[1]高晓梅,赵 蓉,李慧珍,等.妊娠期糖尿病中相关长链非编码RNAs的研究[J].医学信息,2023,36(11):175-179.[doi:10.3969/j.issn.1006-1959.2023.11.038]
 GAO Xiao-mei,ZHAO Rong,LI Hui-zhen,et al.Study on Long Non-coding RNAs in Gestational Diabetes Mellitus[J].Journal of Medical Information,2023,36(11):175-179.[doi:10.3969/j.issn.1006-1959.2023.11.038]
点击复制

妊娠期糖尿病中相关长链非编码RNAs的研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年11期
页码:
175-179
栏目:
综述
出版日期:
2023-06-01

文章信息/Info

Title:
Study on Long Non-coding RNAs in Gestational Diabetes Mellitus
文章编号:
1006-1959(2023)11-0175-05
作者:
高晓梅赵 蓉李慧珍
(1.广东医科大学研究生院,广东 湛江 524001;2.广东医科大学附属医院妇产科,广东 湛江 524001)
Author(s):
GAO Xiao-meiZHAO RongLI Hui-zhenet al.
(1.Graduate School of Guangdong Medical University,Zhanjiang 524001,Guangdong,China;2.Department of Obstetrics and Gynecology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,Guangdong,China)
关键词:
妊娠期糖尿病长链非编码RNAs代谢性疾病生物标志物治疗靶点
Keywords:
Gestational diabetes mellitusLong-chain non-coding RNAsMetabolic diseasesBiomarkersTherapeutic target
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2023.11.038
文献标志码:
A
摘要:
妊娠期糖尿病是妊娠期较常见的一种疾病,可致孕妇流产、早产以及娩出巨大儿、畸形儿等风险增加,并增加母亲及后代远期代谢性疾病的患病风险,所以早期诊疗具有重要意义。长链非编码RNAs(lncRNAs)是长度超过200个核苷酸的一类非编码RNAs,它不直接编码蛋白质,但在基因的转录和表达等生物学过程中发挥重要作用。目前的一些研究表明,lncRNAs可通过调节胎盘滋养细胞的增殖、迁移和侵袭等活动参与妊娠期糖尿病的发病。lncRNAs为妊娠期糖尿病的发病机制提供了新见解,其有望成为妊娠期糖尿病潜在的发病生物标志物及治疗靶点。本文就妊娠期糖尿病相关的lncRNAs的研究进展作一综述,以期对疾病进行更好的预防和诊疗。
Abstract:
Gestational diabetes mellitus is a common disease in pregnancy, which can increase the risk of abortion, premature delivery, giant infant and oaf childbirth, and increase the risk of long-term metabolic diseases of mothers and offspring, so early diagnosis and treatment is of great significance. Long non-coding RNAs ( lncRNAs ) are a class of non-coding RNAs with a length of more than 200 nucleotides. They do not directly encode proteins, but play an important role in biological processes such as gene transcription and expression. Some current studies have shown that lncRNAs can participate in the pathogenesis of gestational diabetes by regulating the proliferation, migration and invasion of placental trophoblast cells. LncRNAs provide new insights into the pathogenesis of gestational diabetes mellitus, which are expected to become potential biomarkers and therapeutic targets for gestational diabetes mellitus. This article reviews the research progress of lncRNAs related to gestational diabetes in order to better prevent and treat the disease.

参考文献/References:

