[1]张 露,刘 铭,彭玉龙,等.盐酸羟考酮缓释片对急性放射性黏膜炎所致疼痛的应用效果评价[J].医学信息,2019,32(08):148-150.[doi:10.3969/j.issn.1006-1959.2019.08.045]
　ZHANG Lu,LIU Ming,PENG Yu-long,et al.Evaluation of the Effect of Oxycodone Hydrochloride Sustained-release Tablets on Pain Caused by Acute Radiation Mucositis[J].Journal of Medical Information,2019,32(08):148-150.[doi:10.3969/j.issn.1006-1959.2019.08.045]
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盐酸羟考酮缓释片对急性放射性黏膜炎所致疼痛的应用效果评价()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年08期
页码:
148-150
栏目:
药物与临床
出版日期:
2019-04-15

文章信息/Info

Title:
Evaluation of the Effect of Oxycodone Hydrochloride Sustained-release Tablets on Pain Caused by Acute Radiation Mucositis
文章编号:
1006-1959（2019）08-0148-03
作者:
张 露1; 刘 铭2; 彭玉龙1; 陈荣辉1; 杨 平3; 盘爱兵3; 邓惠君1
（东莞东华医院肿瘤内科1，外科2，放疗科3，广东 东莞 523110）
Author(s):
ZHANG Lu1; LIU Ming2; PENG Yu-long1; CHEN Rong-hui1; YANG Ping3; PAN Ai-bing3; DENG Hui-jun1
(Department of Oncology1,Department of Surgery2,Department of Radiotherapy3,Dongguan Donghua Hospital,Dongguan 523110,Guangdong,China)
关键词:
盐酸羟考酮缓释片; 急性放射性黏膜炎; 癌痛
Keywords:
Oxycodone hydrochloride sustained-release tablets; Acute radioactive mucositis;  Cancer pain
分类号:
R971+.2
DOI:
10.3969/j.issn.1006-1959.2019.08.045
文献标志码:
A
摘要:
目的 探讨应用盐酸羟考酮缓释片处理急性放射性黏膜炎所致疼痛的效果。方法 选择2014年12月~2018年9月我院肿瘤内科收治106例鼻咽癌放化疗患者，随机分为对照组和实验组，每组53例；对照组常规行口腔护理、雾化治疗、非甾体类止痛药物治疗、抗炎治疗及营养支持治疗，实验组在对照组基础上应用盐酸羟考酮缓释片替代非甾体类止痛药物，比较两组患者在放疗期间及结束时止痛效果、睡眠状态、体重变化、口腔黏膜损伤恢复情况及治疗过程中药物不良反应发生情况。结果 实验组镇痛总有效率为88.68%，高于对照组的15.09%，差异有统计学意义（P＜0.05）；实验组治疗前后体重变化低于对照组，差异有统计学意义（P＜0.05）。实验组中应用羟考酮缓释片期间15.09%的患者出现便秘，5.66%的患者有轻度的恶心头晕，副反应小可耐受。结论 应用小剂量盐酸羟考酮缓释片对减轻急性放射性黏膜炎所致疼痛效果显著，药物不良反应小，无成瘾性，改善患者生活质量及治疗依从性，影响预后。
Abstract:
Objective To investigate the effect of oxycodone hydrochloride sustained-release tablets on pain caused by acute radiation mucositis. Methods From December 2014 to September 2018, 106 patients with radiotherapy and chemotherapy for nasopharyngeal carcinoma were enrolled in our hospital. They were randomly divided into control group and experimental group, with 53 cases in each group. The control group received routine oral care and aerosol therapy. Non-steroidal analgesic drugs, anti-inflammatory treatment and nutritional support treatment. The experimental group used oxycodone hydrochloride sustained-release tablets instead of non-steroidal analgesics on the basis of the control group. The two groups were compared during the radiotherapy period and at the end of the treatment. Effects, sleep status, weight changes, recovery of oral mucosal injury, and adverse drug reactions during treatment. Results The total effective rate of analgesia in the experimental group was 88.68%, which was higher than that in the control group 15.09%, the difference was statistically significant (P<0.05). The weight change of the experimental group before and after treatment was lower than that of the control group, the difference was statistically significant (P< 0.05). In the experimental group, constipation occurred in 15.09% of patients during the administration of oxycodone sustained-release tablets, and 5.66% of patients had mild nausea and dizziness, and the side effects were small tolerable. Conclusion Low-dose oxycodone hydrochloride sustained-release tablets have significant effects on relieving pain caused by acute radiation mucositis. The adverse drug reactions are small, no addiction, improve patients' quality of life and treatment compliance, and affect prognosis.

参考文献/References:

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更新日期/Last Update: 2019-04-15