[1]古丽娜尔·阿不都拉.幽门螺旋杆菌与胃食管反流病的相关性研究[J].医学信息,2024,37(13):90-93.[doi:10.3969/j.issn.1006-1959.2024.13.017]
　Study on the Correlation Between Helicobacter Pylori and Gastroesophageal Reflux Disease.Study on the Correlation Between Helicobacter Pylori and Gastroesophageal Reflux Disease[J].Journal of Medical Information,2024,37(13):90-93.[doi:10.3969/j.issn.1006-1959.2024.13.017]
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幽门螺旋杆菌与胃食管反流病的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年13期
页码:
90-93
栏目:
论著
出版日期:
2024-07-01

文章信息/Info

Title:
Study on the Correlation Between Helicobacter Pylori and Gastroesophageal Reflux Disease
文章编号:
1006-1959（2024）13-0090-04
作者:
古丽娜尔·阿不都拉
（喀什地区第一人民医院健康管理中心，新疆 喀什 844000）
Author(s):
Study on the Correlation Between Helicobacter Pylori and Gastroesophageal Reflux Disease
(Health Management Center of the First People’s Hospital of Kashgar,Kashgar 844000,Xinjiang,China)
关键词:
幽门螺旋杆菌; 胃食管反流病; 咽喉炎
Keywords:
elicobacter pylori; Gastroesophageal reflux disease; Pharyngolaryngitis
分类号:
R573.9
DOI:
10.3969/j.issn.1006-1959.2024.13.017
文献标志码:
A
摘要:
目的 研究幽门螺旋杆菌（Hp）与胃食管反流病的相关性。方法 选取2022年1月-2023年1月在我院诊治的63例胃食管反流病患者为研究对象，进行Hp检测，观察胃食管反流病患者Hp阳性率、不同分级胃食管反流患者Hp感染程度，单分析胃食管反流病患者Hp感染的影响因素。结果 63例胃食管反流患者Hp阳性率为63.49%；A级、B级患者Hp感染++、Hp+++、Hp++++占比均低于C级、D级患者，Hp感染+占比高于C级、D级患者（P＜0.05）；不同年龄、性别、病程、合并吸烟、合并喝酒的胃食管反流病患者Hp感染率比较，差异无统计学意义（P＞0.05），合并咽喉炎、合并消化道症状的胃食管反流病患者Hp感染率比较，差异有统计学意义（P＜0.05）；多因素 Logistic 回归分析显示，咽喉炎、消化道症状、胃食管反流分级是胃食管反流病患者Hp感染的危险因素（P＜0.05）。结论 胃食管反流病患者Hp感染率相对较高，且胃食管反流越严重的患者Hp感染程度越严重，Hp可能在胃食管反流病中起保护作用。同时胃食管反流患者Hp感染与合并咽喉炎、消化道症状存、胃食管反流分级存在一定的相关性，在治疗胃食管反流病时应加强高危患者Hp的检测，以为临床治疗提供准确的参考依据。
Abstract:
Objective To study the correlation between Helicobacter pylori (Hp) and gastroesophageal reflux disease.Methods A total of 63 patients with gastroesophageal reflux disease diagnosed and treated in our hospital from January 2022 to January 2023 were selected as the research objects. Hp was detected. The positive rate of Hp in patients with gastroesophageal reflux disease and the degree of Hp infection in patients with different grades of gastroesophageal reflux were observed. The influencing factors of Hp infection in patients with gastroesophageal reflux disease were analyzed.Results The positive rate of Hp in 63 patients with gastroesophageal reflux was 63.49%. The proportion of Hp infection++, Hp+++ and Hp++++ in patients with grade A and grade B was lower than that in patients with grade C and grade D, and the proportion of Hp infection+ was higher than that in patients with grade C and grade D (P<0.05). There was significant difference in Hp infection rate between patients with gastroesophageal reflux disease complicated with laryngitis and gastrointestinal symptoms (P<0.05). Multivariate logistic regression analysis showed that pharyngitis, gastrointestinal symptoms, and gastroesophageal reflux grade were risk factors for Hp infection in patients with gastroesophageal reflux disease (P<0.05).Conclusion The infection rate of Hp in patients with gastroesophageal reflux disease is relatively high, and the more serious the gastroesophageal reflux is, the more serious the Hp infection is. Hp may play a protective role in gastroesophageal reflux disease. At the same time, there is a certain correlation between Hp infection in patients with gastroesophageal reflux and laryngitis, gastrointestinal symptoms and gastroesophageal reflux grading. In the treatment of gastroesophageal reflux disease, the detection of Hp in high-risk patients should be strengthened to provide accurate reference for clinical treatment.