[1]American Diabetes Association.(2) Classification and diagnosis of diabetes[J].Diabetes Care,2015,38Suppl:S8-S16.[2]Geiger J,Dalgaard LT.Interplay of mitochondrial metabolism and microRNAs [J].Cell Mol Life Sci,2017,74(4):631-646.[3]Plows JF,Stanley JL,Baker PN,et al.The Pathophysiology of Gestational Diabetes Mellitus [J].Int J Mol Sci,2018,19(11):3342.[4]Damm P,Houshmand-Oeregaard A,Kelstrup L,et al.Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark[J].Diabetologia,2016,59(7):1396-1399.[5]Zeng Y,Ren K,Zhu X,et al.Long Noncoding RNAs: Advances in Lipid Metabolism[J].Adv Clin Chem,2018,87:1-36.[6]Ponting CP,Oliver PL,Reik W.Evolution and functions of long noncoding RNAs[J].Cell,2009,136(4):629-641.[7]Wang KC,Chang HY.Molecular mechanisms of long noncoding RNAs[J].Mol Cell,2011,43(6):904-914.[8]Hu XY,Hou PF,Li TT,et al.The roles of Wnt/β-catenin signaling pathway related lncRNAs in cancer[J].Int J Biol Sci,2018,14(14):2003-2011.[9]Morán I,Akerman I,van de Bunt M,et al.Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes[J].Cell Metab,2012,16(4):435-448.[10]Huang C,Huang BB,Niu JM,et al.Global mRNA and Long Non-Coding RNA Expression in the Placenta and White Adipose Tissue of Mice Fed a High-Fat Diet During Pregnancy[J].Cell Physiol Biochem,2018,50(6):2260-2271.[11]Tao H,Liu X,Liu X,et al.LncRNA MEG3 inhibits trophoblast invasion and trophoblast-mediated VSMC loss in uterine spiral artery remodeling[J].Mol Reprod Dev,2019,86(6):686-695.[12]Azari I,Ghafouri-Fard S,Omrani MD,et al.Expression of Long Non-Coding RNAs in Placentas of Intrauterine Growth Restriction (IUGR) Pregnancies[J].Rep Biochem Mol Biol,2019;8(1):25-31.[13]Leng L,Zhang C,Ren L,et al.Construction of a long non coding RNA-mediated competitive endogenous RNA network reveals global patterns and regulatory markers in gestational diabetes[J].Int J Mol Med,2019,43(2):927-935.[14]Tang L,Li P,Li L.Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus[J].J Diabetes Investig,2020,11(5):1307-1317.[15]Cao M,Zhang L,Lin Y,et al.Differential mRNA and Long Noncoding RNA Expression Profiles in Umbilical Cord Blood Exosomes from Gestational Diabetes Mellitus Patients[J].DNA Cell Biol,2020,39(11):2005-2016.[16]Li X,Zeng L,Cao C,et al.Long noncoding RNA MALAT1 regulates renal tubular epithelial pyroptosis by modulated miR-23c targeting of ELAVL1 in diabetic nephropathy[J].Exp Cell Res,2017,350(2):327-335.[17]Han Y,Qiu H,Pei X,et al.Low-dose Sinapic Acid Abates the Pyroptosis of Macrophages by Downregulation of lncRNA-MALAT1 in Rats With Diabetic Atherosclerosis[J].J Cardiovasc Pharmacol,2018,71(2):104-112.[18]Hu M,Wang R,Li X,et al.LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with β-catenin[J].J Cell Mol Med,2017,21(11):2732-2747.[19]Yan B,Tao ZF,Li XM,et al.Aberrant expression of long noncoding RNAs in early diabetic retinopathy[J].Invest Ophthalmol Vis Sci,2014,55(2):941-951.[20]Zhang M,Gu H,Chen J,et al.Involvement of long noncoding RNA MALAT1 in the ,pathogenesis of diabetic cardiomyopathy[J].Int J Cardiol,2016,202:753-755.[21]Zhang Y,Qu L,Ni H,et al.Expression and function of lncRNA MALAT1 in gestational diabetes mellitus[J].Adv Clin Exp Med,2020,29(8):903-910.[22]Zhang Y,Wu H,Wang F,et al.Long non-coding RNA MALAT1 expression in patients with gestational diabetes mellitus[J].Int J Gynaecol Obstet,2018,140(2):164-169.[23]李丽,刘素新,霍琰,等.lncRNA MALAT1在妊娠期糖尿病孕妇血清中的表达水平及临床意义[J].中国妇幼保健,2019,34(6):1264-1267.[24]Miyoshi N,Wagatsuma H,Wakana S,et al.Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q[J].Genes Cells,2000,5(3):211-220.[25]Zhang X,Zhou Y,Mehta KR,et al.A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells[J].J Clin Endocrinol Metab,2003,88(11):5119-5126.