[1]付彩雯,吴 艳.FGF23/Klotho在2型糖尿病肾病和骨质疏松共病中的研究现状[J].医学信息,2024,37(03):176-179.[doi:10.3969/j.issn.1006-1959.2024.03.037]
 FU Cai-wen,WU Yan.Research Status of FGF23/Klotho in the co-morbidities of Type 2 Diabetic Nephropathy and Osteoporosis[J].Journal of Medical Information,2024,37(03):176-179.[doi:10.3969/j.issn.1006-1959.2024.03.037]
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FGF23/Klotho在2型糖尿病肾病和骨质疏松共病中的研究现状()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年03期
页码:
176-179
栏目:
综述
出版日期:
2024-02-01

文章信息/Info

Title:
Research Status of FGF23/Klotho in the co-morbidities of Type 2 Diabetic Nephropathy and Osteoporosis
文章编号:
1006-1959(2024)03-0176-04
作者:
付彩雯吴 艳
(遂宁市中心医院内分泌代谢病科,四川 遂宁 629000)
Author(s):
FU Cai-wenWU Yan
(Department of Endocrinology and Metabolic Diseases,Suining Central Hospital,Suining 629000,Heilongjiang,China)
关键词:
FGF23Klotho2型糖尿病肾病骨质疏松
Keywords:
FGF23KlothoType 2 diabetic nephropathyOsteoporosis
分类号:
R587.2;R681
DOI:
10.3969/j.issn.1006-1959.2024.03.037
文献标志码:
A
摘要:
2型糖尿病和骨质疏松是主要的两个代谢性疾病,随着年龄的增长其发病率均呈逐渐增加的趋势。而糖尿病肾病是糖尿病最主要的微血管并发症之一,糖尿病肾病和骨质疏松的发生发展均与钙磷代谢密切相关。近年来,出现许多关于2型糖尿病肾病和骨质疏松共同发病机制的研究报道,成纤维细胞生长因子23(FGF23)/Klotho轴是热点之一,本文将对其在2型糖尿病肾病和骨质疏松中的作用进行阐述,以期为糖尿病肾病患者早期预防或干预治疗骨质疏松提供一个新的靶点。
Abstract:
Type 2 diabetes mellitus (T2DM) and osteoporosis are two major metabolic diseases. The incidence of both diseases increases with age. However, diabetic nephropathy is one of the major microvascular complications of diabetes, and the development of diabetic nephropathy and osteoporosis is closely related to calcium and phosphorus metabolism. In recent years, there have been many reports on the co-pathogenesis of diabetic nephropathy and osteoporosis. The fibroblast growth factor 23(FGF23)/Klotho axis is one of the hot spots, its role in type 2 diabetic nephropathy and osteoporosis will be discussed in this article in order to provide a new target for early prevention or intervention of osteoporosis in diabetic nephropathy patients.

参考文献/References:

