[1]彭水华,杨智文,廖乙媚,等.哌拉西林钠他唑巴坦钠相关腹泻的临床特征分析[J].医学信息,2024,37(04):61-64.[doi:10.3969/j.issn.1006-1959.2024.04.010]
　PENG Shui-hua,YANG Zhi-wen,LIAO Yi-mei,et al.Analysis of Clinical Characteristics of Diarrhea Caused by Piperacillin/Tazobactam[J].Journal of Medical Information,2024,37(04):61-64.[doi:10.3969/j.issn.1006-1959.2024.04.010]
点击复制

哌拉西林钠他唑巴坦钠相关腹泻的临床特征分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年04期
页码:
61-64
栏目:
公共卫生信息学
出版日期:
2024-02-15

文章信息/Info

Title:
Analysis of Clinical Characteristics of Diarrhea Caused by Piperacillin/Tazobactam
文章编号:
1006-1959（2024）04-0061-04
作者:
彭水华; 杨智文; 廖乙媚; 等
（广西医科大学第八附属医院/贵港市人民医院临床药学室，广西 贵港 537100）
Author(s):
PENG Shui-hua; YANG Zhi-wen; LIAO Yi-mei; et al.
(Department of Clinical Pharmacy,the Eighth Affiliated Hospital of Affiliated Hospital of Guangxi Medical University/Guigang City People’s Hospital,Guigang 537100,Guangxi,China)
关键词:
哌拉西林钠他唑巴坦钠; 腹泻; 水样便; 抗菌药物相关性腹泻
Keywords:
Piperacillin/tazobactam; Diarrhea; Watery stool; Antibiotic-associated diarrhea
分类号:
R595.3
DOI:
10.3969/j.issn.1006-1959.2024.04.010
文献标志码:
A
摘要:
目的 总结哌拉西林钠他唑巴坦钠引起腹泻的临床特征，为临床用药时快速、准确判断药品不良反应，保证安全、有效用药提供参考依据。方法 收集2014年1月-2022年12月贵港市人民医院收治的哌拉西林钠他唑巴坦钠致腹泻的26例病例，对性别、年龄分布、临床表现、用药时间、累积剂量、实验室检查结果、临床处理方法及转归等信息进行统计分析。结果 腹泻以大便次数增多、水样便为主，主要发生在距离用药后的2 d内，用药剂量小于36 g时，及时停药，对症治疗后，腹泻好转。结论 在使用注射用哌拉西林钠他唑巴坦钠后，出现相关性腹泻时，及时完善相关检查，评估病情，及时停药或更改治疗方案。
Abstract:
Objective To summarize the clinical characteristics of diarrhea caused by piperacillin/tazobactam, and to provide reference for rapid and accurate judgment of adverse drug reactions in clinical medication, so as to ensure safe and effective medication.Methods A total of 26 cases of diarrhea caused by piperacillin/tazobactam admitted to Guigang City People’s Hospital from January 2014 to December 2022 were collected. The gender, age distribution, clinical manifestations, medication time, cumulative dose, laboratory examination results, clinical treatment methods and outcomes were statistically analyzed.Results After medication (<36 g or less), most patients showed stool frequency increased and watery stools in two days, but improved after they stopped drugs and symptomatic treatment.Conclusion Clinically, perfect inspection to assess patient’s condition, stopping medication timely or adjusting treatment plan are helpful to improve with piperacillin/tazobactam related diarrhea.