[26]Zhu X,Li H,Wu Y,et al.lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression[J].Int J Mol Med,2019,43(1):345-357.[27]孙军萍,黎宗保,韩耀光,等.妊娠糖尿病患者血清 Omentin- 1、IRS-1、IRS-2 与胰岛素抵抗的关系[J].中国妇产科临床杂志,2020,21(1):83-84.[28]Ye HH,Yang SH,Zhang Y.MEG3 damages fetal endothelial function induced by gestational diabetes mellitus via AKT pathway[J].Eur Rev Med Pharmacol Sci,2018,22(24):8553-8560.[29]Zhang H.Mechanism associated with aberrant lncRNA MEG3 expression in gestational diabetes mellitus[J].Exp Ther Med,2019,18(5):3699-3706.[30]Gao Y,Wu F,Zhou J,et al.The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells[J].Nucleic Acids Res,2014,42(22):13799-13811.[31]Ding GL,Wang FF,Shu J,et al.Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia[J].Diabetes,2012,61(5):1133-1142.[32]Su R,Wang C,Feng H,et al.Alteration in Expression and Methylation of IGF2/H19 in Placenta and Umbilical Cord Blood Are Associated with Macrosomia Exposed to Intrauterine Hyperglycemia[J].PLoS One,2016,11(2):e0148399.[33]Hatada I,Morita S,Obata Y,et al.Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening[J].J Biochem,2001,130(2):187-190.[34]Zhang J,Song L,Ma Y,et al.lncRNA MEG8 Upregulates miR-770-5p Through Methylation and Promotes Cell Apoptosis in Diabetic Nephropathy[J].Diabetes Metab Syndr Obes,2020,13:2477-2483.[35]Zhang W,Cao D,Wang Y,et al.LncRNA MEG8 is upregulated in gestational diabetes mellitus (GDM) and predicted kidney injury[J].J Diabetes Complications,2021,35(1):107749.[36]Cho SW,Xu J,Sun R,et al.Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element[J].Cell,2018,173(6):1398-1412.e22.[37]Cheng Y,Hu Q,Zhou J.Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p[J].Can J Physiol Pharmacol,2021,99(3):303-312. [38]Wang Q,Lu X,Li C,et al.Down-regulated long non-coding RNA PVT1 contributes to gestational diabetes mellitus and preeclampsia via regulation of human trophoblast cells[J].Biomed Pharmacother,2019,120:109501.[39]Amaral PP,Neyt C,Wilkins SJ,et al.Complex architecture and regulated expression of the Sox2ot locus during vertebrate development[J].RNA,2009,15(11):2013-2027.[40]Shahryari A,Rafiee MR,Fouani Y,et al.Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma[J].Stem Cells,2014,32(1):126-134.[41]Ran G,Zhu X,Qin Y.LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events[J].Diabetes Metab Syndr Obes,2021,14:3989-3995.[42]Xu T,Yan S,Jiang L,et al.Gene amplification-driven long noncoding RNA SNHG17 regulates cell proliferation and migration in human non-small-cell lung Cancer[J].Mol Ther Nucleic Acids,2019,17:405-413.[43]Li J,Du B,Geng X,et al.lncRNA SNHG17 is Downregulated in Gestational Diabetes Mellitus (GDM) and Has Predictive Values[J].Diabetes Metab Syndr Obes,2021,14:831-838.[44]Naemura M,Kuroki M,Tsunoda T,et al.The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation[J].Anticancer Res,2018,38(1):77-81.[45]Li Y,Liu L.LncRNA OIP5-AS1 Signatures as a Biomarker of Gestational Diabetes Mellitus and a Regulator on Trophoblast Cells[J].Gynecol Obstet Invest,2021,86(6):509-517.[46]Rinn JL,Kertesz M,Wang JK,et al.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs[J].Cell,2007,129(7):1311-1323.[47]Zhu HP.Silence of HOTAIR inhibits insulin secretion and proliferation in pancreatic β cells[J].Eur Rev Med Pharmacol Sci,2020,24(2):784-792.[48]Su R,Wu X,Ke F.Long Non-Coding RNA HOTAIR Expression and Clinical Significance in Patients with Gestational Diabetes[J].Int J Gen Med,2021,14:9945-9950.[49]Brown CJ,Ballabio A,Rupert JL,et al.A gene from the region of the human X inactivation centre isexpressed exclusively from the inactive X chromosome[J].Nature,1991,349(6304):38-44.[50]Li Y,Yuan X,Shi Z,et al.LncRNA XIST serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell via miR-497-5p/FOXO1 axis[J].Cardiovasc Diagn Ther,2021,11(3):716-725.

