[1]顾万娟,李 亮,张 振,等.多重耐药菌的临床分布与耐药性分析[J].医学信息,2019,32(15):116-118,122.[doi:10.3969/j.issn.1006-1959.2019.15.038]
　GU Wan-juan,LI Liang,ZHANG Zhen,et al.Analysis of Clinical Distribution and Drug Resistance of Multi-drug Resistant Bacteria[J].Journal of Medical Information,2019,32(15):116-118,122.[doi:10.3969/j.issn.1006-1959.2019.15.038]
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多重耐药菌的临床分布与耐药性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年15期
页码:
116-118,122
栏目:
调查分析
出版日期:
2019-08-01

文章信息/Info

Title:
Analysis of Clinical Distribution and Drug Resistance of Multi-drug Resistant Bacteria
文章编号:
1006-1959（2019）15-0116-04
作者:
顾万娟; 李 亮; 张 振; 杜希林
江苏省淮安市淮阴医院检验科，江苏 淮安 223300
Author(s):
GU Wan-juan; LI Liang; ZHANG Zhen; DU Xi-lin
Department of Clinical Laboratory,Huaiyin Hospital,Huai'an 223300,Jiangsu,China
关键词:
多重耐药菌; 耐药率; 抗菌药物; 医院感染
Keywords:
Key words：Multi-drug resistant bacteria; Drug resistance rate; Antibacterial drugs; Nosocomial infections
分类号:
R446.5
DOI:
10.3969/j.issn.1006-1959.2019.15.038
文献标志码:
A
摘要:
目的 分析淮阴医院2017年多重耐药菌（MDROS）的分布特点以及耐药情况，为临床抗生素合理使用提供有效的实验数据。方法 回顾性分析我院2017年1月~12月261株MDROS的检出情况，分析常见抗菌药物的耐药率。结果 2017年我院共分离出1822株阳性菌株，其中MDROS 261株，占总菌株数的14.32%。分别为产超光谱β-内酰胺酶（EsBLs）大肠埃希151株（57.85%）、耐甲氧西林金黄色葡萄球菌（MRSA）为33 株（12.64%）、产 EsBLs肺炎克雷伯菌27株（10.34%）、耐碳氢霉烯类鲍曼不动杆菌（MDR-AB）24株（9.20%）、多重耐药铜绿假单胞菌（MDR-PA）14株（5.36%）、产EsBLs奇异变形杆菌8株（3.07）%、耐万古霉素肠球菌（VRE）4株（1.53%）。MDROS的标本主要来自于痰液、脓、分泌物及中段尿等。MDROS中革兰氏阴性杆菌中耐药率较高的是头孢类、喹诺酮类药物；革兰氏阳性菌中耐药率较高的是青霉素类、大环类酯类药物。结论 医院需加强抗菌药物的管理，重视MDROS的监测，临床医生应根据药敏结果合理使用抗菌药物，有效预防、控制MDROS的感染和传播。
Abstract:
Abstract：Objective To analyze the distribution characteristics and drug resistance of multidrug-resistant bacteria (MDROS) in Huaiyin Hospital in 2017, and provide effective experimental data for the rational use of clinical antibiotics. Methods A retrospective analysis of the detection of 261 MDROS in our hospital from January to December 2017 was conducted to analyze the resistance rate of common antibiotics.Results In 2017, a total of 1822 positive strains were isolated from our hospital, of which 261 were MDROS, accounting for 14.32% of the total number of strains. There were 151 strains (57.85%) of Escherichia coli β-lactamase (EsBLs), 33 strains (12.64%) of methicillin-resistant Staphylococcus aureus (MRSA), 27 strains (10.34%) of Escherichia coli Klebsiella pneumoniae, 24 strains (9.20%) of carbenol-resistant Acinetobacter baumannii (MDR-AB), multidrug-resistant Pseudomonas aeruginosa (MDR-PA) 14 strains (5.36%), 8 strains (3.07)% of Escherichia coli, and 4 strains of vancomycin-resistant enterococci (VRE) (1.53%). MDROS specimens are mainly derived from sputum, pus, secretions and mid-stage urine. The high resistance rate of Gram-negative bacilli in MDROS is cephalosporins and quinolones; the higher resistance rate among Gram-positive bacteria is penicillins and macrocyclic esters.Conclusion The hospital needs to strengthen the management of antibacterial drugs and pay attention to the monitoring of MDROS. Clinicians should rationally use antibiotics according to the results of drug susceptibility to effectively prevent and control the infection and transmission of MDROS.

参考文献/References:

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更新日期/Last Update: 2019-08-01