参考文献/References:

[1]张雪莲,王一平,吴维宇,等.四联疗法联合口腔洁治除消化性溃疡合并幽门螺杆菌感染的疗效研究[J].成都医学院学报,2017,12(5):576-578.[2]张帆,姚利,郑世信.咽喉反流与嗓音疾病相关性初步评估[J].重庆医学,2017,18(A01):32-35.[3]李进让,肖水芳,李湘平,等.咽喉反流性疾病诊断与治疗专家共识(2017年)解读[J].中华耳鼻咽喉头颈外科杂志,2017,51(5):327-332.[4]罗舒丹.幽门螺旋杆菌及其相关性胃病与结直肠腺瘤的相关性研究[D].兰州:甘肃中医药大学,2020.[5]包小敏,杨欢,石姚,等.幽门螺旋杆菌感染与喉病损的相关性分析[J].临床耳鼻咽喉头颈外科杂志,2020,30(9):221-224.[6]耿春雨.幽门螺旋杆菌毒力基因表达多态性与胃疾病的关联性研究[D].兰州:兰州大学,2018.[7]张伟,徐斌,鲁明.血脂异常、胃泌素-17、幽门螺旋杆菌在不同病理类型胃息肉中的表达及关联性[J].分子诊断与治疗杂志,2023,18(2):131-135.[8]张振山,姚天宇,许迪.幽门螺旋杆菌抗体、胃蛋白酶原、促胃液素-17与胃癌临床分期的相关性[J].医学研究与教育,2022,25(12):280-283.[9]蔡亮.分析幽门螺旋杆菌相关性胃溃疡的药物治疗方案及疗效[J].黑龙江医药,2022,25(12):456-460.[10]廖晓意,陈昫,唐舒,等.幽门螺旋杆菌相关胃病脾胃湿热证及脾气虚证NLRP3/IL-1β的表达差异性研究[J].广州中医药大学学报,2022,16(12):274-276.[11]王清华,高艳灵.超声和24小时食管动态pH监测对新生儿胃食管反流诊断价值分析[J].交通医学,2023,20(4):13-15.[12]徐宏薇,徐锦江.动态24h食管pH监测对胃食管反流患者生活质量的影响[J].锦州医科大学学报,2022,15(8):123-125.[13]王玲,罗伟,张雪莲.胃食管反流性咽喉疾病与幽门螺旋杆菌感染相关性研究[J].北华大学学报,2018,11(2):316-320.[14]魏贝,王倩倩,李春苗.小儿胃食管反流性咳嗽程度与胃食管反流的关系研究[J].内蒙古医学杂志,2020,31(8):145-150.[15]阿里木·买买提,陶发明,祖里培亚·艾拜都拉,等.胃食管反流相关性慢性咳嗽并咽喉反流患者的反流特征[J].中华胃食管反流病电子杂志,2020,15(8):158-160.[16]唐素萍,刘艳琳,高虹,等.胃食管反流性咳嗽症状严重度与胃食管反流程度的相关性[J].中华儿科杂志,2018,56(7):534-538.[17]殷润开,赵瑞芹,白革兰,等.小儿胃食管反流病相关危险因素的分析[J].中国医师杂志,2019,21(6):898-900.[18]李远鹏,李天林,陈亮.24h食管pH检测对慢性咳嗽诊治的临床价值[J].临床肺科杂志,2019,24(9):1705-1706.[19]吴李仲,林全纲,吴祥基.反流性咽喉炎合并幽门螺杆菌感染的临床诊治研究[J].山西医药杂志,2018,45(9):1064-1066.[20]吴甲龙.十二指肠胃反流、胃食管反流、咽喉反流的一致性研究[D].洛阳:河南科技大学,2022.

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更新日期/Last Update: 1900-01-01