[1]姚慧霞,郭红菊,栾晓倩,等.脑小血管病患者心率变异性与认知功能的相关性[J].医学信息,2023,36(18):110-113.[doi:10.3969/j.issn.1006-1959.2023.18.020]
　YAO Hui-xia,GUO Hong-ju,LUAN Xiao-qian,et al.Correlation Between Heart Rate Variability and Cognitive Function in Patients with Cerebral Small Vessel Disease[J].Journal of Medical Information,2023,36(18):110-113.[doi:10.3969/j.issn.1006-1959.2023.18.020]
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脑小血管病患者心率变异性与认知功能的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年18期
页码:
110-113
栏目:
论著
出版日期:
2023-09-15

文章信息/Info

Title:
Correlation Between Heart Rate Variability and Cognitive Function in Patients with Cerebral Small Vessel Disease
文章编号:
1006-1959（2023）18-0110-04
作者:
姚慧霞; 郭红菊; 栾晓倩; 等
（1.石河子大学医学院，新疆 石河子 832000；2.河南科技大学第二附属医院CCU，河南 洛阳 471000；3.石河子大学第一附属医院老年医学科，新疆 石河子 832000）
Author(s):
YAO Hui-xia; GUO Hong-ju; LUAN Xiao-qian; et al.
(1.Shihezi University School of Medicine,Shihezi 832000,Xinjiang,China;2.CCU of the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China;3.Department of Geriatrics,the First Affiliated Hospital of Shihezi University,Shihezi 832000,Xinjiang,China)
关键词:
脑小血管病; 心率变异性; 认知功能
Keywords:
Cerebral small vessel disease; Heart rate variability; Cognitive function
分类号:
R743
DOI:
10.3969/j.issn.1006-1959.2023.18.020
文献标志码:
A
摘要:
目的 探讨脑小血管病（CSVD）患者心率变异性（HRV）与认知功能的相关性。方法 选取2021年11月-2022年11月在石河子大学医学院第一附属医院就诊的CSVD患者136例，根据蒙特利尔认知评估量表（MoCA）评分结果将患者分为无认知功能障碍组（MoCA≥26分，75例）和认知功能障碍组（MoCA＜26分，61例），比较两组年龄、性别、吸烟史、饮酒史、高血压病史、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、D二聚体及HRV指标，采用Spearman相关分析探讨HRV指标与MoCA评分的相关性，采用二元Logistic回归模型分析CSVD患者认知功能障碍的影响因素。结果 两组年龄、性别、吸烟史、饮酒史、高血压病史、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、D二聚体水平比较，差异无统计学意义（P＞0.05）；认知功能障碍组全部正常窦性心搏RR间期的标准差（SDNN）、全程5 min正常RR间期标准差的平均值（SDNNindex）、相邻正常 RR 间期相差超过 50 ms的心搏数占总窦性心搏数的百分比（PNN50）、低频功率（LF）值均低于无认知功能障碍组（P＜0.05）；Spearman相关分析显示，CSVD患者 MoCA评分与SDNN（r=0.454）、全程每5 min正常RR间期均值的标准差（SDANN）（r=0.260）、SDNNindex（r=0.401）、PNN50（r=0.263）、LF（r=0.347）均呈正相关；多因素Logistic回归分析显示，SDNNindex是脑小血管病患者认知功能障碍的影响因素[OR=0.943，95%CI：0.891~0.999，P=0.045]。结论 SDNNindex是脑小血管病患者认知功能障碍的影响因素。
Abstract:
Objective To investigate the correlation between heart rate variability (HRV) and cognitive function in patients with cerebral small vessel disease (CSVD).Methods A total of 136 patients with CSVD who were treated in the First Affiliated Hospital of Shihezi University School of Medicine from November 2021 to November 2022 were selected. According to the Montreal Cognitive Assessment (MoCA) score, the patients were divided into non-cognitive impairment group (MoCA≥26 scores, 75 patients) and cognitive impairment group (MoCA<26 scores, 61 patients). Age, gender, smoking history, drinking history, hypertension history, triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein, D-dimer and HRV indexes were compared between the two groups. Spearman correlation analysis was used to explore the correlation between HRV index and MoCA score. Binary Logistic regression model was used to analyze the influencing factors of cognitive dysfunction in CSVD patients.Results There was no significant difference in age, sex, smoking history, drinking history, hypertension history, triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein and D-dimer between the two groups (P>0.05). The standard diviation of NN intervals (SDNN), the standard deviation of all 5-minute RR intervals (SDNNindex), the percent of NN50 in the total number of NN intervals (PNN50), and the low frequency power (LF) values in the cognitive dysfunction group were lower than those in the non-cognitive dysfunction group (P<0.05). Spearman correlation analysis showed that MoCA score was positively correlated with SDNN (r=0.454), SDANN (r=0.260), SDNNindex (r=0.401), PNN50 (r=0.263) and LF (r=0.347) in CSVD patients. Multivariate logistic regression analysis showed that SDNNindex was an influencing factor of cognitive dysfunction in patients with cerebral small vessel disease [OR=0.943,95%CI:0.891-0.999,P=0.045].Conclusion SDNNindex is an influencing factor of cognitive dysfunction in patients with cerebral small vessel disease.

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更新日期/Last Update: 1900-01-01