[1]唐家晨,王 莉,卜笃翰,等.咪达唑仑联合芬太尼辅助机械通气治疗重症肺炎患儿的镇痛效果[J].医学信息,2019,32(09):111-113.[doi:10.3969/j.issn.1006-1959.2019.09.036]
　TANG Jia-chen,WANG Li,BO Du-han,et al.Analgesic Effect of Midazolam Combined with Fentanyl Assisted Mechanical Ventilation in Children with Severe Pneumonia[J].Journal of Medical Information,2019,32(09):111-113.[doi:10.3969/j.issn.1006-1959.2019.09.036]
点击复制

咪达唑仑联合芬太尼辅助机械通气治疗重症肺炎患儿的镇痛效果()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年09期
页码:
111-113
栏目:
临床研究
出版日期:
2019-05-01

文章信息/Info

Title:
Analgesic Effect of Midazolam Combined with Fentanyl Assisted Mechanical Ventilation in Children with Severe Pneumonia
文章编号:
1006-1959（2019）09-0111-03
作者:
唐家晨1; 王 莉2; 卜笃翰1; 郑明秀2; 王桂兰2
（1.江苏省扬州市妇幼保健院儿科，江苏 扬州 225000；2.江苏省苏北人民医院麻醉科，江苏 扬州 225000）
Author(s):
TANG Jia-chen1; WANG Li2; BO Du-han1; ZHENG Ming-xiu2; WANG Gui-lan2
(1.Department of Pediatrics,Yangzhou Maternal and Child Health Hospital,Yangzhou 225000, Jiangsu,China;2.Department of Anesthesiology,Jiangsu Subei People's Hospital,Yangzhou 225000,Jiangsu,China)
关键词:
咪达唑仑; 芬太尼; 机械通气; 重症肺炎
Keywords:
Midazolam; Fentanyl; Mechanical ventilation; Severe pneumonia
分类号:
R726.1
DOI:
10.3969/j.issn.1006-1959.2019.09.036
文献标志码:
A
摘要:
目的 探讨咪达唑仑联合芬太尼辅助治疗机械通气重症肺炎患儿的效果。方法 选择我院2016年7月~2018年7月60例行机械通气治疗的重症肺炎患儿，随机分为观察组与对照组，各30例。对照组单独应用咪达唑仑镇静镇痛，观察组在此基础上联合芬太尼镇静镇痛，比较两组患儿的机械通气时间、住院时间、用药后6、12、24 h的心率、血压、Ramsay 评分及FLACC评分。结果 观察组机械通气时间及住院时间短于对照组，差异有统计学意义（P＜0.05）；用药后6、12、24 h观察组患者心率、血压均低于对照组，差异有统计学意义（P＜0.05）；用药后6、12、24 h观察组Ramsay评分高于对照组， FLACC评分低于对照组，差异均有统计学意义（P＜0.05）。结论 临床上采取咪达唑仑联合芬太尼的，镇静镇痛效果均能明显提升，可稳定血流动力学，缩短患者苏醒时间和住院时间。
Abstract:
Objective To investigate the effect of midazolam combined with fentanyl on mechanical ventilation in children with severe pneumonia. Methods 60 children with severe pneumonia who underwent mechanical ventilation from July 2016 to July 2018 were randomly divided into observation group and control group, 30 cases each. In the control group, midazolam was used for sedation and analgesia. The observation group was combined with fentanyl for sedation and analgesia. The mechanical ventilation time, hospitalization time, heart rate at 6, 12, and 24 h after treatment were compared between the two groups. Blood pressure, Ramsay score and FLACC score. Results The mechanical ventilation time and hospitalization time in the observation group were shorter than those in the control group,the difference was statistically significant (P<0.05). The heart rate and blood pressure of the observation group were lower than those of the control group at 6, 12, and 24 h after treatment,the difference was statistically significant. (P<0.05); the Ramsay score of the observation group was higher than that of the control group at 6, 12, and 24 h after treatment, and the FLACC score was lower than that of the control group, the difference was statistically significant (P<0.05).Conclusion When midazolam combined with fentanyl is used, the sedative and analgesic effects can be significantly improved, which can stabilize hemodynamics and shorten the recovery time and hospitalization time.

参考文献/References:

[1]徐卫华,金丹群,李敏,等.咪达唑仑联合芬太尼在ARDS患儿中的疗效评价[J].医学新知杂志,2014,22(4):276-277.
[2]王俊霞,石磊,赵海涛,等.右美托咪定和咪达唑仑预防短小手术患儿七氟醚复合麻醉恢复期躁动效果的比较[J].中华麻醉学杂志,2014,34(10):1171-1173.
[3]王彦华,王书玲,陈娟,等.舒适评分在先天性心脏病术后机械通气患儿镇静中的应用效果[J].护理实践与研究,2013,10(24):25-26.
[4]中华医学会重症医学分会．重症加强治疗病房病人镇痛和镇静治疗指南(2006)[J].中国实用外科杂志,2006,26(12):893-901．
[5]Celis RE,Birchenall C,Cal MA,et al.Clinical practice guidelines for evidence-based management of sedoanalgesia in critically ill adult patients[J].Med Intensiva,2013,37(8):519-574．
[6]陈雅杏,蓝海燕,梁燕芬.咪达唑仑在新生儿机械通气中镇静镇痛效果评估[J].吉林医学,2015,36(11):2263.
[7]李海英.咪达唑仑联合芬太尼在新生儿呼吸窘迫综合征机械通气治疗中的应用效果分析[J].中国妇幼保健,2018,33(21):4907-4910.

