神经节苷脂联合鼠神经生长因子对新生儿缺氧缺血性脑病的临床研究[J].中国临床药理学与治疗学,2019,24(3):301-306.[9]吴云刚,李雯洁,鲁连海,等.神经节苷脂联合亚低温治疗新生儿窒息并发缺氧缺血性脑病的疗效观察[J].安徽医学,2018,39(12):1431-1434.[10]Ziemka-Nalecz M,Jaworska J,Sypecka J,et al.Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia[J].Molecular Neurobiology,2017,54(1):5300-5318.[11]马萍璇,黄海川,陈楷正.单唾液酸四己糖神经节苷脂联合1,6-二磷酸果糖对新生儿窒息并发缺血缺氧性脑病患儿心功能、肾功能和血糖的影响[J].广西医科大学学报,2017,34(12):1768-1771.[12]Critchley DR,Streuli CH,Kellie S,et al.Characterization of the cholera toxin receptor on Balb/c 3T3 cells as a ganglioside similar to, or identical with, ganglioside GM1. No evidence for galactoproteins with receptor activity[J].The Biochemical journal,2019,13(1):209-219.[13]者桂莲,张靖,霍志艳,等.单唾液酸四己糖神经节苷脂与胞二磷胆碱对中度新生儿缺血缺氧性脑病的干预效果比较[J].临床药物治疗杂志,2018,16(6):81-85.[14]唐国红,雷克竞.鼠神经生长因子联合神经节苷脂治疗新生儿缺氧缺血性脑病的临床观察[J].中国药房,2017,28(17):2384-2388.[15]张艺森,李战华.促红细胞生成素联合神经节苷脂对新生儿缺氧缺血性脑病的疗效观察[J].国际医药卫生导报,2017,23(8):1223-1225.[16]易爽,余波,庞侯旭.磷酸肌酸钠联合神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效[J].川北医学院学报,2021,36(5):588-591.[17]陈小娟,冯茂霭,梁煜潮.促红细胞生成素联合单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病的效果[J].广东医学,2017,38(5):784-785,789.[18]胡玉莲,徐淑玲,邓彩艳,等.头部亚低温联合神经节苷脂治疗新生儿缺氧缺血性脑病的疗效[J].中国实用神经疾病杂志,2017,20(4):102-104.[19]陈茜娜,徐棉,林振浪,等.单唾液酸四己糖神经节苷脂联合头部亚低温治疗对新生儿缺氧缺血性脑病的疗效观察[J].浙江医学,2017,39(1):40-42,45.[20]李小晶,朱海霞,甘颖妍,等.神经节苷脂治疗新生儿缺氧缺血性脑病对血气及血清炎症因子水平的影响[J].海南医学院学报,2017,23(4):549-552.[21]任亚方,张焕新,张靖.rhEPO联合GM1治疗重度新生儿缺氧缺血性脑病的临床疗效观察[J].重庆医学,2018,47(6):824-827.[22]李科兴,邹奕,张丽娇.神经节苷脂在改善新生儿缺氧缺血性脑病脑血流及神经功能指标中的效果[J].昆明医科大学学报,2017,38(4):113-116.[23]果崇慧,杨青.神经节苷脂治疗新生儿缺氧缺血性脑病对患儿血清炎症相关细胞因子和MMP-9的影响[J].河北医药,2018,40(2):219-223.[24]高军.神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病的疗效与NPY、β-EP、NSE及炎性因子的临床价值[J].中国妇幼保健,2019,34(13):3000-3003.

相似文献/References:

[1]许红玉,梅育嘉,罗杰峰.神经节苷脂联合复方左旋多巴治疗帕金森病的效果[J].医学信息,2021,34(03):160.[doi:10.3969/j.issn.1006-1959.2021.03.045]
　XU Hong-yu,MEI Yu-jia,LUO Jie-feng.The Effect of Ganglioside Combined with Benserazide in the Treatment of Parkinson’s Disease[J].Journal of Medical Information,2021,34(01):160.[doi:10.3969/j.issn.1006-1959.2021.03.045]
[2]吕艳丽.甲基强的松龙联合神经节苷脂治疗急性脊髓炎的疗效[J].医学信息,2021,34(10):164.[doi:10.3969/j.issn.1006-1959.2021.10.048]
　LYU Yan-li.Efficacy of Methylprednisolone Combined with Ganglioside in the Treatment of Acute Myelitis[J].Journal of Medical Information,2021,34(01):164.[doi:10.3969/j.issn.1006-1959.2021.10.048]
[3]李含阳,张 玉,于 莹.大剂量甲基泼尼松龙冲击联合神经节苷脂治疗对急性脊髓炎患者炎症反应、免疫平衡的影响[J].医学信息,2023,36(08):135.[doi:10.3969/j.issn.1006-1959.2023.08.029]
　LI Han-yang,ZHANG Yu,YU Ying.Effect of High-dose Methylprednisolone Pulse Therapy Combined with Ganglioside on Inflammatory Response and Immune Balance in Patients with Acute Myelitis[J].Journal of Medical Information,2023,36(01):135.[doi:10.3969/j.issn.1006-1959.2023.08.029]

更新日期/Last Update: 1900-01-01