[1]Lee J,Vasikaran S.Current recommendations for laboratory testing and use of bone turnover markers in management of osteoporosis[J].Ann Lab Med,2012,32(2):105-112.[2]Montalcini T,Gallotti P,Coppola A,et al.Association between low C-peptide and low lumbar bone mineral density in postmenopausal women without diabetes[J].Osteoporos Int,2015,26(5):1639-1646.[3]Richter B,Faul C.FGF23 Actions on Target Tissues-With and Without Klotho[J].Front Endocrinol (Lausanne),2018,9:189.[4]Hu MC,Shi M,Zhang J,et al.Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule[J].FASEB J,2010,24(9):3438-3450.[5]Galliera E,Marazzi MG,Gazzaruso C,et al.Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study[J].Immun Ageing,2017,14:13.[6]Silver J,Naveh-Many T.FGF23 and the parathyroid[J].Advances in experimental medicine and biology,2012,728:92-99.[7]Eller-Vainicher C,Cairoli E,Grassi G,et al.Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility[J].J Diabetes Res,2020,2020:7608964.[8]Compston J.Type 2 diabetes mellitus and bone[J].J Intern Med,2018,283(2):140-153.[9]Siddappa R,Mulder W,Steeghs I,et al.cAMP/PKA signaling inhibits osteogenic differentiation and bone formation in rodent models[J].Tissue Eng Part A,2009,15(8):2135-2143.[10]周相娟,郑立强,金秀平.106例2型糖尿病患者骨密度变化的临床观察[J].重庆医学,2009,38(21):2717-2718.[11]Wolf M.Forging forward with 10 burning questions on FGF23 in kidney disease[J].J Am Soc Nephrol,2010,21(9):1427-1435.[12]Seiler S,Heine GH,Fliser D.Clinical relevance of FGF-23 in chronic kidney disease[J].Kidney Int Suppl,2009(114):S34-S42.[13]Titan SM,Zatz R,Graciolli FG,et al.FGF-23 as a predictor of renal outcome in diabetic nephropathy[J].Clin J Am Soc Nephrol,2011,6(2):241-247.[14]Galliera E,Marazzi MG,Gazzaruso C,et al.Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study[J].Immun Ageing,2017,14:13.[15]Perico N,Remuzzi G,Benigni A.Aging and the Kidney[J].Current Opinionin Nephrology and Hypertension,2011,20:312.[16]Zanchi C,Locatelli M,Benigni A,et al.Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor[J].PLoS One,2013,8(8):e70775.[17]Kuro-o M.Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism[J].Curr Opin Nephrol Hypertens,2006,15(4):437-441.[18]Nakai K,Komaba H,Fukagawa M.New insights into the role of fibroblast growth factor 23 in chronic kidney disease[J].J Nephrol,2010,23(6):619-625.[19]Inci A,Sari F,Olmaz R,et al.Soluble Klotho levels in diabetic nephropathy: relationship with arterial stiffness[J].Eur Rev Med Pharmacol Sci,2016,20(15):3230-3237.[20]Yamada H,Kuro-O M,Hara K,et al.The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio Is a Useful Marker of Atherosclerosis in Early-Stage Chronic Kidney Disease[J].PLoS One,2016,11(8):e0160782.[21]El-Saeed AM,El-Mohasseb GF.Circulating Fibroblast Growth Factors 21 and 23 as Biomarkers of Progression in Diabetic Nephropathy in Type 2 Diabetes with Normoalbuminuria[J].Egypt J Immunol,2017,24(2):93-99.[22]Chen H,Li J,Zhang D,et al.Role of the fibroblast growth factor 19 in the skeletal system[J].Life Sci,2021,265:118804.[23]Zhang X,Guo K,Xia F,et al.FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation[J].BMC Biotechnol,2018,18(1):33.[24]Wang H,Yoshiko Y,Yamamoto R,et al.Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro[J].J Bone Miner Res,2008,23(6):939-948.[25]Sitara D,Razzaque MS,Hesse M,et al.Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice[J].Matrix Biol,2004,23(7):421-432.[26]Jüppner H.Phosphate and FGF-23[J].Kidney Int,2011,79121:S24-S27.[27]Uhlig K,Berns JS,Kestenbaum B,et al.KDOQI US commentary on the 2009 KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of CKD-Mineral and Bone Disorder (CKD-MBD)[J].Am J Kidney Dis,2010,55(5):773-799.[28]Kanda E,Yoshida M,Sasaki S.Applicability of fibroblast growth factor 23 for evaluation of risk of vertebral fracture and chronic kidney disease-mineral bone disease in elderly chronic kidney disease patients[J].BMC Nephrol,2012,13:122.[29]Khundmiri SJ,Murray RD,Lederer E.PTH and vitamin D[J].Compr Physiol,2016,6(2):561-601.[30]韩冬梅,毛维维,巩伟伟,等.2型糖尿病肾病患者临床分期与骨质疏松及生长因子的关系[J].医学临床研究,2020,37(9):1297-1299.

更新日期/Last Update: 1900-01-01