相似文献/References:

[1]郭剑波.酒石酸布托啡诺、氟比洛芬酯、芬太尼联合异丙酚镇痛镇静对ICU内机械通气患者的疗效比较[J].医学信息,2018,31(04):130.[doi:10.3969/j.issn.1006-1959.2018.04.046]
　GUO Jian-Bo.Comparison of Analgesic Effects of Butorphanol Tartrate Flurbiprofen and Fentanyl Combined with Propofol in Patients undergoing Mechanical Ventilation in ICU[J].Journal of Medical Information,2018,31(09):130.[doi:10.3969/j.issn.1006-1959.2018.04.046]
[2]王振山,李艳丽,李晓娟,等.不同浓度罗哌卡因应用于分娩镇痛的临床观察[J].医学信息,2019,32(02):154.[doi:10.3969/j.issn.1006-1959.2019.02.046]
　WANG Zhen-shan,LI Yan-li,LI Xiao-juan,et al.Clinical Observation of Different Concentrations of Ropivacaine for Labor Analgesia[J].Journal of Medical Information,2019,32(09):154.[doi:10.3969/j.issn.1006-1959.2019.02.046]
[3]邱显鹏.右美托咪定及咪达唑仑分别应用于AECOPD伴呼吸衰竭治疗的效果观察[J].医学信息,2018,31(22):145.[doi:10.3969/j.issn.1006-1959.2018.22.042]
　QIU Xian-peng.Efficacy of Dexmetomidine and Midazolam in the Treatment of AECOPD with Respiratory Failure[J].Journal of Medical Information,2018,31(09):145.[doi:10.3969/j.issn.1006-1959.2018.22.042]
[4]涂兆珍,韩学敏,张 帆.右美托咪定辅助用于小儿尿道下裂修补术后镇痛的效果观察[J].医学信息,2018,31(23):139.[doi:10.3969/j.issn.1006-1959.2018.23.040]
　TU Zhao-zhen,HAN Xue-min,ZHANG Fan.Effect of Dexmedetomidine on Postoperative Analgesia in Children with Repair of Hypospadias[J].Journal of Medical Information,2018,31(09):139.[doi:10.3969/j.issn.1006-1959.2018.23.040]
[5]董 鹏.瑞芬太尼复合丙泊酚在腹腔镜手术麻醉中的应用[J].医学信息,2019,32(14):146.[doi:10.3969/j.issn.1006-1959.2019.14.048]
　DONG Peng.Application of Remifentanil Combined with Propofol in Laparoscopic Anesthesia[J].Journal of Medical Information,2019,32(09):146.[doi:10.3969/j.issn.1006-1959.2019.14.048]
[6]郭 端,苏 行,黄 兰.右美托咪定用于机械通气重症患者镇静的 效果及经济评价[J].医学信息,2019,32(13):138.[doi:10.3969/j.issn.1006-1959.2019.13.042]
　GUO Duan,SU Hang,HUANG Lan.Effect and Economic Evaluation of Dexmedetomidine for Sedation in Critically Ill Patients with Mechanical Ventilation[J].Journal of Medical Information,2019,32(09):138.[doi:10.3969/j.issn.1006-1959.2019.13.042]
[7]冯 佩.咪达唑仑静脉给药与传统联合方案治疗小儿惊厥持续状态的安全性[J].医学信息,2020,33(02):140.[doi:10.3969/j.issn.1006-1959.2020.02.041]
　FENG Pei.Safety of Intravenous and Traditional Combination of Midazolam in the Treatment of Repeated Pediatric Convulsions[J].Journal of Medical Information,2020,33(09):140.[doi:10.3969/j.issn.1006-1959.2020.02.041]
[8]张武臣,程金刚,毕延红.利多卡因与芬太尼对急性肾绞痛的镇痛疗效[J].医学信息,2020,33(05):146.[doi:10.3969/j.issn.1006-1959.2020.05.047]
　ZHANG Wu-chen,CHENG Jin-gang,BI Yan-hong.Analgesic Effect of Lidocaine and Fentanyl on Acute Renal Colic[J].Journal of Medical Information,2020,33(09):146.[doi:10.3969/j.issn.1006-1959.2020.05.047]
[9]黄 安,许志文,黄 诚.舒芬太尼复合咪达唑仑在支气管镜检查中的应用价值[J].医学信息,2022,35(21):140.[doi:10.3969/j.issn.1006-1959.2022.21.037]
　HUANG An,XU Zhi-wen,HUANG Cheng.Application Value of Sufentanil Combined with Midazolam in Bronchoscopy[J].Journal of Medical Information,2022,35(09):140.[doi:10.3969/j.issn.1006-1959.2022.21.037]
[10]王永明,王 荣,马 丽.咪达唑仑滴鼻用于新生儿腰椎穿刺镇静的有效性和安全性[J].医学信息,2021,34(06):157.[doi:10.3969/j.issn.1006-1959.2021.06.041]
　WANG Yong-ming,WANG Rong,MA Li.The Effectiveness and Safety of Midazolam Nasal Drops for Lumbar Puncture Sedation in Neonates[J].Journal of Medical Information,2021,34(09):157.[doi:10.3969/j.issn.1006-1959.2021.06.041]

更新日期/Last Update: 2019-05-01