相似文献/References:

[1]范新婷.层级护理在妊娠期糖尿病孕妇剖宫产中的应用研究[J].医学信息,2018,31(02):168.[doi:10.3969/j.issn.1006-1959.2018.02.065]
 FAN Xin-ting.Study on the Application of Hierarchical Nursing in Cesarean Section of Pregnant Women with Gestational Diabetes Mellitus[J].Journal of Medical Information,2018,31(11):168.[doi:10.3969/j.issn.1006-1959.2018.02.065]
[2]孟召然,李 玲,范建辉.妊娠期糖尿病相关危险因素分析[J].医学信息,2018,31(04):81.[doi:10.3969/j.issn.1006-1959.2018.04.026]
 MENG Zhao-ran,LI Ling,FAN Jian-hui.Analysis of Risk Factors Related to Gestational Diabetes Mellitus[J].Journal of Medical Information,2018,31(11):81.[doi:10.3969/j.issn.1006-1959.2018.04.026]
[3]王 荣.诺和锐特充治疗妊娠期糖尿病的临床效果观察[J].医学信息,2018,31(08):186.[doi:10.3969/j.issn.1006-1959.2018.08.069]
 WANG Rong.Clinical Observation on the Treatment of Gestational Diabetes Mellitus with Novoterol[J].Journal of Medical Information,2018,31(11):186.[doi:10.3969/j.issn.1006-1959.2018.08.069]
[4]李雪莲.妊娠合并糖尿病对分娩结局的影响观察[J].医学信息,2018,31(10):114.[doi:10.3969/j.issn.1006-1959.2018.10.036]
 LI Xue-lian.Effect of Pregnancy Complicated with Diabetes on Delivery Outcome[J].Journal of Medical Information,2018,31(11):114.[doi:10.3969/j.issn.1006-1959.2018.10.036]
[5]屈利洁.围生期综合护理措施及营养干预对妊娠期糖尿病患者的价值[J].医学信息,2018,31(15):171.[doi:10.3969/j.issn.1006-1959.2018.15.057]
 QU Li-jie.The Value of Perinatal Comprehensive Nursing Measures and Nutritional Intervention in Gestational Diabetes Patients[J].Journal of Medical Information,2018,31(11):171.[doi:10.3969/j.issn.1006-1959.2018.15.057]
[6]刘玉静,朱 静.产后护理管理对妊娠期糖尿病患者血糖控制及疾病认知水平的影响[J].医学信息,2018,31(23):180.[doi:10.3969/j.issn.1006-1959.2018.23.053]
 LIU Yu-jing,ZHU Jing.Effect of Postpartum Nursing Management on Blood Glucose Control and Disease Cognition of Gestational Diabetes Mellitus Patients[J].Journal of Medical Information,2018,31(11):180.[doi:10.3969/j.issn.1006-1959.2018.23.053]
[7]于素芳.妊娠期糖尿病的综合干预及药物治疗[J].医学信息,2019,32(01):59.[doi:10.3969/j.issn.1006-1959.2019.01.020]
 YU Su-fang.Comprehensive Intervention and Drug Therapy for Gestational Diabetes Mellitus[J].Journal of Medical Information,2019,32(11):59.[doi:10.3969/j.issn.1006-1959.2019.01.020]
[8]吴凌云.临床护理路径在妊娠期糖尿病合并妊娠期高血压患者中的应用[J].医学信息,2019,32(10):181.[doi:10.3969/j.issn.1006-1959.2019.10.061]
 WU Ling-yun.Application of Clinical Nursing Pathway in Gestational Diabetes Mellitus Complicated with Gestational Hypertension[J].Journal of Medical Information,2019,32(11):181.[doi:10.3969/j.issn.1006-1959.2019.10.061]
[9]左俊芳,刘沙沙,崔洪艳.妊娠期糖尿病高危因素及预防措施研究[J].医学信息,2022,35(17):177.[doi:10.3969/j.issn.1006-1959.2022.17.048]
 ZUO Jun-fang,LIU Sha-sha,CUI Hong-yan.Study on High Risk Factors and Preventive Measures of Gestational Diabetes Mellitus[J].Journal of Medical Information,2022,35(11):177.[doi:10.3969/j.issn.1006-1959.2022.17.048]
[10]王莎莎.孕期膳食指导改善血脂代谢预防妊娠期糖尿病与 妊娠高血压疾病的研究[J].医学信息,2019,32(18):89.[doi:10.3969/j.issn.1006-1959.2019.18.028]
 WANG Sha-sha.Dietary Guidance during Pregnancy Improves Blood Lipid Metabolism to Prevent Gestational Diabetes Mellitus and Pregnancy-induced Hypertension[J].Journal of Medical Information,2019,32(11):89.[doi:10.3969/j.issn.1006-1959.2019.18.028]

更新日期/Last Update: 1900-01-01