[1]吴晓玲,周桂华.miR-187在宫颈癌中的表达与临床病理关系的研究[J].医学信息,2018,31(16):69-71.[doi:10.3969/j.issn.1006-1959.2018.16.019]
　WU Xiao-ling,ZHOU Gui-hua.Expression of miR-187 in Cervical Cancer and Its Relationship with Clinicopathological Features[J].Journal of Medical Information,2018,31(16):69-71.[doi:10.3969/j.issn.1006-1959.2018.16.019]
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miR-187在宫颈癌中的表达与临床病理关系的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年16期
页码:
69-71
栏目:
论著
出版日期:
2018-08-15

文章信息/Info

Title:
Expression of miR-187 in Cervical Cancer and Its Relationship with Clinicopathological Features
文章编号:
1006-1959（2018）16-0069-03
作者:
吴晓玲; 周桂华
湖南省妇幼保健院检验科，湖南 长沙 410008
Author(s):
WU Xiao-ling; ZHOU Gui-hua
Department of Laboratory Medicine,Hunan Maternal and Child Health Care Hospital,Changsha 410008,Hunan,China
关键词:
miR-187; 宫颈癌; 实时荧光定量PCR
Keywords:
Key words：miR-187; Cervical cancer; Real-time fluorescent quantitative PCR
分类号:
R365
DOI:
10.3969/j.issn.1006-1959.2018.16.019
文献标志码:
A
摘要:
目的 探讨miR-187在宫颈癌中的表达及与临床病理特征的关系。方法 收集78例宫颈癌组织标本，同时收取同期手术的60例正常宫颈组织标本，采用实时荧光定量PCR检测方法检测两种组织中miR-187的表达量并进行比较，同时分析癌组织中miR-187的表达水平与临床病理特征的关系。结果 宫颈癌组织中miR-187的表达量低于正常宫颈组织标本，统计学意义显著（P＜0.001）；宫颈癌组织中miR-187的表达水平与宫颈癌组织的分化程度、患者的临床分期及有无淋巴结转移情况有关（P＜0.05），而与患者的年龄、肿块类型、肿瘤大小及组织学类型无关（P＞0.05）。结论 miR-187在宫颈癌组织中低表达，可能作为其诊断与治疗的重要靶点。
Abstract:
Abstract：Objective To investigate the expression of miR-187 in cervical cancer and its relationship with clinicopathological features.Methods 78 cases of cervical cancer tissues were collected,60 normal cervical tissue specimens were collected at the same time from simultaneous operation.The expression of miR-187 in two kinds of tissues was detected and compared by real-time fluorescence quantitative PCR,and the relationship between the expression of miR-187 and clinicopathological features was analyzed. Results The expression of miR-187 in cervical cancer was significantly lower than that in normal cervical tissue,with statistical significance(P<0.001).The expression of miR-187 in cervical cancer was related to the degree of differentiation,clinical stage and lymph node metastasis (P<0.05),but not to age,tumor type,tumor size and histological type(P>0.05).Conclusion Low expression of miR-187 may be an important target for diagnosis and treatment of cervical cancer.

参考文献/References:

[1]Wentzensen N,Schiffman M.Accelerating cervical cancer control and prevention[J].Lancet Public Health,2018(3):e6-e7.
[2]Li Y,Xu C.Human Papillomavirus-Related Cancers[J].Adv Exp Med Biol,2017(1018):23-34.
[3]Van Ostade X,Dom M,Tjalma W,et al.Candidate biomarkers in the cervical vaginal fluid for the(self-)diagnosis of cervical precancer[J].Arch Gynecol Obstet,2018,297(2):295-311.
[4]Satapathy S,Batra J,Jeet V,et al.MicroRNAs in HPV associated cancers:small players with big consequences[J].Expert Rev Mol Diagn,2017,17(7):711-722.
[5]Bertoli G,Cava C,Castiglioni I.MicroRNAs:New Biomarkers for Diagnosis,Prognosis,Therapy Prediction and Therapeutic Tools for Breast Cancer[J].Theranostics,2015,5(10):1122-1143.
[6]Huang QB,Ma X,Zhang X,et al.Down-Regulated miR-30a in Clear Cell Renal Cell Carcinoma Correlated with Tumor Hematogenous Metastasis by Targeting Angiogenesis-Specific DLL4[J].PLoS One,2013,8(6):e67294.
[7]Ma X,Shen D,Li H,et al.MicroRNA-185 inhibits cell proliferation and induces cell apoptosis by targeting VEGFA directly in von Hippel-Lindau-inactivated clear cell renal cell carcinoma[J].Urol Oncol,2015,33(4):161-169.
[8]Zhao S,Yao D,Chen J,et al.Circulating miRNA-20a and miRNA-203 for screening lymph node metastasis in early stage cervical cancer[J].Genet Test Mol Biomarkers,2013,17(8):631-636.
[9]Fei D,Zhao K,Yuan H,et al.MicroRNA-187 exerts tumor-suppressing functions in osteosarcoma by targeting ZEB2[J].Am J Cancer Res,2016,6(12):2859-2868.
[10]Wang ZS,Zhong M,Bian YH,et al.MicroRNA-187 inhibits tumor growth and invasion by directly targeting CD276 in colorectal cancer[J].Oncotarget,2016,7(28):44266-44276.
[11]Han X,Wang X,Zhao B,et al.MicroRNA-187 inhibits tumor growth and metastasis via targeting of IGF-1R in hepatocellular carcinoma[J].Mol Med Rep,2017,16(2):2241-2246.
[12]Huang F,Jin Y,Wei Y.MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6[J].Oncol Lett,2016,11(4):2845-2850.
[13]Casanova-Salas I,Masia E,Arminan A,et al.MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer[J].PLoS One,2015,10(5):e125576.
[14]Cui C,Shi X.miR-187 inhibits tumor growth and invasion by directly targeting MAPK12 in osteosarcoma[J].Exp Ther Med,2017,14(2):1045-1050.
[15]Gupta S,Kumar P,Das BC.HPV:Molecular pathways and targets[J].Curr Probl Cancer,2018,42(2):161-174.
[16]Hoppe-Seyler K,Bossler F,Braun JA,et al.The HPV E6/E7 Oncogenes:Key Factors for Viral Carcinogenesis and Therapeutic Targets[J].Trends Microbiol,2018,26(2):158-168.
[17]Oh DY,Kim S,Choi YL,et al.HER2 as a novel therapeutic target for cervical cancer[J].Oncotarget,2015,6(34):36219-36230.

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更新日期/Last Update: 2018-08-15