参考文献/References:

[1]陈虹,范铁艳,邱爽,等.实体器官移植术后腹泻的深度解析[J].实用器官移植电子杂志,2021,9(1):56.[2]Workie GY,Akalu TY,Baraki AG.Environmental factors affecting childhood diarrheal disease among under-five children in Jamma district, South Wello zone, Northeast Ethiopia[J].BMC Infect Dis,2019,19(1):804.[3]Chen Y,Xiang Q,Liu L.Comparison of antibiotic-associated diarrhea caused by cefoperazone/sulbactam or piperacillin/tazobactam in neurosurgery patients[J].J Int Med Res,2021,49(5):3000605211019661.[4]中华人民共和国卫生部.医院感染诊断标准(试行)[J].中华医学杂志,2001,81(5):314-320.[5]郑跃杰,武庆斌,方峰,等.儿童抗生素相关性腹泻诊断、治疗和预防专家共识[J].中华实用儿科临床杂志,2021,36(6):424-430.[6]Marina F,Ellen EB,John P,et al.Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health[J].Gut,2021,70(3):595-605.[7]汪复,张婴元.实用抗感染治疗学:抗感染治疗学(第三版)[M].北京:人民卫生出版社,2020.[8]张义春,何宇飞.一例哌拉西林钠他唑巴坦钠引起腹泻的病例分析[J].山东化工,2020,49(3):94,96.[9]Ma H,Zhang L,Zhang Y,et al.Combined administration of antibiotics increases the incidence of antibiotic-associated diarrhea in critically ill patients[J].Infect Drug Resist,2019,12:1047-1054.[10]郑晓青,祝焕杰,赵骏,等.呼吸内科住院患者抗生素相关性腹泻的临床特征及危险因素分析[J].浙江医学,2020,42(18):1981-1983,1987.[11]王睿菁,郑冰心,曲连悦.加强监护病房患者抗菌药物相关性腹泻临床分析[J].中国医院用药评价与分析,2020,20(10):1273-1275,1280.[12]冯钰,郑彬茹,张葆青.小儿难辨梭菌腹泻中医治疗病例报道[J].中国中西医结合儿科学,2016,8(3):369-370.[13]徐元平,杨辉,魏继红,等.重症肺炎临床特点及其并发抗生素相关性腹泻的临床分析[J].中华肺部疾病杂志(电子版),2021,14(4):472-474.[14]郭利涛,孙婧婧,张蕾,等.重症患者抗菌药物相关性腹泻影响因素分析[J].中华医院感染学杂志,2019,29(5):661-664.[15]金淑芳.抗生素相关性腹泻的发病机制及诊治原则[J].医学理论与实践,2013(23):3112-3115.[16]陆冬慧,万燕明,蔺小培.细菌性重症肺炎患儿继发抗生素相关性腹泻预测模型的构建和验证[J].安徽医学,2022,43(11):1289-1293.[17]王娟娟,卢险峰.呼吸系统危重症老年患者抗生素相关性腹泻临床观察[J].中外医学研究,2022,20(24):171-175.[18]徐英春,张曼.中国成人艰难梭菌感染诊断和治疗专家共识[J].协和医学杂志,2017,8(2):131-138.[19]秦金花.艰难梭菌感染危险因素与临床特征分析[D].呼和浩特:内蒙古医科大学,2019.[20]陈思敏,毛杰,陈志茹.益生菌联合水溶性膳食纤维对老年抗生素相关性腹泻的防治效果[J].天津医药,2018,46(3):284-287.[21]杜春艳,王春晖.不同益生菌对新生儿抗生素相关性腹泻肠道菌群平衡的影响[J].实用临床医药杂志,2020,24(19):34-36,40.

相似文献/References:

[1]黄绮筠,陈桂铃,汤耀光,等.儿童沙门菌肠炎临床用药疗效比较分析[J].医学信息,2018,31(01):127.[doi:10.3969/j.issn.1006-1959.2018.01.049]
　HUANG Qi-yun,CHEN Gui-ling,TANG Yao-guang,et al.Comparative Analysis of Clinical Efficacy of Salmonella Enteritis in Children[J].Journal of Medical Information,2018,31(04):127.[doi:10.3969/j.issn.1006-1959.2018.01.049]
[2]梁丽俊,刘原杰,张绿浪.艾灸神阙穴治疗艾滋病脾虚型腹泻理论基础[J].医学信息,2018,31(12):143.[doi:10.3969/j.issn.1006-1959.2018.12.045]
[3]王俊全,祝清国.肾移植术后感染性腹泻的诊疗分析[J].医学信息,2019,32(02):51.[doi:10.3969/j.issn.1006-1959.2019.02.017]
　WANG Jun-quan,ZHU Qing-guo.Diagnosis and Treatment of Infectious Diarrhea after Renal Transplantation[J].Journal of Medical Information,2019,32(04):51.[doi:10.3969/j.issn.1006-1959.2019.02.017]
[4]王 菡,刘小红.急性腹泻患儿临床特征及轮状病毒感染情况分析[J].医学信息,2020,33(03):133.[doi:10.3969/j.issn.1006-1959.2020.03.041]
　WANG Han,LIU Xiao-hong.Analysis of Clinical Features and Detection of Rotavirus in Children with Acute Diarrhea[J].Journal of Medical Information,2020,33(04):133.[doi:10.3969/j.issn.1006-1959.2020.03.041]
[5]冯宏达,高 翔.双歧三联活菌片联合蒙脱石散治疗小儿腹泻的疗效[J].医学信息,2020,33(15):144.[doi:10.3969/j.issn.1006-1959.2020.15.045]
　FENG Hong-da,GAO Xiang.Clinical Effect of Bifid Triple Viable Bacteria Tablets Combined with MontmorillonitePowder in the Treatment of Infantile Diarrhea[J].Journal of Medical Information,2020,33(04):144.[doi:10.3969/j.issn.1006-1959.2020.15.045]
[6]王 可.复合凝乳酶胶囊治疗小儿消化不良性腹泻的效果观察[J].医学信息,2020,33(16):159.[doi:10.3969/j.issn.1006-1959.2020.16.051]
　WANG Ke.Observation on the Effect of Compound Rennet Capsules in the Treatment of Dyspeptic Diarrhea in Children[J].Journal of Medical Information,2020,33(04):159.[doi:10.3969/j.issn.1006-1959.2020.16.051]
[7]陈孝辉.哌拉西林钠他唑巴坦钠联合氨溴索治疗慢性阻塞性肺疾病的临床效果[J].医学信息,2022,35(13):97.[doi:10.3969/j.issn.1006-1959.2022.13.021]
　CHEN Xiao-hui.Clinical Effect of Piperacillin Sodium and Tazobactam Sodium Combined with Ambroxol in the Treatment of Chronic Obstructive Pulmonary Disease[J].Journal of Medical Information,2022,35(04):97.[doi:10.3969/j.issn.1006-1959.2022.13.021]
[8]曾文宏,叶芳芳,周志明.哌拉西林钠他唑巴坦钠联合左氧氟沙星治疗慢性支气管炎的临床疗效及安全性观察[J].医学信息,2022,35(23):140.[doi:10.3969/j.issn.1006-1959.2022.23.029]
　ZENG Wen-hong,YE Fang-fang,ZHOU Zhi-ming.Observation on Clinical Efficacy and Safety of Piperacillin Sodium and Tazobactam Sodium Combined with Levofloxacin in the Treatment of Chronic Bronchitis[J].Journal of Medical Information,2022,35(04):140.[doi:10.3969/j.issn.1006-1959.2022.23.029]
[9]叶芳芳,周志明,曾文宏.哌拉西林钠他唑巴坦钠联合左氧氟沙星对支气管扩张患者气道功能、炎症反应的影响[J].医学信息,2023,36(01):103.[doi:10.3969/j.issn.1006-1959.2023.01.020]
　YE Fang-fang,ZHOU Zhi-ming,ZENG Wen-hong.Effect of Piperacillin Sodium and Tazobactam Sodium Combined with Levofloxacin on Airway Function and Inflammatory Response in Patients with Bronchiectasis[J].Journal of Medical Information,2023,36(04):103.[doi:10.3969/j.issn.1006-1959.2023.01.020]

更新日期/Last Update: 1900-01-01